obsolete arthropathy due to hypersensitivity reaction

Arthropathy in Hypersensitivity Reactions

Arthropathy in hypersensitivity reactions refers to a condition where the immune system reacts abnormally to an antigen, leading to joint inflammation and damage. This condition is classified elsewhere in medical literature.

• Causes: Arthropathy in hypersensitivity reactions can occur due to various factors, including allergies, autoimmune diseases, or drug sensitivities.
• Symptoms: The symptoms of arthropathy in hypersensitivity reactions may include:
  • Joint pain and inflammation
  • Swelling and redness around the joints
  • Limited mobility and stiffness in the affected joints
• Types: There are different types of hypersensitivity reactions that can cause arthropathy, including:
  • Type I: Immediate allergic reactions, such as anaphylaxis or urticaria (hives)
  • Type II: Cytotoxic-mediated reactions, where autoantibodies attack self-cells
  • Type III: Immune complex-mediated reactions, where antibodies bind to antigens and cause inflammation
• Treatment: The treatment for arthropathy in hypersensitivity reactions depends on the underlying cause. It may involve medications such as corticosteroids or immunosuppressants to reduce inflammation and suppress the immune system.

References

[10] - This condition is classified elsewhere in medical literature, specifically under ICD-10-CM code M36.4. [14] - A hypersensitivity reaction is an inappropriate or overreactive immune response to an antigen resulting in undesirable effects, which can include arthropathy. [15] - Hypersensitivity reactions such as serum sickness and generalized urticaria can occur with a frequency of <1%, and may be associated with arthropathy.

Based on the provided context, it appears that you are looking for information on the signs and symptoms of an obsolete arthropathy caused by a hypersensitivity reaction.

According to search result [3], Signs and symptoms included arthritis, rash, fever, and lymphadenopathy with an onset 1–5 days after the first or subsequent injections of an infused agent. This suggests that an obsolete arthropathy due to hypersensitivity reaction may present with joint inflammation (arthritis), skin manifestations (rash), elevated body temperature (fever), and swollen lymph nodes (lymphadenopathy).

Additionally, search result [7] mentions clinical signs include a maculopapular rash that often progresses to exfoliative erythroderma, fever, lymphadenopathy, and multivisceral involvement. This indicates that an obsolete arthropathy due to hypersensitivity reaction may also be characterized by a specific type of skin rash (maculopapular rash), which can worsen to involve other parts of the body.

Furthermore, search result [4] lists different symptoms and signs associated with acute infusion reactions, including fevers, rigors, back pain, abdominal pain, nausea, vomiting, diarrhea, and arthritis. While not specifically mentioning obsolete arthropathy, this information suggests that an obsolete arthropathy due to hypersensitivity reaction may share some common symptoms with acute infusion reactions.

It's worth noting that the term "obsolete arthropathy" is not a standard medical term, and it's possible that you meant to ask about a different condition. If you could provide more context or clarify your question, I'd be happy to try and assist you further.

References: [3] by A Sitek · 2023 · Cited by 5 [7] by M Tohyama · 1998 · Cited by 346

Based on the provided context, it appears that there are several diagnostic tests that can be used to diagnose an obsolete arthropathy due to a hypersensitivity reaction.

• Specific IgE testing: This test can help identify specific allergens that may be causing the hypersensitivity reaction. According to search result [4], this test is one of the laboratory tests that can be used to diagnose an RA hypersensitivity reaction.
• Lymphocyte transformation test: This test measures the response of lymphocytes (a type of white blood cell) to various stimuli, including allergens. Search result [4] mentions this test as another laboratory test that can be used to diagnose an RA hypersensitivity reaction.
• Skin patch testing: This test involves applying small amounts of potential allergens to the skin and observing for a reaction. According to search result [15], skin patch testing is one of the diagnostic tests that can be used to diagnose metal hypersensitivity reactions, which may also be relevant in cases of obsolete arthropathy due to hypersensitivity reaction.
• Histological examination: This test involves examining tissue samples under a microscope to look for signs of inflammation or other changes associated with hypersensitivity reactions. Search result [4] mentions histological examination as one of the diagnostic tests that can be used to diagnose an RA hypersensitivity reaction.

It's worth noting that there isn't a single definitive test that can diagnose an obsolete arthropathy due to hypersensitivity reaction, and a combination of these tests may be necessary to make a diagnosis. According to search result [2], there isn't a single test that can diagnose an RA hypersensitivity reaction.

References: [4] - Laboratory tests ([specific] IgE, lymphocyte transformation test), histological examination, dermatological tests (prick tests, epicutaneous testing) [15] - Many of the metals used in orthopaedic surgical implants are immunologically active and can cause hypersensitivity reactions. Most of these metal hypersensitivity (MHS) reactions are type IV/delayed-type hypersensitivity reactions. ... Another challenge is the lack of a definitive diagnostic test. However, skin patch testing and lymphocyte ...

Treatment Options for Obsolete Arthropathy Due to Hypersensitivity Reaction

Obsolete arthropathy, also known as refractory gouty arthropathy, is a condition where the body's immune system reacts to certain medications, leading to severe joint inflammation and pain. In some cases, this reaction can be due to hypersensitivity, making it challenging to treat.

Pegloticase: A Highly Effective but Immunogenic Treatment

According to search result [3], Pegloticase is a highly effective treatment for refractory gouty arthropathy. However, the medication is also highly immunogenic, meaning that it can trigger an immune response in some individuals, leading to hypersensitivity reactions.

Other Treatment Options

While there are no specific treatments mentioned in the search results for obsolete arthropathy due to hypersensitivity reaction, other medications like sulfasalazine and betamethasone suppository have been used to treat related conditions (search result [6]). Additionally, combination therapy with anti-TNF-α and methotrexate has been reported to reduce the development of adverse reactions in rheumatoid arthritis patients (search result [8]).

Importance of Correct Identification

Correct identification of the culprit drug is crucial in preventing further exposure and reducing the risk of hypersensitivity reactions. This can be achieved through a combination of in vitro and/or in vivo tests, as mentioned in search result [12].

Prevalence of Adverse Drug Reactions

It's worth noting that adverse drug reactions are a major cause of morbidity and mortality worldwide (search result [14]). Up to one-third of these reactions are attributable to unpredictable drug hypersensitivity reactions, including those caused by medications like Pegloticase.

References:

• Search result [3]: Pegloticase is a highly effective treatment for refractory gouty arthropathy.
• Search result [6]: Sulfasalazine and betamethasone suppository have been used to treat related conditions.
• Search result [8]: Combination therapy with anti-TNF-α and methotrexate reduces the development of adverse reactions in rheumatoid arthritis patients.
• Search result [12]: Correct identification of the culprit drug is crucial in preventing further exposure and reducing the risk of hypersensitivity reactions.
• Search result [14]: Adverse drug reactions are a major cause of morbidity and mortality worldwide.

Based on the provided context, it appears that you are looking for information on the differential diagnosis of an obsolete arthropathy caused by a hypersensitivity reaction.

According to search result [8], Non-erosive Immune-Mediated Polyarthritis (IMPA) typically results from a type III hypersensitivity reaction. However, this is not directly related to an obsolete arthropathy due to hypersensitivity reaction.

Search result [11] mentions that differential diagnosis of dermal hypersensitivity reaction is broad; clinical correlation is required in all instances. This implies that the differential diagnosis for an obsolete arthropathy caused by a hypersensitivity reaction would also be broad and require clinical correlation.

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