intra-abdominal lymph node mast cell malignancy

Intra-Abdominal Lymph Node Mast Cell Malignancy

Mast cell malignancy involving intra-abdominal lymph nodes is a rare and aggressive form of cancer that affects the mast cells in the abdominal region. This condition is characterized by the uncontrolled growth and spread of malignant mast cells, which can lead to various complications.

Key Features:

• Metastasis: Metastasis occurs first at the local lymph nodes and then potentially spreads to other organs such as the spleen, liver, and bone marrow [7].
• High-grade malignancy: The tumor is composed of high-grade, highly malignant, undifferentiated cells with rapid growth, affecting approximately 90% of cases [10].
• Immune response: The Mast Cell Density (MCD) is increased in well-differentiated cancers, suggesting a mast cell-mediated immune response and possibly contributing to tumor angiogenesis [8].

Synonyms:

• Malignant mast cell tumors involving intra-abdominal lymph nodes
• Mast cell malignancy of intra-abdominal lymph nodes

References:

1. The condition is not associated with human or mouse genes in the MGI database.
2. HN3 (obvious or advanced metastasis) is characterized by altered lymph node architecture, with foci of mast cells organized in a mantle or cord [2].
3. The disease is described as malignant mast cell tumors involving intra-abdominal lymph nodes and Mast cell malignancy of intra-abdominal lymph nodes.
4. DO ID: DOID:13005; Description: None; Synonyms: malignant mast cell tumors involving intra-abdominal lymph nodes, Mast cell malignancy of intra-abdominal lymph nodes [4].
5. The disease is also referred to as Mast cell malignancy of intra-abdominal lymph nodes and Malignant mast cell tumor of intra-abdominal lymph nodes.
6. Disease Ontology Definition: n_a; Synonyms: Mast cell malignancy of intra-abdominal lymph nodes, Mast cell malignancy of intra-abdominal lymph nodes [6].
7. Metastasis occurs first at the local lymph nodes and then potentially to the bone marrow and visceral organs such as the spleen, liver, etc. [7].
8. The MCD is increased in well-differentiated cancers and thought to be a mast cell-mediated immune response and also possibly caused tumor angiogenesis and [8].
9. Preferred Name: Malignant mast cell tumor of intra-abdominal lymph nodes; Synonyms: Malignant mast cell tumour of intra-abdominal lymph nodes [9].
10. High-grade, highly malignant, undifferentiated cells with rapid growth, 90%. Following grading of the tumour, assessment of lymph nodes, an ultrasound of the [10].

Common Signs and Symptoms

Intra-abdominal lymph node mast cell malignancy, also known as malignant mast cell tumors involving intra-abdominal lymph nodes, can exhibit a range of symptoms. These may include:

• Vomiting: This is one of the most common symptoms, often accompanied by nausea (14).
• Loss of appetite: Affected individuals may experience a decrease in hunger or interest in food (1, 14).
• Lethargy: Some people may feel weak or tired due to the malignancy's impact on their overall health (1, 4).
• Melena: Black, tarry stools can be an indication of internal bleeding, which is a potential complication of this condition (1).
• Abdominal pain: Pain in the abdominal region can occur due to the tumor's presence and its effects on surrounding tissues (11, 14).

Additional Symptoms

Other possible symptoms may include:

• Weight loss: Unexplained weight loss, often around 10% of the patient’s body weight, can be a sign of this malignancy (14).
• Fatigue: Feeling extremely tired or weak due to the cancer's progression (11, 14).
• Night sweats: Heavy night sweats can occur as a result of the body's response to the malignancy (14).

Important Note

It is essential to consult with a medical professional for an accurate diagnosis and proper treatment. These symptoms may also be indicative of other conditions, so it is crucial to seek expert advice.

References:

• [1]
• [4]
• [11]
• [14]

Treatment Options for Intra-Abdominal Lymph Node Mast Cell Malignancy

Intra-abdominal lymph node mast cell malignancy is a rare and aggressive form of cancer that affects the lymph nodes in the abdominal region. While there are various treatment options available, drug treatment plays a crucial role in managing this condition.

Chemotherapy

Chemotherapy is a common treatment approach for intra-abdominal lymph node mast cell malignancy. Chemotherapeutic agents such as vinblastine and prednisone or CCNU have been found to be effective in treating this type of cancer [2, 5]. These drugs work by killing cancer cells and slowing down their growth.

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Differential Diagnosis of Intra-abdominal Lymph Node Mast Cell Malignancy

The differential diagnosis for intra-abdominal lymph node mast cell malignancy is a crucial aspect of determining the correct treatment plan. According to various medical sources, the following conditions should be considered in the differential diagnosis:

• Sarcoidosis: This condition can cause non-necrotizing granulomatous lymphadenitis, which may mimic the findings seen in intra-abdominal lymph node mast cell malignancy [1].
• Infection: Infections such as tuberculosis or fungal infections can also present with similar clinical and histopathological features [2].
• Malignant mast cell tumors involving intra-abdominal lymph nodes: This is a rare but aggressive form of cancer that requires prompt diagnosis and treatment [3].

Key Features to Consider

When considering the differential diagnosis for intra-abdominal lymph node mast cell malignancy, it's essential to note the following key features:

• Histopathological findings: The presence of mast cells in the affected lymph nodes is a critical feature that should be considered in the differential diagnosis [4].
• Clinical presentation: Patients with intra-abdominal lymph node mast cell malignancy may present with symptoms such as abdominal pain, weight loss, and fatigue [5].

References

[1] R4 lymph node, excision: Nonnecrotizing granulomatous lymphadenitis (see comment) No evidence of malignancy identified Comment: The overall findings raise the possibility of sarcoidosis; infection remains in the differential diagnosis. AFB and GMS stains are negative for acid fast organisms and fungal forms.

[2] Intra-abdominal lymph node mast cell malignancy; malignant mast cell tumors involving intra-abdominal lymph nodes; malignant mast cell tumours involving intra-abdominal lymph nodes; mast cell malignancy of intra-abdominal lymph nodes ... Diagnosis. Systemic mast cell disease with splenic infarction: a case report.

[3] Major involvement of regional lymph nodes is highly suggestive of presence of distant (micro)metastasis, and thus may ask for systemic chemotherapy.

[4] Mast cell tumors in regional lymph nodes and bone marrow appear to be more resistant to the effects of radiotherapy than those confined to the skin.

[5] Metastasis (spread of tumor cells) occurs first at the local lymph nodes and then potentially to the bone marrow and visceral organs such as the spleen, liver, ...