obsolete skin fibrous tissue neoplasm

Based on the provided context, it appears that there are several types of skin fibrous tissue neoplasms with varying signs and symptoms.

• Dermatofibrosarcoma protuberans is a slow-growing tumor of the fibrous tissue beneath the skin, usually in the trunk or limbs. It grows into nearby tissues but rarely spreads to distant sites [11].
• Fibromatosis is characterized by an infiltrative growth pattern and frequent local recurrence. The cause of fibromatosis is often unknown [5].
• Solitary fibrous tumor, when present in the skin, can be asymptomatic or may cause symptoms such as painless lumps or swelling under the skin, which can press on nerves, organs, or blood vessels causing pain or weakness [6].

It's worth noting that these neoplasms are relatively rare and their signs and symptoms might not be well-documented in modern medical literature.

The main clinical cutaneous manifestations of brownish to grayish hyperpigmentation of the skin, rapid tanning with minimal exposure to the sun is also mentioned [1]. However, it's unclear if this is related to any specific type of fibrous tissue neoplasm.

It's also worth mentioning that the exact cause and symptoms of these neoplasms can vary depending on their location and type.

Based on the provided context, it appears that you are looking for diagnostic tests related to an obsolete skin fibrous tissue neoplasm.

According to search result [10], Solitary fibrous tumors are soft tissue tumors. They can form anywhere in your body. Most are noncancerous but, rarely, they can be cancerous. However, since the question specifies "obsolete", it is likely referring to a rare or outdated condition.

Search result [3] mentions that solitary fibrous tumors of the head and neck region are rare and most commonly benign. The diagnosis depends on microscopic and immunohistochemical features.

For diagnostic tests, search result [7] states that Diagnosis of solitary fibrous tumors requires tissue sampling and staining for immunohistochemical markers. Management of these tumors is based on wide resection with clear margins.

Additionally, search result [4] suggests that Dynamic US examination while applying either different degrees of pressure with the probe or finger palpation or manual mobilization of the skin is essential in evaluating soft tissue lesions, including solitary fibrous tumors.

It's worth noting that the term "obsolete" might be referring to a specific type of skin fibrous tissue neoplasm that has been largely replaced by more modern classifications. However, based on the provided context, it seems that solitary fibrous tumors are still considered relevant in medical literature.

Here are some diagnostic tests that may be relevant:

• Tissue sampling and staining for immunohistochemical markers (search result [7])
• Dynamic US examination while applying different degrees of pressure with the probe or finger palpation or manual mobilization of the skin (search result [4])
• Microscopic examination of conventionally stained sections at low magnification (search result [15])

Please note that these tests may not be specific to an "obsolete" condition, but rather general diagnostic approaches for soft tissue tumors.

Based on the search results, it appears that there are several types of skin fibrous tissue neoplasms that have been treated with various drugs.

• Pazopanib: This drug is approved for the treatment of patients with advanced soft tissue sarcoma in Europe, except for patients with the histological subtype dermatofibrosarcoma protuberans (DFSP) [4].
• Tyrosine kinase inhibitors (TKIs): TKIs are currently considered only in adult patients with DFSP, based on clinical trials [2].

However, it's essential to note that these treatments may not be applicable to all types of skin fibrous tissue neoplasms. For example:

• Solitary fibrous tumors: While surgery is the primary treatment for solitary fibrous tumors, there is no mention of drug treatment in the search results.
• Benign fibrous histiocytoma (BFH): BFH is typically treated with surgical excision, and there is no indication that drug treatment is a standard approach.

In summary, while pazopanib and TKIs have been used to treat certain types of skin fibrous tissue neoplasms, such as DFSP, the effectiveness and safety of these treatments may vary depending on the specific type of tumor. Further research would be necessary to determine the optimal treatment approach for each individual case.

References:

[2] - Based on the results of clinical trials, the use of TKIs in the treatment of DTF is currently considered only in adult patients [2]. [4] - In Europe, pazopanib is approved for the treatment of patients with advanced soft tissue sarcoma, except for patients with the histological subtype DFSP [4].

The differential diagnosis for an obsolete skin fibrous tissue neoplasm involves considering various benign and malignant conditions that may present similarly.

• Benign fibrous histiocytoma (BFH): This is a common, solitary polypoid or flat lesion found in the extremities of young to middle-aged adults, more frequently females. BFH can be multiple, especially in immunosuppressed individuals [4].
• Dermatofibrosarcoma protuberans (DFSP): A low-grade sarcoma that typically arises in the dermis and infiltrates subcutaneous adipose tissue. It is characterized by monomorphic spindle cells with fat entrapment in a honeycomb pattern, but lacks significant atypia [2].
• Solitary fibrous tumor (SFT): A distinct soft tissue neoplasm associated with NAB2-STAT6 gene fusion. SFT can be challenging to diagnose due to its variable histopathology and potential for malignant transformation [7].

Other conditions that may be considered in the differential diagnosis of obsolete skin fibrous tissue neoplasms include:

• Nodular fasciitis: A benign, self-limiting lesion characterized by spindle cells and a storiform pattern.
• Fibroma of tendon sheath: A rare, benign tumor that can mimic SFT or BFH in its histopathology.
• Undifferentiated pleomorphic sarcoma (UPS): A malignant condition that may be considered in the differential diagnosis due to its variable morphology.

It is essential to consider these conditions and their characteristic features when evaluating an obsolete skin fibrous tissue neoplasm. A thorough examination of the tumor's histopathology, clinical presentation, and patient history can help guide the differential diagnosis [13][14].

References: [2] Dermatofibrosarcoma protuberans (DFSP): Lower mitotic activity ... [4] Briefly, benign fibrous histiocytoma is a tumour most commonly encountered as a solitary polypoid, flat or depressed lesion in the extremities of young to middle-aged adults. [7] Solitary fibrous tumor (SFT): A distinct soft tissue neoplasm associated with NAB2-STAT6 gene fusion. [13] The only other real differential diagnosis is so-called 'malignant fibrous histiocytoma' (undifferentiated pleomorphic sarcoma): whatever the latter may be, ... [14] The differential diagnosis of desmoplastic fibroblastoma includes entities both benign and malignant.