Discuss This Drug

pazopanib

CHEBI:CHEBI_71219

Definition

A pyrimidine that is 5-(pyrimidin-2-yl}amino-2-methylbenzenesulfonamide substituted at position 4 by a (2,3-dimethylindazol-6-yl)(methyl)amino group. Used as its hydrochloride salt for treatment of kidney cancer.

Chemical Information

Molecular Formula
C21H23N7O2S
Molecular Mass
437.520
Charge
0
SMILES
C1=C(C(=CC(=C1)NC=2N=CC=C(N2)N(C=3C=CC=4C(C3)=NN(C4C)C)C)S(N)(=O)=O)C
InChI
InChI=1S/C21H23N7O2S/c1-13-5-6-15(11-19(13)31(22,29)30)24-21-23-10-9-20(25-21)27(3)16-7-8-17-14(2)28(4)26-18(17)12-16/h5-12H,1-4H3,(H2,22,29,30)(H,23,24,25)
InChIKey
CUIHSIWYWATEQL-UHFFFAOYSA-N

Alternative Names

  • 5-({4-[(2,3-dimethyl-2H-indazol-6-yl)(methyl)amino]pyrimidin-2-yl}amino)-2-methylbenzenesulfonamide
  • GW 78603
  • GW786034
  • pazopanib
  • pazopanibum

Treatment Applications

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

core#notation
CHEBI:71219
oboInOwl#hasDbXref
Wikipedia:Pazopanib
DRON_00010000
714438

Additional References

Wikipedia:Pazopanib

🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.

Additional Attributes

core#notation
CHEBI:71219
pharm_class_moa
Protein Kinase Inhibitors [MoA]
pharm_class
Protein Kinase Inhibitors [MoA]
nui
N0000187062
active_ingredient_strength
75 kg/75kg
pharm_class_epc
Kinase Inhibitor [EPC]
active_ingredient_name
PAZOPANIB
upc
0360505477951
22-rdf-syntax-ns#type
http://www.w3.org/2002/07/owl#Class
rxcui
867506
listing_expiration_date
20241231
route
ORAL
labeler_name
ZHEJIANG LEPU PHARMACETICAL CO., LTD.
manufacturer_name
Apotex Corp.
marketing_start_date
20091019
package_marketing_start_date
19-OCT-09
spl_id
c212b258-4ef8-4f6b-84a8-6e701555c076
package_ndc
53296-0125-0
package_description
75 kg in 1 DRUM (53296-0125-0)
unii
7RN5DR86CK
spl_set_id
eeaaaf38-fb86-4d9f-a19d-0f61daac2fd7
oboInOwl#hasOBONamespace
chebi_ontology
oboInOwl#hasDbXref
Wikipedia:Pazopanib
DRON_00010000
714438
oboInOwl#id
CHEBI:71219
brand_name
VOTRIENT
brand_name_base
VOTRIENT
product_type
BULK INGREDIENT
marketing_category
BULK INGREDIENT FOR HUMAN PRESCRIPTION COMPOUNDING
dosage_form
POWDER
generic_name
Pazopanib
product_ndc
53296-0125
application_number
NDA022465
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_65207
oboInOwl#inSubset
http://purl.obolibrary.org/obo/chebi#3_STAR
chebi#is_conjugate_base_of
http://purl.obolibrary.org/obo/CHEBI_71218
has_treatment
http://purl.obolibrary.org/obo/DOID_11294
rdf-schema#range
https://w3id.org/def/predibionto#has_drug_113601
rdf-schema#domain
https://w3id.org/def/predibionto#has_side_effect33291
chebi#is_conjugate_acid_of
http://purl.obolibrary.org/obo/CHEBI_71218
owl#annotatedSource
t280266
owl#someValuesFrom
t1029370