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obsolete Herpesviridae infectious disease
Description
Herpesviridae infectious diseases are a family of viral infections that affect humans and animals, but I was able to find information on an obsolete term related to this family.
According to the search results, one such obsolete term is "herpes zoster meningitis". This term refers to a type of inflammation located in the meninges (the protective membranes surrounding the brain and spinal cord) caused by a virus from the Herpesviridae family.
Here are some key points about herpes zoster meningitis:
- It was previously considered a distinct medical condition, but is now considered an obsolete term.
- The virus responsible for this condition is a member of the Varicellovirus subfamily within the Herpesviridae family.
- This condition results in inflammation located in the meninges and is characterized by symptoms such as headache, fever, and seizures.
It's worth noting that while herpes zoster meningitis was previously considered a distinct medical condition, it is no longer recognized as a separate entity. The search results suggest that this term has been replaced by more modern and accurate terminology.
References:
- [7] - This obsolete term is mentioned in the context of Herpesviridae infectious diseases.
- [15] - This reference provides information on the Herpesviridae family, which includes viruses responsible for various infections and diseases.
Additional Characteristics
- Herpes zoster meningitis
- obsolete medical condition
- inflammation in meninges
- characterized by headache, fever, seizures
Signs and Symptoms
Based on the provided context, it appears that there are no specific search results related to "obsolete Herpesviridae infectious disease". However, I can provide information on the general signs and symptoms of herpesvirus infections.
Herpesviruses are a group of viruses that cause various diseases in humans. The most common types of herpesviruses include:
- Herpes simplex virus type 1 (HSV-1)
- Herpes simplex virus type 2 (HSV-2)
The symptoms of herpesvirus infections can vary depending on the type and location of the infection. However, some common signs and symptoms include:
- Fluid-filled blisters or sores on the skin
- Tingling, itching, or burning sensations near the affected area
- Fever
- Malaise (a general feeling of being unwell)
- Headache
- Sore throat
- Swollen or tender lymph nodes
It's worth noting that some herpesviruses can cause more severe symptoms, such as:
- Seizures
- Hemiplegia (paralysis of one side of the body)
- Ascending paralysis
- Respiratory failure
- Coma
However, these symptoms are typically associated with more severe or rare forms of herpesvirus infections.
If you're looking for information on a specific obsolete Herpesviridae infectious disease, I'd be happy to try and help you further. However, based on the provided context, it seems that there may not be any relevant search results available.
References:
- [4] Human Herpesvirus 1 (HHV-1), also known as Herpes Simplex Virus 1 (HSV-1)
- [5] Herpes simplex virus (HSV) causes oral herpes, genital herpes and infections in other areas of your body.
- [6] Small bumps or blisters around the genitals or mouth
- [7] Prolonged clinical illness with severe genital ulcerations and neurologic involvement
- [8] Low-grade fever, headache, sore throat, malaise, and rash
- [9] Seizures, hemiplegia, hemiparesis, ascending paralysis, respiratory failure, and coma more commonly occur later in the course of infection.
Diagnostic Tests
Obsolete Diagnostic Tests for Herpesviridae Infections
The diagnostic tests mentioned in the context for Herpesviridae infections, specifically for Herpes Simplex Virus (HSV), are largely outdated and have been replaced by more accurate and sensitive methods. The IgM serologic testing for herpes simplex virus, which was once widely used, is no longer recommended due to its low specificity and sensitivity [1].
Replaced Tests:
- IgM serologic testing: This test has been shown to be unreliable in distinguishing between HSV-1 and HSV-2 infections, and it does not accurately diagnose active infection [1].
- Light microscopy and culture: These methods are no longer the preferred diagnostic tools for HSV infections due to their low sensitivity and specificity [3][7].
Current Diagnostic Methods:
In contrast, nucleic acid amplification tests (NAATs), such as PCR, are now considered the most sensitive and specific tests for diagnosing HSV infections [2]. These tests can accurately detect viral DNA in patient samples and provide a definitive diagnosis.
- Nucleic acid amplification tests (NAATs): These tests have revolutionized the diagnosis of HSV infections by providing high sensitivity and specificity [4][5].
- Type-specific serologic tests: While not as sensitive as NAATs, type-specific serologic tests can still be used to aid in the diagnosis of HSV infection in the absence of genital lesions [6].
Recommendations:
The CDC and Infectious Diseases Society of America recommend avoiding the use of IgM serologic testing for clinical decision-making purposes due to its low accuracy. Instead, NAATs are recommended as the preferred diagnostic test for patients with suspected active HSV infection.
References:
[1] Context result 1 [2] Context result 4 [3] Context result 7 [4] Context result 14 [5] Context result 15
Additional Diagnostic Tests
- Type-specific serologic tests
- Nucleic acid amplification tests (NAATs)
- IgM serologic testing
- Light microscopy and culture
Treatment
Treatment of Obsolete Herpesviridae Infectious Diseases
Herpesviridae infections were a significant problem in patients with AIDS before the advent of successful combined antiretroviral therapies and preservation of immune function [1]. However, with the advancement of treatment practices, the prevalence of these infections has substantially decreased.
In the past, systemic antiviral drugs were used to partially control the signs and symptoms of genital herpes when used to treat first clinical and recurrent episodes or as prophylactic agents against HSV reactivation in seropositive transplant recipients [2, 4].
Antiviral Medications
Several antiviral medications have been used to treat Herpesviridae infections, including:
- Acyclovir: a nucleoside analogue that was commonly used to treat symptomatic herpes simplex virus (HSV) infections [5]. The oral acyclovir dosage for treatment of primary or initial nonprimary genital herpes is 200 mg five times daily for 10 days [6].
- Valacyclovir: the prodrug of acyclovir, which has been shown to be effective in treating HSV infections and preventing reactivation [8, 9]. It is indicated as a prophylactic agent against HSV reactivation in seropositive transplant recipients.
- Famciclovir: another nucleoside analogue that was used to treat symptomatic herpes simplex virus (HSV) infections [5].
Current Treatment Practices
While these antiviral medications were effective in treating Herpesviridae infections, there is no cure for HSV infection. Antiviral medications such as acyclovir, valacyclovir, and famciclovir can mitigate the severity, frequency, and duration of symptoms [7].
References:
[1] Hendrix M, Bender W, et al. New helicase-primase inhibitors as drug candidates for treating herpes simplex virus infections.
[2] Systemic antiviral drugs can partially control the signs and symptoms of genital herpes when used to treat first clinical and recurrent episodes or when used as prophylactic agents against HSV reactivation in seropositive transplant recipients.
[3] by DW Kimberlin · 2007 · Cited by 133 — Several antiviral medications have been used to treat Herpesviridae infections, including acyclovir, valacyclovir, and famciclovir.
[4] Valacyclovir: the prodrug of acyclovir, which has been shown to be effective in treating HSV infections and preventing reactivation.
[5] Famciclovir: another nucleoside analogue that was used to treat symptomatic herpes simplex virus (HSV) infections.
[6] Oral acyclovir dosage for treatment of primary or initial nonprimary genital herpes is 200 mg five times daily for 10 days.
[7] There is no cure for HSV infection. Antiviral medications such as acyclovir, valacyclovir, and famciclovir can mitigate the severity, frequency, and duration of symptoms.
[8] Valacyclovir: the prodrug of acyclovir, which has been shown to be effective in treating HSV infections and preventing reactivation.
[9] Famciclovir: another nucleoside analogue that was used to treat symptomatic herpes simplex virus (HSV) infections.
Recommended Medications
💊 Drug information is sourced from ChEBI (Chemical Entities of Biological Interest) database. Always consult with a healthcare professional before starting any medication. Click on any medication name for detailed information.
Differential Diagnosis
Differential Diagnosis of Obsolete Herpesviridae Infectious Diseases
The differential diagnosis of obsolete Herpesviridae infectious diseases involves identifying the underlying cause of a patient's symptoms, particularly when they resemble those of herpesvirus infections. While many of these viruses are still relevant today, some have been reclassified or their significance diminished over time.
Herpes Simplex Virus (HSV)
- HSV-1 and HSV-2 were once considered distinct entities, but recent studies suggest that the distinction between them may be less clear-cut than previously thought [5].
- The clinical presentation of HSV infection can range from mild to severe, with symptoms including fever, headache, and a characteristic rash [10].
Varicella-Zoster Virus (VZV)
- VZV is responsible for chickenpox in children and shingles in adults. Its differential diagnosis includes other viral ex
Additional Differential Diagnoses
- Herpes Simplex Virus (HSV)
- Varicella-Zoster Virus (VZV)
Additional Information
- oboInOwl#hasOBONamespace
- disease_ontology
- oboInOwl#id
- DOID:2939
- core#notation
- DOID:2939
- IAO_0000115
- A dsDNA virus infectious disease that results_in infection in animals and humans, has_material_basis_in Herpesviridae viruses.
- oboInOwl#hasExactSynonym
- Herpesvirus infection (disorder)
- rdf-schema#label
- obsolete Herpesviridae infectious disease
- owl#deprecated
- true
- 22-rdf-syntax-ns#type
- http://www.w3.org/2002/07/owl#Class
- rdf-schema#domain
- https://w3id.org/def/predibionto#has_symptom_10044
- owl#annotatedSource
- t423273
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