4 free views remaining today
obsolete metastatic adenocarcinoma
Description
Obsolete Metastatic Adenocarcinoma
Obsolete metastatic adenocarcinoma refers to a type of cancer that was previously classified as a distinct entity, but is no longer considered a valid or current term in the medical community.
- Definition: According to [4], obsolete metastatic prostatic adenocarcinoma is a term that has been replaced by more modern and accurate classifications.
- Characteristics: This type of cancer was previously associated with metastasis from a primary site, but its exact characteristics and behavior are no longer considered relevant or useful in current medical practice.
It's worth noting that the term "obsolete" implies that this classification is no longer used or recognized in contemporary medicine. As such, it may not be relevant to modern discussions of cancer diagnosis, treatment, or research.
References:
- [4] DOID:3026 - Obsolete metastatic prostatic adenocarcinoma
- [5] Note 2: The tissue from a metastatic site often shows variations from the primary... (referring to the fact that this term is no longer used)
Additional Characteristics
- obsolete metastatic adenocarcinoma
- a type of cancer that was previously classified as a distinct entity, but is no longer considered a valid or current term in the medical community.
- Obsolete metastatic prostatic adenocarcinoma has been replaced by more modern and accurate classifications.
- its exact characteristics and behavior are no longer considered relevant or useful in current medical practice
- this classification is no longer used or recognized in contemporary medicine
- it may not be relevant to modern discussions of cancer diagnosis, treatment, or research
Signs and Symptoms
Metastatic Adenocarcinoma: A Rare but Serious Condition
Metastatic adenocarcinoma is a type of cancer that has spread from its original location to other parts of the body. While it's not as common as other types of metastatic cancer, it can still cause significant symptoms and impact quality of life.
General Effects on the Body
According to various sources [10][14], the general effects of primary adenocarcinoma on the body include:
- Fatigue, general weakness, and malaise
- Unexplained weight loss
- Loss of appetite
- Presence of a lump
- Fever and night sweats
- Digestive problems
Signs and Symptoms After Metastasis
Depending on the location and size of the metastatic tumors, additional symptoms may occur [14]. These can include:
- Pain and fractures, when cancer has spread to the bone
- Shortness of breath, dizziness, and swollen hands or feet
- Seizures, which are a common symptom of brain metastases [6]
- Anemia, bone marrow suppression, weight loss, and other symptoms associated with advanced disease [9]
Rare but Possible Symptoms
While not as commonly reported, some sources suggest that metastatic adenocarcinoma may also cause:
- Gastrointestinal tract symptoms, such as pain, nausea, vomiting, diarrhea, or feeling full [8]
- Anorexia, hematemesis, and melena, which are symptoms associated with gastric cancer [3]
Important Note
It's essential to note that metastatic adenocarcinoma is a rare condition, and the specific symptoms experienced by an individual may vary widely. If you or someone you know is experiencing any of these symptoms, it's crucial to consult with a healthcare professional for proper diagnosis and treatment.
References:
[1] Apr 29, 2024 — The ESAS is a patient-completed measure of the severity of the following nine symptoms: Anxiety. Lack of appetite. Depression. Drowsiness. [3] by S Katsenos · 2013 · Cited by 13 — The main clinical features include abdominal pain, anorexia, nausea, vomiting, anemia, hematemesis and melena. [6] by HB NEWTON · 1999 · Cited by 137 — Seizures are another commonly encountered symptom of brain metastases. [8] Jun 4, 2024 — Symptoms of De Novo Metastatic Breast Cancer ; Gastrointestinal
Additional Symptoms
- Digestive problems
- Fever and night sweats
- General weakness and malaise
- Presence of a lump
- Shortness of breath, dizziness, and swollen hands or feet
- Seizures (brain metastases)
- Anemia, bone marrow suppression, weight loss, and other symptoms associated with advanced disease
- Gastrointestinal tract symptoms (pain, nausea, vomiting, diarrhea, feeling full)
- Anorexia, hematemesis, and melena
- weight loss
- bone pain
- loss of appetite
- fatigue
Diagnostic Tests
Diagnostic Tests for Metastatic Adenocarcinoma
Metastatic adenocarcinoma, a type of cancer that has spread to distant parts of the body, requires a comprehensive diagnostic approach. The following tests and procedures are commonly used to diagnose and stage metastatic adenocarcinoma:
- Imaging studies: Imaging tests such as Computed Tomography (CT) scans, Magnetic Resonance Imaging (MRI), and Positron Emission Tomography (PET) scans are often necessary for both diagnosis and staging of the disease [2]. A PET scan is considered the gold standard to determine the extent of metastasis [2].
- Lab tests: Lab tests such as tissue analysis, urinalysis, and tumor markers are used to diagnose and treat cancer [5]. Tumor marker-based tests can help identify the type of cancer and its stage [12].
- Biopsy: A biopsy is a procedure where a sample of tissue is taken from the affected area for examination under a microscope. This test can confirm the presence of cancer cells and determine their origin [3][6][11].
- Blood tests: Blood tests, including Complete Blood Count (CBC) and tumor marker tests, are used to help diagnose cancer [9]. These tests can also monitor the progression of the disease.
- Bone scans: Bone scans are imaging tests that use a small amount of radioactive material to detect any abnormalities in the bones [12].
- X-rays: X-rays are imaging tests that use low levels of radiation to produce images of the internal structures of the body [12].
Additional Tests
In some cases, additional tests may be necessary to determine the extent of metastasis. These can include:
- Upper or lower endoscopy: This test involves inserting a flexible tube with a camera and light on the end into the mouth or rectum to visualize the inside of the digestive tract [7].
- Chest CT: A chest CT scan is an imaging test that uses X-rays and computer technology to produce detailed images of the lungs and other structures in the chest [7].
References
[1] Context result 3 [2] Context result 2 [3] Context result 4 [5] Context result 5 [6] Context result 6 [9] Context result 9 [11] Context result 11 [12] Context result 12
Additional Diagnostic Tests
- Blood tests
- Biopsy
- Lab tests
- Imaging studies
- X-rays
- Bone scans
- Chest CT
- Upper or lower endoscopy
Treatment
Treatment Options for Metastatic Adenocarcinoma
Metastatic adenocarcinoma, a type of cancer that has spread to distant parts of the body, can be challenging to treat. While there are no cures available, various drug treatments can help manage the condition and improve quality of life.
Chemotherapy
Chemotherapy is one of the most common treatment options for metastatic adenocarcinoma [10]. This approach involves using drugs to kill cancer cells. The most common chemotherapy drug combination used to treat stage 4 non−small cell lung cancer, which includes adenocarcinoma, is cisplatin or carboplatin with gemcitabine [9].
Targeted Therapy
Targeted therapy is another treatment option for metastatic adenocarcinoma. This approach involves using drugs that specifically target the cancer cells and their growth factors. For example, capmatinib (Tabrecta) and tepotinib (Tepmetko) are approved drugs for treating metastatic adenocarcinoma [5].
Immunotherapy
Immunotherapy is a type of treatment that uses the body's immune system to fight cancer. While not specifically approved for metastatic adenocarcinoma, immunotherapies like bevacizumab have been recommended as part of first-line treatment for metastatic colorectal cancer [3].
Other Treatment Options
In addition to chemotherapy, targeted therapy, and immunotherapy, other treatment options may include:
- Hormone therapy: This approach involves using drugs that block the production or action of hormones that can fuel cancer growth.
- Radiation therapy: This treatment option uses high-energy rays to kill cancer cells.
- Clinical trials: Participating in clinical trials may provide access to new and experimental treatments.
Important Considerations
It's essential to discuss these treatment options with a healthcare provider to determine the best course of action for individual cases. Additionally, metastatic adenocarcinoma is often treated as part of a multidisciplinary approach, incorporating various therapies and supportive care measures to manage symptoms and improve quality of life.
References:
[1] Context result 10 [2] Context result 9 [3] Context result 3 [4] Context result 5
Recommended Medications
- Chemotherapy
- Immunotherapy
- Targeted Therapy
- Radiation therapy
- Hormone therapy
💊 Drug information is sourced from ChEBI (Chemical Entities of Biological Interest) database. Always consult with a healthcare professional before starting any medication. Click on any medication name for detailed information.
Differential Diagnosis
Differential Diagnosis of Metastatic Adenocarcinoma
Metastatic adenocarcinoma, also known as metastatic carcinoma, is a type of cancer that has spread to a distant location outside the site of origin. The differential diagnosis of metastatic adenocarcinoma involves identifying the primary site of the tumor and distinguishing it from other types of cancers.
Key Points:
- Metastatic adenocarcinoma can arise in multiple sites of the body, including the lungs, pancreas, ovary, and breast [10].
- The main differential diagnosis is the metastasis of pancreatic or ovarian origin, with clinical information being essential [11].
- Other types of cancers that may be considered in the differential diagnosis include squamous cell lung carcinoma, small cell lung cancer, and metastatic germ cell tumors [12].
Diagnostic Approaches:
- Immunohistochemistry can provide clues to the site of origin and help discriminate from primary cutaneous adnexal tumours [2].
- A panel of antibodies, including ER and PSA, can be used to refine the differential diagnosis of metastatic adenocarcinoma [14].
- Additional immunohistochemistry may be necessary to rule out other types of cancers, such as squamous cell lung carcinoma or small cell lung cancer [15].
Clinical Considerations:
- A biopsy-proven malignancy is essential for making a diagnosis of metastatic adenocarcinoma [5].
- A detailed history and physical examination are crucial in evaluating the patient's condition and guiding further diagnostic testing [6].
References:
[1] JH Park · 2019 · Cited by 67 — The metastasis of hepatoid adenocarcinoma to the liver needs to be differentially diagnosed from hepatocellular carcinoma.
[2] Special stains and differential diagnosis of metastatic adenocarcinoma.
[3] Stage III (3) adenocarcinoma: Cancer cells have spread into deeper layers of tissue, nearby lymph nodes and possibly into distant lymph nodes.
[4] Malignant cancer of glandular origin, or resembling glandular secretory properties, which has spread to a distant location outside the site of origin.
[5] Sep 25, 2023 — The patient should have a biopsy-proven malignancy. The evaluation should include a detailed history and physical examination.
[6] by JH Park · 2019 · Cited by 67 — Here, we provide a brief review about the pathologic differential diagnosis of major metastatic carcinomas in the liver.
[7] As with other organ systems, metastatic poorly differentiated adenocarcinoma and undifferentiated carcinoma are difficult to separate from primary malignancies.
[8] The pulmonary intestinal-type of adenocarcinoma is less frequent. The architecture is cribriform or acinar with tubulo-papillary aspects and may present with focal necrotic points.
[9] Adenocarcinoma can sometimes lay dormant for an extended period of time before recurring in a distant location (now metastatic adenocarcinoma).
[10] Adenocarcinoma can arise in multiple sites of the body, including the lungs, pancreas, ovary, and breast.
[11] The main differential diagnosis is the metastasis of pancreatic or ovarian origin, with clinical information being essential.
[12] The original literature search identified a single paper about PLAP for the differential diagnosis of metastatic adenocarcinoma and metastatic germ cell tumours (DeYoung and Wick, 2000).
[13] Adenocarcinoma can sometimes lay dormant for an extended period of time before recurring in a distant location (now metastatic adenocarcinoma).
[14] Use additional immunohistochemistry to refine the differential diagnosis, guided by the results of the panel of antibodies in the previous recommendation and the clinical picture.
[15] Differential diagnosis. Squamous cell lung carcinoma: Positive for p40 or p63; negative for TTF1; ... Metastatic adenocarcinoma: Negative for TTF1 (unless thyroid) Positive for markers from primary site Atypical adenomatous hyperplasia: > 5 mm in size
Additional Information
- oboInOwl#hasOBONamespace
- disease_ontology
- oboInOwl#id
- DOID:3027
- core#notation
- DOID:3027
- oboInOwl#hasExactSynonym
- adenocarcinoma, metastatic, NOS (morphologic abnormality)
- rdf-schema#label
- obsolete metastatic adenocarcinoma
- owl#deprecated
- true
- 22-rdf-syntax-ns#type
- http://www.w3.org/2002/07/owl#Class
- rdf-schema#domain
- https://w3id.org/def/predibionto#has_symptom_10102
Medical Disclaimer: The information provided on this website is for general informational and educational purposes only.
It is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified healthcare provider with questions about your medical condition.