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obsolete neuroepithelial neoplasm

Description

Based on the provided context, it appears that there are several search results related to neuroepithelial neoplasms, including some that mention obsolete terms.

Definition and Context

A neuroepithelial neoplasm is a type of tumor that arises from the neuroepithelial tissues in the nervous system. According to search result [10], it was previously referred to as an "Antiquated" or "Central Nervous System Neuroepithelial Neoplasm of Uncertain Origin".

Obsolescence and Revisions

Search results [14] and [15] mention that some entities, variants, and patterns have been referred to as "not recommended" in the 2016 edition. Additionally, search result [15] states that this entity has been obsoleted from the Orphanet nomenclature of rare diseases.

Current Classification

Search results [11] and [12] mention the latest revisions and updates to CNS tumor classification, including the introduction of molecular diagnostics in CNS tumor classification. However, they do not specifically address the description of obsolete neuroepithelial neoplasms.

Summary

In summary, while there is limited information on the specific topic of "description of obsolete neuroepithelial neoplasm", it appears that this term has been replaced or obsoleted in recent revisions and updates to CNS tumor classification. The current classification and nomenclature for neuroepithelial neoplasms are more focused on molecular diagnostics and updated terminology.

References:

[10] - Nervous System Neoplasm (Antiquated) · Central Nervous System Neuroepithelial Neoplasm of Uncertain Origin [14] - The 2016 edition has added newly recognized neoplasms and has referred to some entities, variants and patterns as “not recommended”. (previously called obsolete) [15] - Oct 14, 2024 — This entity has been obsoleted from the Orphanet nomenclature of rare diseases.

Additional Characteristics

  • Central Nervous System Neuroepithelial Neoplasm of Uncertain Origin
  • not recommended
  • obsoleted from the Orphanet nomenclature of rare diseases

Signs and Symptoms

Based on the provided context, here are the signs and symptoms associated with obsolete neuroepithelial neoplasm:

  • The most common symptoms of these tumors are headache and seizures [1].
  • Other signs include subacutely evolving masses in the posterior fossa, such as pain in the neck, stiff neck, head tilt, and paresthesias in the shoulders, dysphagia [4].
  • Less often, stroke from hemorrhage is a presenting symptom in tumors with the tendency to bleed [8].

It's worth noting that these symptoms can vary depending on the location of the tumor. Additionally, some sources mention that seizures are one of the most frequent presenting symptoms of pediatric brain tumors occurring in 13% of patients [9].

References:

[1] A PERKINS · 2016 · Cited by 262 [4] [8] [9] by IS Fernández · 2017 · Cited by 57

Additional Symptoms

Diagnostic Tests

Diagnostic Tests for Dysembryoplastic Neuroepithelial Tumor (DNET)

Dysembryoplastic neuroepithelial tumor (DNET) is a rare type of low-grade brain tumor that can be challenging to diagnose. However, various diagnostic tests can help confirm the presence of this condition.

  • Imaging Studies: Gadolinium-enhanced magnetic resonance imaging (MRI) is considered the preferred imaging modality for diagnosing suspected brain tumors, including DNET [2]. MRI can show characteristic features such as multicystic lesions with a T1-hypointense and T2-hyperintense appearance [8].
  • Histopathological Examination: A definitive diagnosis of DNET requires histopathological examination of the tumor tissue. This involves careful observation of the entire tissue sample to identify distinctive histologic patterns, which may include a mixture of neuronal and glial cells [10]. Additional immunohistochemical tests may be necessary to confirm the diagnosis in cases with nonspecific or diffuse forms.
  • Clinical Correlation: Clinical correlation is essential to rule out other conditions that may present similarly to DNET. A thorough medical history and physical examination can help identify associated symptoms, such as seizures, which are common in patients with DNET [14].
  • Molecular Testing: Molecular testing can be used to confirm the diagnosis of DNET by identifying specific genetic mutations or markers. However, this is not always necessary for diagnosis.

References:

[2] A PERKINS · 2016 · Cited by 262 — Gadolinium-enhanced magnetic resonance imaging is the preferred imaging modality in the diagnosis of suspected brain tumors.

[8] The typical radiological pattern is a magnetic resonance imaging (MRI) T1-hypointense, T2-, and fluid-attenuated inversion-recovery hyperintense multicystic lesion.

[10] Dysembryoplastic neuroepithelial tumor (DNET) is a distinct type of low-grade glioneuronal tumor.

[14] Keywords: brain tumor, dysembryoplastic neuroepithelial tumor, epilepsy, methionine PET

Additional Diagnostic Tests

  • Molecular Testing
  • Histopathological Examination
  • Gadolinium-enhanced magnetic resonance imaging (MRI)
  • Clinical Correlation

Treatment

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Differential Diagnosis

Differential Diagnosis of Obsolete Neuroepithelial Neoplasm

The differential diagnosis for an obsolete neuroepithelial neoplasm, also known as a dysembryoplastic neuroepithelial tumor (DNET), involves considering various other types of brain tumors that may present with similar characteristics. Some of the key entities to consider in the differential diagnosis include:

  • Ganglioglioma: A ganglioglioma is a type of low-grade glioma that typically presents with calcification and contrast enhancement, which can be distinct from DNETs [10].
  • Pleomorphic Xanthoastrocytoma (PXA): PXA is another type of low-grade glioma that often presents with prominent contrast enhancement and a dural tail sign, which can be confused with DNETs [10].
  • Mixed Glioneuronal Tumors: These tumors are characterized by the presence of both glial and neuronal components, similar to DNETs. However, they may have a more complex histological appearance and can be distinguished from DNETs based on their imaging features [3].
  • Oligodendrogliomas: Oligodendrogliomas are rare in the pediatric population and may present with similar imaging characteristics to DNETs. However, they typically have a more uniform appearance and may not show the same level of calcification as DNETs [7].

Key Imaging Features

When considering the differential diagnosis for an obsolete neuroepithelial neoplasm, it is essential to examine the key imaging features that can help distinguish it from other types of brain tumors. Some of these features include:

  • Calcification: Calcification is a common feature in DNETs and may be seen in up to 50% of cases [10].
  • Contrast Enhancement: Contrast enhancement is more common in gangliogliomas than in DNETs, but can also be seen in PXA [10].
  • Imaging Appearance: The imaging appearance of an obsolete neuroepithelial neoplasm may vary depending on the specific characteristics of the tumor. However, it typically presents as a well-circumscribed lesion with a smooth or lobulated border.

Clinical Considerations

In addition to the imaging features, clinical considerations are also essential when considering the differential diagnosis for an obsolete neuroepithelial neoplasm. Some of these factors include:

  • Age: DNETs are typically diagnosed in children and young adults, whereas other types of brain tumors may present at different ages [13].
  • Location: The location of the tumor can also provide clues about its identity. For example, DNETs are often localized to the primary site of origin, whereas other types of brain tumors may be more diffuse or widespread.

In conclusion, the differential diagnosis for an obsolete neuroepithelial neoplasm involves considering various other types of brain tumors that may present with similar characteristics. By examining key imaging features and clinical considerations, it is possible to distinguish DNETs from other entities and provide a more accurate diagnosis.

Additional Information

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