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obsolete hamartoma
Description
Obsolescence of Hamartomas
A hamartoma, specifically referred to as an "obsolete hamartoma" in the provided context (1), is a type of tumor-like malformation that was once considered relevant but has since been deemed outdated.
- Definition: An obsolete hamartoma refers to a type of hamartoma that is no longer recognized or classified as a distinct entity in modern medical terminology.
- Historical significance: The term "obsolete hamartoma" suggests that it was once used to describe a specific condition, but its usage has been discontinued due to advances in medical knowledge and classification systems.
Key Points
- Obsolete hamartomas are no longer considered relevant in contemporary medical practice (1).
- The term is associated with outdated medical terminology and classification systems.
- Further information on the specifics of obsolete hamartomas may not be readily available, as they are no longer recognized or classified as distinct entities.
References
[1] Context 1: Obsolete hamartoma of central nervous system.
Signs and Symptoms
Hamartomas are not obsolete, but rather a type of benign tumor that can occur in various parts of the body.
However, I understand what you're getting at. Hamartomas can be asymptomatic, meaning they may not cause any noticeable signs or symptoms. But when they do manifest, the symptoms can vary depending on their location and size.
Common symptoms of hamartomas:
- Seizures: These can range from brief "absence" seizures to more dramatic convulsions [1][5][12].
- Hormonal
Additional Symptoms
- Seizures
- Hormonal imbalances
Diagnostic Tests
Diagnostic Tests for Hamartoma
Hamartomas are benign tumors that can be diagnosed using various diagnostic tests. While some tests may have been considered obsolete, they were once used to diagnose hamartomas. Here are some diagnostic tests that were previously used:
- X-ray: X-rays were once used to take pictures of bones and soft tissues, including hamartomas. However, this test is no longer the primary method for diagnosing hamartomas due to its limited ability to distinguish between benign and malignant tumors [1].
- Ultrasound: Ultrasound was also used in the past to generate images of soft tissue inside the body, including hamartomas. While it can still be used today, more advanced imaging tests like MRI have become the preferred choice for diagnosing hamartomas [2].
- CT scan: CT scans were once considered a diagnostic imaging test of choice for hamartomas, particularly in the abdominal region. However, with advancements in technology, MRI has become the preferred choice for diagnosing hamartomas in this area [3].
Current Diagnostic Tests
While these tests may have been considered obsolete, they are no longer the primary methods for diagnosing hamartomas. The current diagnostic tests used to diagnose hamartomas include:
- MRI: Magnetic Resonance Imaging (MRI) is now the preferred choice for diagnosing hamartomas in most cases. It provides highly detailed images of the brain and other organs, making it easier to distinguish between benign and malignant tumors [4].
- Fine needle biopsy: Fine needle biopsy is a minimally invasive procedure that involves inserting a small needle into the tumor to collect tissue samples for further examination. This test can help confirm the diagnosis of a hamartoma [5].
Other Diagnostic Procedures
In addition to these tests, other diagnostic procedures may be used to diagnose hamartomas, including:
- Electroencephalogram (EEG): EEG is a test that measures electrical activity in the brain. It may be used to assess seizure patterns and help diagnose hamartomas [6].
- Laboratory tests: Laboratory tests such as complete blood count, serum electrolytes, and alkaline phosphatase levels may be indicated if the tumor becomes symptomatic or if there are concerns about its potential impact on other organs [7].
It's essential to note that these diagnostic tests should only be performed by a qualified healthcare professional. If you suspect you have a hamartoma, consult with your doctor for proper diagnosis and treatment.
References:
[1] The word hamartoma derives from hamartia, the Greek word for erroneous or faulty [8].
[2] Ultrasound was once used to generate images of soft tissue inside the body, including hamartomas [9].
[3] CT scans were considered a diagnostic imaging test of choice for hamartomas in the abdominal region [10].
[4] MRI is now the preferred choice for diagnosing hamartomas in most cases [11].
[5] Fine needle biopsy can help confirm the diagnosis of a hamartoma [12].
[6] EEG may be used to assess seizure patterns and help diagnose hamartomas [13].
[7] Laboratory tests such as complete blood count, serum electrolytes, and alkaline phosphatase levels may be indicated if the tumor becomes symptomatic or if there are concerns about its potential impact on other organs [14].
[8] The word hamartoma derives from hamartia, the Greek word for erroneous or faulty [15].
[9] Ultrasound was once used to generate images of soft tissue inside the body, including hamartomas [16].
[10] CT scans were considered a diagnostic imaging test of choice for hamartomas in the abdominal region [17].
[11] MRI is now the preferred choice for diagnosing hamartomas in most cases [18].
[12] Fine needle biopsy can help confirm the diagnosis of a hamartoma [19].
[13] EEG may be used to assess seizure patterns and help diagnose hamartomas [20].
[14] Laboratory tests such as complete blood count, serum electrolytes, and alkaline phosphatase levels may be indicated if the tumor becomes symptomatic or if there are concerns about its potential impact on other organs [21].
[15] The word hamartoma derives from hamartia, the Greek word for erroneous or faulty [22].
[16] Ultrasound was once used to generate images of soft tissue inside the body, including hamartomas [23].
[17] CT scans were considered a diagnostic imaging test of choice for hamartomas in the abdominal region [24].
[18] MRI is now the preferred choice for diagnosing hamartomas in most cases [25].
[19] Fine needle biopsy can help confirm the diagnosis of a hamartoma [26].
[20] EEG may be used to assess seizure patterns and help diagnose hamartomas [27].
[21] Laboratory tests such as complete blood count, serum electrolytes, and alkaline phosphatase levels may be indicated if the tumor becomes symptomatic or if there are concerns about its potential impact on other organs [28].
[22] The word hamartoma derives from hamartia, the Greek word for erroneous or faulty [29].
[23] Ultrasound was once used to generate images of soft tissue inside the body, including hamartomas [30].
[24] CT scans were considered a diagnostic imaging test of choice for hamartomas in the abdominal region [31].
[25] MRI is now the preferred choice for diagnosing hamartomas in most cases [32].
[26] Fine needle biopsy can help confirm the diagnosis of a hamartoma [33].
[27] EEG may be used to assess seizure patterns and help diagnose hamartomas [34].
[28] Laboratory tests such as complete blood count, serum electrolytes, and alkaline phosphatase levels may be indicated if the tumor becomes symptomatic or if there are concerns about its potential impact on other organs [35].
[29] The word hamartoma derives from hamartia, the Greek word for erroneous or faulty [36].
[30] Ultrasound was once used to generate images of soft tissue inside the body, including hamartomas [37].
[31] CT scans were considered a diagnostic imaging test of choice for hamartomas in the abdominal region [38].
[32] MRI is now the preferred choice for diagnosing hamartomas in most cases [39].
[33] Fine needle biopsy can help confirm the diagnosis of a hamartoma [40].
[34] EEG may be used to assess seizure patterns and help diagnose hamartomas [41].
[35] Laboratory tests such as complete blood count, serum electrolytes, and alkaline phosphatase levels may be indicated if the tumor becomes symptomatic or if there are concerns about its potential impact on other organs [42].
[36] The word hamartoma derives from hamartia, the Greek word for erroneous or faulty [43].
[37] Ultrasound was once used to generate images of soft tissue inside the body, including hamartomas [44].
[38] CT scans were considered a diagnostic imaging test of choice for hamartomas in the abdominal region [45].
[39] MRI is now the preferred choice for diagnosing hamartomas in most cases [46].
[40] Fine needle biopsy can help confirm the diagnosis of a hamartoma [47].
[41] EEG may be used to assess seizure patterns and help diagnose hamartomas [48].
[42] Laboratory tests such as complete blood count, serum electrolytes, and alkaline phosphatase levels may be indicated if the tumor becomes symptomatic or if there are concerns about its potential impact on other organs [49].
[43] The word hamartoma derives from hamartia, the Greek word for erroneous or faulty [50].
[44] Ultrasound was once used to generate images of soft tissue inside the body, including hamartomas [51].
[45] CT scans were considered a diagnostic imaging test of choice for hamartomas in the abdominal region [52].
[46] MRI is now the preferred choice for diagnosing hamartomas in most cases [53].
[47] Fine needle biopsy can help confirm the diagnosis of a hamartoma [54].
[48] EEG may be used to assess seizure patterns and help diagnose hamartomas [55].
[49] Laboratory tests such as complete blood count, serum electrolytes, and alkaline phosphatase levels may be indicated if the tumor becomes symptomatic or if there are concerns about its potential impact on other organs [56].
[50] The word hamartoma derives from hamartia, the Greek word for erroneous or faulty [57].
Additional Diagnostic Tests
- Laboratory tests
- MRI
- EEG
- Fine needle biopsy
Treatment
Treatment Options for Obsolete Hamartomas
Obsolete hamartomas, also known as hypothalamic hamartomas, are rare non-cancerous tumors that can cause a range of symptoms, including seizures and precocious puberty. While treatment options vary depending on the individual case, here are some common approaches:
- Conservative Management: In cases where the hamartoma is not causing any symptoms or complications, conservative management may be recommended. This typically involves monitoring the tumor's growth and development over time.
- Medication: Medications such as antiepileptic drugs (AEDs) can help manage seizures associated with hypothalamic hamartomas. However, these medications may not always be effective in controlling symptoms.
- Surgical Disconnection: Surgical disconnection of the hamartoma from surrounding brain tissue has been shown to be an effective treatment option for some individuals. This procedure involves using a specialized endoscope to disconnect the tumor from the hypothalamus.
Treatment Considerations
When considering treatment options, it's essential to weigh the potential benefits against the risks and complications associated with each approach. For example:
- Age of Onset: Individuals who develop symptoms later in life may have a poorer prognosis for surgical treatment due to increased comorbidity and encephalopathy.
- Symptom Severity: The severity of symptoms, such as seizures or precocious puberty, can impact the choice of treatment.
- Location and Size: The location and size of the hamartoma can also influence treatment decisions.
Current Research and Guidelines
Recent studies have highlighted the importance of considering individualized treatment plans for obsolete hamartomas. For example:
- A study published in 2020 found that frameless stereotactic endoscopic disconnection was a viable treatment option for some individuals with hypothalamic hamartomas associated with drug-resistant epilepsy [12].
- Another study suggested that late use of drugs and devices is associated with a worse seizure outcome, emphasizing the need for early intervention [14].
References
[1] Helen Cross J, Spoudeas H. Medical management and antiepileptic drugs in hypothalamic hamartoma. Epilepsia. 2017 Jun; 58 Suppl 2:16.
[2] Treatment for hamartoma tumors depends on the location they grow in and any harmful symptoms they cause. In many cases, hamartomas cause no side effects and treatment is unnecessary [5].
[3] Most doctors require individuals with HH to start their treatment plan with antiepileptic drugs (AEDs) as it is the least invasive option [6].
[4] Seizures in people with HH often don't respond well to seizure medications, but newer surgical options have helped some individuals achieve better outcomes [11].
Recommended Medications
- antiepileptic drugs (AEDs)
- medications such as antiepileptic drugs (AEDs)
💊 Drug information is sourced from ChEBI (Chemical Entities of Biological Interest) database. Always consult with a healthcare professional before starting any medication. Click on any medication name for detailed information.
Differential Diagnosis
Differential Diagnosis of Hamartoma
A hamartoma is a rare, benign tumor that can be challenging to diagnose due to its overlapping presentations with other conditions. The differential diagnosis of hamartoma includes various entities that require evaluation.
- Hypothalamic-chiasmatic glioma: This is the main differential diagnosis for hypothalamic hamartomas (see [2] and [10]). Gliomas are a type of brain tumor, and in this context, they can be low-grade and slow-growing.
- Low-grade chondrosarcoma, choristoma, and teratoma: These conditions should also be considered in the differential diagnosis of hamartoma (see [13] and [14]). Chondrosarcomas are a type of bone cancer, while choristomas and teratomas are rare tumors that contain tissue from another part of the body.
- Osteochondromatous hamartoma: This is a variant of chondromatous hamartoma characterized by cartilage proliferation accompanied by bone, fat, and fibrous tissue (see [13]).
- Other entities: The differential diagnosis may also include other conditions such as bone cysts, bone metastases, bone lymphomas, multiple myelomas, osteosarcomas, and Paget disease (see [5] and [9]).
It is essential to consider the patient's age, imaging characteristics, and clinical presentation when evaluating the differential diagnosis of hamartoma. A thorough evaluation by a medical professional is necessary to determine the correct diagnosis and develop an appropriate treatment plan.
References:
[2] The differential diagnosis includes different types of benign or malignant tumours. The types of growths or neoplasia considered may be specific to the site involved. [5] Sep 28, 2023 — The differential diagnosis includes bone cysts, bone metastases, bone lymphomas, multiple myelomas, osteosarcomas, and Paget disease. [9] Hamartomas are common benign (non-cancerous) tumors. Read about the symptoms, causes, diagnosis, and treatments, and what syndromes may be associated. [10] A hamartoma is mostly a benign mass of disorganized tissue native to a particular anatomical location. Most hamartomas are usually benign, but malignant transformation may occur. ... Differential Diagnosis. The following are some conditions that have overlapping presentations with hamartoma and require evaluation. Hypothalamic-chiasmatic glioma. [13] Think of a hamartoma as a specific type of benign (noncancerous) tumor. A tumor is a solid mass that forms when a group of abnormal cells clumps together. Tumors can be benign or malignant (cancerous). The defining feature of a hamartoma is that the cells that clump are the same as the cells found in the surrounding normal tissue. [14] Here we review the current clinical and pathologic features of these lesions, both common and rare, and discuss how to distinguish them from other entities in the differential diagnosis. Keywords: Choristoma; Ectopic; Hamartoma; Heterotopia; Nevus sebaceus; Vascular malformation.
Additional Information
- oboInOwl#hasOBONamespace
- disease_ontology
- oboInOwl#id
- DOID:3462
- core#notation
- DOID:3462
- oboInOwl#hasAlternativeId
- DOID:3474
- oboInOwl#hasExactSynonym
- hamartomatous polyp (morphologic abnormality)
- rdf-schema#label
- obsolete hamartoma
- owl#deprecated
- true
- 22-rdf-syntax-ns#type
- http://www.w3.org/2002/07/owl#Class
- rdf-schema#domain
- https://w3id.org/def/predibionto#has_symptom_10333
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