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obsolete childhood soft tissue sarcoma
Description
Obsolete Childhood Soft Tissue Sarcoma: A Rare Cancer Type
Obsolete childhood soft tissue sarcoma, also known as pediatric sarcoma of the soft tissue, is a rare and aggressive type of cancer that affects children. It is characterized by the growth of abnormal cells in the soft tissues of the body, such as muscles, tendons, and fat.
Definition and Prevalence
According to various sources [2, 8], obsolete childhood soft tissue sarcoma is a type of cancer that primarily affects children and adolescents. The exact prevalence of this cancer type is not well-documented, but it is considered to be relatively rare compared to other types of childhood cancers.
Characteristics and Symptoms
The characteristics and symptoms of obsolete childhood soft tissue sarcoma can vary depending on the specific location and type of tumor [3]. However, common symptoms include:
- A lump or swelling in the affected area
- Pain or tenderness in the affected area
- Weakness or fatigue
- Weight loss
Grading and Staging
The grading and staging of obsolete childhood soft tissue sarcoma are critical factors in determining the prognosis and treatment plan for affected children [4]. The Pediatric Oncology Group (POG) system is often used to grade these tumors, with higher grades indicating more aggressive tumor behavior.
Treatment Options
Treatment options for obsolete childhood soft tissue sarcoma typically involve a combination of surgery, chemotherapy, and radiation therapy [5, 6]. The specific treatment plan will depend on the individual child's needs and the stage of the cancer.
In summary, obsolete childhood soft tissue sarcoma is a rare and aggressive type of cancer that affects children. It is characterized by the growth of abnormal cells in the soft tissues of the body, and its symptoms can vary depending on the location and type of tumor. The grading and staging of this cancer are critical factors in determining the prognosis and treatment plan for affected children.
References:
[2] DOID:3521; Synonyms: pediatric sarcoma of the soft tissue [8] Seven and one tenth percent of STS arose in children and adolescents (age 0–19 years), while 78% of the cases were in adults (age 20–69 years)
Additional Characteristics
- Primarily affects children and adolescents
- Treatment options include surgery, chemotherapy, and radiation therapy
- Obsolete childhood soft tissue sarcoma
- Rare and aggressive type of cancer that affects children
- Characterized by growth of abnormal cells in soft tissues of body
- Variety of symptoms including lump or swelling, pain, weakness, weight loss
- Grading and staging critical factors in determining prognosis and treatment plan
Signs and Symptoms
Common Signs and Symptoms of Childhood Soft Tissue Sarcoma
Childhood soft tissue sarcoma, a rare type of cancer, can manifest in various ways. While symptoms may vary from child to child and disease to disease, there are some common signs that parents and caregivers should be aware of.
- Painless or Painful Swelling/Lump: The first symptom of a soft tissue sarcoma is often a painless mass or lump in an arm or leg, the trunk of the body, or other areas. This lump may grow over time (weeks to months) [10].
- Pain or Weakness: As the tumor compresses nerves or muscles, it can cause pain or weakness in the affected area [14].
- Limping: If the tumor is located on the leg or foot, it can lead to a limp [14].
Incidental Findings
In some cases, soft tissue sarcoma may be discovered incidentally during imaging tests for unrelated reasons. These findings are often asymptomatic and may not necessarily indicate cancer.
- Cholestasis: Some patients may present with signs or symptoms of cholestasis, including jaundice, dark urine, and pale stools [1
Diagnostic Tests
Diagnostic Tests for Childhood Soft Tissue Sarcoma
Childhood soft tissue sarcoma, a rare type of cancer that affects the soft tissues in children and adolescents, requires prompt diagnosis to ensure effective treatment. The diagnostic tests used to diagnose this condition have evolved over time, with some becoming obsolete due to advancements in medical technology.
Obsolete Diagnostic Tests:
- Needle Biopsy: While still used in some cases, needle biopsy is considered an outdated method for diagnosing soft tissue sarcoma (see [7]). Modern diagnostic techniques, such as imaging tests and excisional biopsies, have become more prevalent.
- Incisional Biopsy: Incisional biopsy, where a small portion of the tumor is removed for examination, has largely been replaced by more accurate methods like excisional biopsy (see [7]).
Current Diagnostic Tests:
- Imaging Tests: Magnetic Resonance Imaging (MRI) and Computed Tomography (CT) scans are commonly used to diagnose soft tissue sarcoma. These tests provide detailed images of the tumor, helping doctors determine its size, location, and potential spread.
- Biopsy: A biopsy is still considered the gold standard for diagnosing soft tissue sarcoma. Excisional biopsy, where the entire tumor is removed, is often preferred over incisional or needle biopsies due to its higher accuracy (see [7]).
- Physical Exam and Health History: A thorough physical examination and health history are essential in identifying potential signs of soft tissue sarcoma.
References:
[1] The rarity of soft tissue sarcoma, its heterogeneity, and overlap of symptoms with benign conditions are chal-lenges to timely diagnosis. (Source: [15]) [2] Adequate tissue should be submitted for conventional light microscopy before tissue has been taken for cytogenetics, electron microscopy, or other specialized studies. (Source: [6]) [3] Magnetic resonance imaging is the investigation of choice due to multiplanar imaging and better tissue discrimination. Final diagnosis is by histopathological examination. (Source: [8])
Treatment
Treatment Options for Obsolete Childhood Soft Tissue Sarcoma
Childhood soft tissue sarcomas are rare and aggressive tumors that can be challenging to treat. While treatment options have evolved over the years, some older treatments may still be relevant for certain cases.
- Anthracycline-based chemotherapy: This was a common first-line therapy for advanced or metastatic STS in children (Search Result 3). Anthracyclines, such as doxorubicin and epirubicin, have been used to treat various types of sarcomas, including soft tissue sarcoma.
- Gemcitabine-based chemotherapy: This has also been used as a first-line therapy for unresectable soft-tissue sarcoma in children (Search Result 6). Gemcitabine is an antimetabolite that works by inhibiting DNA synthesis and function.
- Trabectedin: This is a chemotherapeutic agent that has been approved for use after conventional upfront treatment (Search Result 4). Trabectedin has shown efficacy in treating soft tissue sarcomas, particularly in patients who have received prior chemotherapy.
Other Treatment Options
While these older treatments may still be relevant for certain cases, it's essential to note that modern treatment approaches often involve a combination of surgery, radiation therapy, and targeted therapy. For example:
- Surgery: This is often the primary treatment for localized soft tissue sarcomas (Search Result 13).
- Radiation therapy: This can be used in conjunction with surgery or as a standalone treatment for unresectable tumors.
- Targeted therapy: This involves using
Recommended Medications
- Targeted therapy
- Surgery
- Radiation therapy
- Anthracycline-based chemotherapy
- Gemcitabine-based chemotherapy
- trabectedin
💊 Drug information is sourced from ChEBI (Chemical Entities of Biological Interest) database. Always consult with a healthcare professional before starting any medication. Click on any medication name for detailed information.
Differential Diagnosis
Understanding Differential Diagnosis in Soft Tissue Sarcomas
Differential diagnosis refers to the process of distinguishing one medical condition from another based on their unique characteristics and symptoms. In the context of soft tissue sarcomas, differential diagnosis is crucial for identifying the correct type of cancer and determining the most effective treatment plan.
Common Differential Diagnoses in Childhood Soft Tissue Sarcoma
According to recent studies [3][4], rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in children, accounting for approximately 50% of cases. However, other types of soft tissue sarcomas, such as non-rhabdomyosarcomatous soft tissue sarcomas (NRSTS), must also be considered in the differential diagnosis.
- Alveolar Rhabdomyosarcoma: This is a rare and aggressive form of RMS that can mimic other small round cell neoplasms [6].
- Malignant Fibrous Histiocytoma (Undifferentiated Pleomorphic Sarcoma): This type of cancer can be challenging to distinguish from soft tissue sarcomas, particularly in children [8].
Importance of Accurate Differential Diagnosis
Accurate differential diagnosis is essential for providing the best possible care for children with soft tissue sarcomas. By identifying the correct type of cancer, healthcare providers can develop a tailored treatment plan that takes into account the unique characteristics and needs of each child.
- Improved Treatment Outcomes: Accurate differential diagnosis can lead to improved treatment outcomes, as the most effective therapies can be targeted at the specific type of cancer.
- Enhanced Patient Care: By providing accurate diagnoses and personalized treatment plans, healthcare providers can enhance patient care and improve overall quality of life for children with soft tissue sarcomas.
References
[3] Oct 15, 2024 — Rhabdomyosarcoma, a tumor of striated muscle, is the most common soft tissue sarcoma in children. It accounts for 50% of the soft tissue ...
[4] Oct 24, 2022 — Rhabdomyosarcoma, a tumor of striated muscle, is the most common soft tissue sarcoma in children aged 0 to 14 years and accounts for approximately 50% of ...
[6] The differential diagnosis includes all small round cell neoplasms but, most importantly, alveolar rhabdomyosarcoma.
[8] Soft tissue sarcomas in children are relatively rare. Approximately 850 to 900 children and adolescents are diagnosed each year with rhabdomyosarcoma (RMS) or one of the non-RMS soft tissue sarcomas (NRSTS).
Additional Information
- oboInOwl#hasOBONamespace
- disease_ontology
- oboInOwl#id
- DOID:3521
- core#notation
- DOID:3521
- IAO_0000115
- A sarcoma that affects children and is located_in the soft tissues of the body.
- rdf-schema#label
- obsolete childhood soft tissue sarcoma
- oboInOwl#hasExactSynonym
- pediatric sarcoma of the soft tissue
- owl#deprecated
- true
- 22-rdf-syntax-ns#type
- http://www.w3.org/2002/07/owl#Class
- rdf-schema#domain
- https://w3id.org/def/predibionto#has_symptom_10371
- owl#annotatedSource
- t428159
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