Discuss This Drug

trabectedin

CHEBI:CHEBI_84050

Definition

A tetrahydroisoquinoline alkaloid obtained from a Caribbean tunicate Ecteinascidia turbinata. Used for the treatment of soft tissue sarcoma and relapsed ovarian cancer.

Chemical Information

Molecular Formula
C39H43N3O11S
Molecular Mass
761.83700
Charge
0
SMILES
COc1cc2c(CCN[C@]22CS[C@H]3[C@H]4[C@@H]5N(C)[C@@H](Cc6cc(C)c(OC)c(O)c56)[C@H](O)N4[C@@H](COC2=O)c2c4OCOc4c(C)c(OC(C)=O)c32)cc1O
InChI
InChI=1S/C39H43N3O11S/c1-16-9-20-10-22-37(46)42-23-13-50-38(47)39(21-12-25(48-5)24(44)11-19(21)7-8-40-39)14-54-36(30(42)29(41(22)4)26(20)31(45)32(16)49-6)28-27(23)35-34(51-15-52-35)17(2)33(28)53-18(3)43/h9,11-12,22-23,29-30,36-37,40,44-46H,7-8,10,13-15H2,1-6H3/t22-,23-,29+,30+,36+,37-,39+/m0/s1
InChIKey
PKVRCIRHQMSYJX-AIFWHQITSA-N

Alternative Names

  • Ect 743
  • Ecteinascidin
  • Ecteinascidin 743
  • ET-743
  • ET743
  • trabectedin
  • Yondelis
  • (6R,6aR,7R,13S,14S,16R,20R)-6',8,14-trihydroxy-7',9-dimethoxy-4,10,23-trimethyl-19-oxo-3',4',6,7,12,13,14,16-octahydro-2'H,6aH-spiro[7,13-epimino-6,16-(epithiopropanooxymethano)[1,3]dioxolo[7,8]isoquinolino[3,2-b][3]benzazocine-20,1'-isoquinolin]-5-yl acetate

Treatment Applications

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

core#notation
CHEBI:84050
DRON_00010000
1716278
oboInOwl#hasDbXref
Wikipedia:Trabectedin

Additional References

Wikipedia:Trabectedin

🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.

Additional Attributes

core#notation
CHEBI:84050
rxcui
1718594
active_ingredient_strength
1 kg/kg
pharm_class_moa
Alkylating Activity [MoA]
pharm_class
Alkylating Drug [EPC]
pharm_class_epc
Alkylating Drug [EPC]
nui
N0000175558
package_marketing_start_date
25-AUG-21
manufacturer_name
Janssen Products, LP
active_ingredient_name
TRABECTEDIN
package_description
50 kg in 1 DRUM (42973-310-00)
unii
ID0YZQ2TCP
spl_set_id
472bd78e-be17-4b9d-90f4-9482c3aec9ff
22-rdf-syntax-ns#type
http://www.w3.org/2002/07/owl#Class
oboInOwl#hasOBONamespace
chebi_ontology
DRON_00010000
1716278
oboInOwl#hasDbXref
Wikipedia:Trabectedin
oboInOwl#id
CHEBI:84050
product_type
BULK INGREDIENT
marketing_category
BULK INGREDIENT
listing_expiration_date
20241231
dosage_form
INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION
route
INTRAVENOUS
marketing_start_date
20151023
labeler_name
Janssen Products, LP
generic_name
Trabectedin
product_ndc
70225-1110
spl_id
5e5c03ea-fc8a-4a14-9dc4-d78c9b54dc38
package_ndc
70225-1110-8
brand_name
YONDELIS
brand_name_base
YONDELIS
application_number
NDA207953
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_22333
oboInOwl#inSubset
http://purl.obolibrary.org/obo/chebi#3_STAR
has_treatment
http://purl.obolibrary.org/obo/DOID_4548
rdf-schema#range
https://w3id.org/def/predibionto#has_drug_113092
rdf-schema#domain
https://w3id.org/def/predibionto#has_side_effect36609
owl#annotatedSource
t307591
owl#someValuesFrom
t2990712