nodular basal cell carcinoma

Nodular Basal Cell Carcinoma: A Common Type of Skin Cancer

Nodular basal cell carcinoma (BCC) is the most common subtype of basal cell carcinoma, accounting for approximately 75% of all lesions [4]. It typically presents as a well-defined, pearly, translucent tumor with a rolled border that becomes more evident when the skin is stretched [4].

Characteristics:

• A small, shiny, firm, almost clear to pink in color, raised growth [8]
• May appear as a round, pearly bump on the skin [9]
• Can be red if intact [10]

Appearance:

• Nodular BCC often looks like a small, rounded nodule or bump on the skin
• The surface of the nodule may be smooth and shiny
• The color can range from almost clear to pink

Growth Pattern:

• Nodular BCC is a slow-growing tumor [13]
• It can continue to grow over time if left untreated

It's essential to note that nodular basal cell carcinoma is a type of skin cancer, and early detection and treatment are crucial to prevent further growth and potential complications. If you suspect you have a nodule or bump on your skin, it's always best to consult with a healthcare professional for proper evaluation and diagnosis.

Warning Signs and Symptoms of Nodular Basal Cell Carcinoma

Nodular basal cell carcinoma (BCC) is a type of skin cancer that can show up on the skin in many ways. Here are some common warning signs and symptoms to look out for:

• A small, pearly bump: Nodular BCC often presents as a small, shiny, and dome-shaped nodule that may be pink or translucent in color [8][9].
• A scaly patch of skin: A red or scaly patch of skin that may or may not be itchy or painful can also be a sign of nodular BCC [7].
• An open sore that doesn't heal: An open sore that does not heal, and may bleed, ooze or crust, is another warning sign of nodular BCC [11].
• A lump that looks like a pimple: A small, hard and waxy skin growth that resembles a pimple can also be a sign of nodular BCC [9].

It's essential

Treatment Options for Nodular Basal Cell Carcinoma

Nodular basal cell carcinoma (BCC) is a type of skin cancer that can be treated with various methods, including drug treatment. According to the search results, targeted drug therapy is one of the additional treatment options available for nodular BCC when it has spread or metastasized [1].

Cemiplimab: A Targeted Drug Treatment

One specific targeted drug treatment for advanced basal cell carcinoma (BCC) previously treated with a hedgehog pathway inhibitor (HHI) is Cemiplimab. This medication targets specific weaknesses present within cancer cells, making it an effective option for treating nodular BCC [2].

Other Treatment Options

While drug treatment is available for nodular BCC, surgery remains the main treatment modality in nearly all cases of BCC, including nodular type [6]. Other physical treatments recommended for BCC include curettage and cautery, cryosurgery, carbon dioxide laser, photodynamic therapy (PDT), and radiotherapy [8].

Key Points

• Targeted drug therapy is an additional treatment option for nodular BCC when it has spread or metastasized.
• Cemiplimab is a targeted drug treatment available for advanced basal cell carcinoma previously treated with a hedgehog pathway inhibitor.
• Surgery remains the main treatment modality for nodular BCC, but other physical treatments are also recommended.

References: [1] - Context result 1 [2] - Context result 2 [6] - Context result 6 [8] - Context result 8

Differential Diagnosis of Nodular Basal Cell Carcinoma

Nodular basal cell carcinoma (BCC) can be challenging to diagnose, as it shares similar characteristics with other skin lesions. The differential diagnosis for nodular BCC includes:

• Intradermal nevus: A benign melanocytic lesion that can mimic the appearance of nodular BCC [1].
• Sebaceous hyperplasia: A benign growth that can appear as a small, shiny nodule on the skin, similar to nodular BCC [2].
• Fibrous papule: A rare, benign tumor that can appear as a small, smooth nodule on the face, which may be confused with nodular BCC [3].

Key Features for Differential Diagnosis

To differentiate nodular BCC from these lesions, clinicians should look for the following features:

• Pigment flecks around the base of the nodule: In nodular BCC, pigment flecks are typically present at the base of the lesion, whereas in melanoma, they are not [4].
• Vascular patterns: The presence or absence of vascular patterns can help differentiate nodular BCC from other lesions. For example, intradermal nevi often exhibit a characteristic "vascular blush" [5].

Other Considerations

It's also essential to consider the following when differentiating nodular BCC:

• Clinical variant: Nodular BCC is more common in sun-exposed areas and can appear as a shiny or pearly nodule with a smooth surface [6].
• Dermoscopy: Dermoscopy can aid in the diagnosis of nodular BCC by highlighting characteristic features such as pigment flecks and vascular patterns [7].

References

[1] Context 2 [2] Context 3 [3] Context 4 [4] Context 5 [5] Context 11 [6] Context 7 [7] Context 9