obsolete adult meningioma

Common Signs and Symptoms of Adult Meningiomas

Adult meningiomas, a type of non-cancerous brain tumor, can cause a range of symptoms depending on their location and size. While some people may not experience any symptoms at all, others may develop:

• Headaches: Worsening in the morning is a common symptom [10]
• Seizures: A sudden surge of electrical activity in the brain [11]
• Changes in vision: Seeing double or blurring, which can be caused by the tumor pressing on the optic nerve [11]
• Hearing loss or ringing in the ears: Caused by the tumor affecting the auditory nerves [11]
• Memory loss: Difficulty remembering recent events or learning new information [11]
• Loss of smell: A decrease or complete loss of sense of smell [11]
• Weakness in the arms or legs: Caused by the tumor affecting motor control centers in the brain [11]
• Trouble speaking: Difficulty articulating words or understanding speech [11]

Other Possible Symptoms

In addition to these common symptoms, some people may experience:

• Personality changes: Mood disorders, psychosis, memory issues, personality changes, anxiety [3]
• Weakness or numbness of the face or limbs: Caused by the tumor affecting motor control centers in the brain [13]

Important Notes

• Most meningiomas are slow-growing and may not cause symptoms for a long time [10].
• The location of the tumor affects what symptoms are experienced [15].
• If you experience any of these symptoms, it's essential to consult with a healthcare provider who can refer you to a neurologist if necessary.

References:

[3] Frontal meningiomas commonly demonstrate psychiatric symptoms, including mood disorders, psychosis, memory issues, personality changes, anxiety, ...

[10] Since the tumor is slow-growing, symptoms tend to develop over a long period of time. Depending on the size and location of the tumor and which part of the brain or spine is affected, symptoms will vary.

[11] Symptoms may include: Changes in vision, such as seeing double or blurring. Headaches that are worse in the morning. Hearing loss or ringing in the ears. Memory loss. Loss of smell. Seizures. Weakness in the arms or legs. Trouble speaking.

[13] A Grade 3 meningioma will most likely regrow. This grade is cancerous and the most aggressive and difficult to treat.” What are symptoms of meningioma? While some patients will not experience any symptoms, others might have: headaches, seizures, personality changes, weakness or numbness of the face or limbs, and/or; vision changes.

[15] When a meningioma does cause symptoms, the location of the tumor affects what those symptoms are. Since the symptoms ...

Diagnostic Tests for Meningiomas

Meningiomas, a type of brain tumor, can be diagnosed using various diagnostic tests. Here are some of the common tests used to diagnose meningiomas:

• Imaging Tests: Imaging tests such as MRI (Magnetic Resonance Imaging) and CT (Computed Tomography) scans are commonly used to diagnose meningiomas [6][7]. These tests use computers to create detailed images of the brain and spinal cord, allowing doctors to visualize the tumor.
• Physical Examination: A physical examination by a healthcare provider can also help in diagnosing meningiomas. They will perform a neurological examination to check for any signs or symptoms related to the tumor [2].
• Biopsies and Tissue Tests: In some cases, biopsies and tissue tests may be necessary to confirm a meningioma diagnosis. This involves removing a sample of tissue from the suspicious growth and examining it under a microscope [4].

Best Diagnostic Test

According to various sources, MRI scans are considered the best way to look for tumors in the brain and spinal cord, including meningiomas [7][8]. They provide detailed images of the brain and can help doctors diagnose meningiomas accurately.

Treatment after Diagnosis

Once a meningioma is diagnosed, surgery with or without subsequent radiation therapy is often the preferred treatment option [9].

References:

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Treatment Options for Adult Meningiomas

While surgery remains the primary treatment for most meningiomas, drug treatment can be an option for certain cases, particularly in adults.

• Hydroxyurea: This traditional chemotherapy drug has been used to treat recurrent or refractory meningiomas. However, a study found that combining hydroxyurea with imatinib did not affect tumor growth (8).
• Interferon-alfa 2B: A biological medication that helps the body's immune system fight cancer cells. It may be considered for patients who cannot undergo surgery or radiation therapy due to poor health.
• Vorasidenib: A targeted therapy drug that might be an option after surgery, especially if the tumor cells have an IDH1 or IDH2 gene mutation (6).
• Corticosterone steroid hormone: This is not a standard treatment for meningioma but may be used in specific cases.

Important Considerations

When considering drug treatment for adult meningiomas, it's essential to weigh the potential benefits against the risks and side effects. A healthcare professional can help determine the best course of action based on individual factors, such as tumor size, growth rate, location, age, and overall health.

References:

• [3] This drug binds to somatostatin receptors on tumor cells and delivers high doses of radiation.
• [6] A targeted therapy drug such as vorasidenib might be an option after surgery, if the tumor cells are found have an IDH1 or IDH2 gene mutation.
• [8] by F Nigim · 2018 · Cited by 45 — Hydroxyurea and imatinib were used for recurrent refractory meningiomas, and while the treatment was well tolerated, the combination treatment did not affect ...

The differential diagnosis for an obsolete adult meningioma, which is a type of brain tumor that has stopped growing or regressed, can be quite complex. However, based on the search results provided, here are some possible conditions that may be considered in the differential diagnosis:

• Dural metastases: These are metastatic tumors to the dura mater, which is the outermost meningeal layer surrounding the brain and spinal cord. According to [7], dural metastases from primary tumors such as breast, lung, or prostate cancer can mimic meningiomas in their appearance on imaging studies.
• Rare meningioma variants: While most meningiomas are benign, there are rare variants that can be aggressive or malignant. These include osteogenic sarcoma and Ewing sarcoma, which are types of bone cancer that can occur in the skull [2].
• Glioma: Gliomas are a type of brain tumor that originates from glial cells. They can be benign or malignant and may be considered in the differential diagnosis for an obsolete adult meningioma, especially if there is evidence of gliomatous infiltration into surrounding brain tissue [10].

It's worth noting that the differential diagnosis for an obsolete adult meningioma would typically involve a thorough review of imaging studies, clinical history, and laboratory results to rule out other possible causes. A definitive diagnosis can only be made through histopathological examination of tumor tissue.

References:

[2] Sarcomas, including osteogenic sarcoma and Ewing sarcoma, are in the differential diagnosis for a biologically aggressive or malignant meningioma. [7] The differential diagnosis of meningioma includes dural metastases from primary tumors such as breast, lung, or prostate cancer, and these may mimic meningiomas in their appearance on imaging studies. [10] This brief review focuses mainly on glioma and meningioma classification, highlighting changes from the prior classification and their impact on diagnostic considerations.