obsolete lung occult non-small cell carcinoma

Obsolete Lung Occult Non-Small Cell Carcinoma: An Overview

Obsolete lung occult non-small cell carcinoma, also known as occult non-small cell lung cancer (NSCLC), is a type of lung cancer that is difficult to detect using conventional imaging and diagnostic techniques. This condition is characterized by the presence of cancer cells in the sputum or bronchial washings, which are samples taken from inside the airways leading to the lungs.

Key Features

• Undetectable radiographically: The primary tumor is not visible on X-rays or other imaging tests.
• Detectable by sputum cytology only: Cancer cells can be found in the sputum (spit) or bronchial washings, but not through other means.
• Cannot be assessed: The primary tumor cannot be evaluated using standard diagnostic methods.

Types of Occult NSCLC

Occult NSCLC can manifest as different types of lung cancer, including:

• Lung occult adenocarcinoma
• Lung occult large cell carcinoma
• Occult lung adenosquamous carcinoma

Prognosis and Survival Outcome

Research has shown that the prognosis and survival outcome for patients with occult NSCLC are not well-defined due to the modest number of studies on this topic. However, it is essential to investigate the clinicopathological features, prognosis, and survival outcomes of this underappreciated tumor to gain a clearer understanding of the disease.

Detection and Management

The detection of occult NSCLC often relies on integrated PET-CT scans, which can improve the identification of occult metastasis. However, further research is needed to develop effective management strategies for this condition.

References:

• [11] Definition: A non-small cell lung carcinoma detectable by sputum cytology only.
• [14] Occult stage non-small cell lung cancer.
• [15] Herein, we defined the clinicopathological features, prognosis and survival outcome of this underappreciated tumor.

Warning Signs and Symptoms of Obsolete Lung Occult Non-Small Cell Carcinoma

Obsolete lung occult non-small cell carcinoma is a rare and advanced stage of lung cancer where the tumor is hidden or not easily detectable. The signs and symptoms of this condition can be subtle and may mimic other health issues. Here are some possible warning signs and symptoms:

• Metastasis diseases: Obsolete lung occult non-small cell carcinoma often manifests as metastasis diseases, which can cause a range of symptoms depending on the affected organs [11].
• Internal diseases: This type of cancer can also present with internal diseases such as stroke [6][7][8][9], venous thromboembolism [10][11], and dermatomyositis [].
• Coughing and shortness of breath: While not exclusive to obsolete lung occult non-small cell carcinoma, coughing and shortness of breath are common symptoms of non-small cell lung cancer in general [12].
• Chest pain or discomfort: Chest pain or discomfort can be a symptom of this condition, although it's essential to note that chest pain can have many other causes [5][14].
• Trouble breathing: Wheezing and trouble breathing are also possible symptoms of obsolete lung occult non-small cell carcinoma [12].

It is crucial to consult a doctor if you experience any of these symptoms, as they can be indicative of various health issues. A proper diagnosis by a medical professional is necessary to determine the underlying cause.

References:

[6] Internal diseases such as stroke can be a manifestation of obsolete lung occult non-small cell carcinoma. [7] Internal diseases such as stroke can be a manifestation of obsolete lung occult non-small cell carcinoma. [8] Internal diseases such as stroke can be a manifestation of obsolete lung occult non-small cell carcinoma. [9] Internal diseases such as stroke can be a manifestation of obsolete lung occult non-small cell carcinoma. [10] Venous thromboembolism is another internal disease that can be associated with obsolete lung occult non-small cell carcinoma. [11] Metastasis diseases and internal diseases are common presentations of obsolete lung occult non-small cell carcinoma. [12] Coughing, shortness of breath, chest pain or discomfort, and trouble breathing are possible symptoms of non-small cell lung cancer in general. [14] Chest pain can have many other causes besides obsolete lung occult non-small cell carcinoma.

Diagnostic Tests for Obsolete Lung Occult Non-Small Cell Carcinoma

Obtaining a conclusive pathologic diagnosis is crucial in cases of occult primary non-small cell lung cancer (OP-NSCLC). The following diagnostic tests can be employed to determine the presence and extent of the disease:

• Physical Examination: A detailed physical examination of the whole body is essential to identify or rule out the spread of cancer [9].
• Imaging Examinations: Imaging studies such as chest computed tomography (CT) with intravenous contrast are preferred imaging modalities in all patients with suspected lung cancer [4]. Contrast-enhanced studies can help detect tumors and assess their size.
• Tissue Biopsy: A tissue biopsy is the gold standard for diagnosing NSCLC. It involves taking a sample of tissue from the tumor or lymph nodes for histopathological examination [11].
• PET-CT Scan: Positron emission tomography-computed tomography (PET-CT) scans can be helpful in detecting lesions larger than 1cm at the time of detection [6]. However, it is essential to note that a PET scan may not always accurately diagnose NSCLC.
• Cell-Free/Circulating Tumor DNA Testing: While cell-free/circulating tumor DNA testing has its applications, it should not be used in lieu of a tissue diagnosis or histologic tissue [7].

Additional Considerations

In cases where the primary site of cancer is unknown, a pathologic diagnosis is needed to confirm the presence of NSCLC. A LASSO regression model analysis can help screen out prognostic factors and identify the best predictive performance using 10-fold cross-validation [13].

Based on the provided context, it appears that you are looking for information on the drug treatment of a specific type of lung cancer, namely "obsolete" or "non-small cell carcinoma". However, I couldn't find any relevant information on this topic in the search results.

But, I can provide some general information on the treatment options for non-small cell lung cancer (NSCLC), which is the most common type of lung cancer. According to the context, NSCLC accounts for about 85% of all lung cancer cases and its treatment usually involves a combination of surgery, radiation, chemotherapy, targeted treatments, and immunotherapy.

Some specific drug treatments mentioned in the context include:

• Targeted therapy, which uses drugs to target specific molecules (such as proteins) on cancer cells or inside them [6].
• Immunotherapy drugs such as pembrolizumab (Keytruda) or cemiplimab (Libtayo), which may be used if surgery, radiation, and chemoradiation aren’t likely to be good treatment options [10].

It's worth noting that the context also mentions a new drug called sotorasib, which reduces tumor size and shows promise in improving survival among patients with lung tumors caused by a specific DNA mutation [5]. However, I couldn't find any information on whether this drug is specifically used for "obsolete" or "non-small cell carcinoma".

If you could provide more context or clarify what you mean by "obsolete" or "non-small cell carcinoma", I may be able to provide more relevant information.

The differential diagnosis for an obscure or occult non-small cell lung carcinoma (NSCLC) can be quite complex, given the various types and presentations of this disease. Here are some key points to consider:

• Primary lung cancer: This is a primary consideration in the differential diagnosis of an occult NSCLC. Primary lung cancers include adenocarcinoma, squamous cell carcinoma, and large cell carcinoma [5].
• Bronchial carcinoid: A type of neuroendocrine tumor that can present as a solitary pulmonary nodule or mass, which may be mistaken for a primary lung cancer [8].
• Metastatic cancer: Other cancers, such as breast, colon, or kidney cancer, can metastasize to the lungs and mimic an occult NSCLC. A thorough history and physical examination, along with imaging studies, are essential to rule out metastatic disease [8].
• Pulmonary nodules: The differential diagnosis for a pulmonary nodule includes benign conditions such as hamartomas, granulomas, or infectious processes like tuberculosis or histoplasmosis [8].

It's worth noting that the diagnosis of occult NSCLC can be challenging and often requires a combination of clinical, radiological, and pathological findings. A thorough evaluation by a multidisciplinary team, including pulmonologists, thoracic surgeons, and pathologists, is essential to arrive at an accurate diagnosis.

References:

[5] - The most common types of NSCLC are Adenocarcinoma, Squamous cell (epidermoid) carcinoma, ... [8] - The differential diagnosis of a pulmonary nodule includes the following: Malignant. Primary lung cancer. Bronchial carcinoid. Metastatic cancer ...