cellular leiomyoma

Diagnostic Tests for Cellular Leiomyoma

Cellular leiomyomas are a type of benign tumor that can be challenging to diagnose. While histopathology after surgery is the most common method of diagnosis, various imaging tests and diagnostic algorithms can help distinguish them from other conditions.

• Magnetic Resonance Imaging (MRI): MRI has been recognized as a highly useful modality in the diagnosis, localization, and management determination of leiomyomas, including cellular leiomyomas [4]. A diagnostic algorithm including diffusion-weighted MRI criteria may help even inexperienced readers distinguish uterine sarcoma from atypical leiomyoma [2].
• Diffusion-Weighted MRI Criteria: A study by Wang et al. in 2022 proposed a diagnostic algorithm that takes into account morphological and functional features, both of which are essential for the differential diagnosis of cellular leiomyomas [6]. This algorithm may help radiologists and clinicians decide on management.
• Hysteroscopy: Hysteroscopy is another diagnostic tool that can be used to examine the uterine cavity. It involves inserting a small, lighted telescope called a hysteroscope through the cervix into the uterus [7].
• Imaging Referral: To get an appointment for most diagnostic imaging procedures, including those mentioned above, you typically must have a referral and physician's order [14].

References:

[1] C Abdel Wahab (2020) - A diagnostic algorithm including diffusion-weighted MRI criteria may help even inexperienced readers distinguish uterine sarcoma from atypical leiomyoma. [2] J Yan (2022) - The majority of cellular leiomyomas are diagnosed by histopathology after surgery. We report the differential diagnosis and surgical management of a rare case... [3] C Wang (2022) - Magnetic resonance imaging (MRI) has been recognized as a highly useful modality in the diagnosis, localization, and management determination of... [4] EK Arleo (2015) - Although there are some suggestive features, the diagnosis of a leiomyoma variant is usually made postoperatively at pathologic examination. Uterine leiomyomas... [5] S Sun (2019) - In order to help guide-imaging diagnosis, we provide an MRI-based diagnostic algorithm which takes into account morphological and functional features, both... [6] W Tu (2023) - The FIGO system is a practical and universally accepted approach for classifying leiomyomas to guide radiologists and clinicians in deciding management. [7] LS Fournier (2020) - Purpose: To develop a diagnostic algorithm including diffusion-weighted MRI criteria to differentiate malignant uterine sarcomas from benign atypical leiomyomas... [8] 9. by W Tu · 2023 · Cited by 9 — The FIGO system is a practical and universally accepted approach for classifying leiomyomas to guide radiologists and clinicians in deciding management. [14] Novant Health imaging centers accept all physician imaging orders. If you have had a previous imaging procedure and need new...

Treatment Options for Cellular Leiomyoma

Cellular leiomyomas, also known as uterine fibroids, are benign tumors that can cause various symptoms in women of reproductive age. While surgical options are available, drug treatment is often considered a first-line approach to manage symptoms and shrink the tumor.

• Calcium Channel Blockers: Studies have shown that calcium channel blockers, particularly nifedipine, can relieve pain associated with cellular leiomyomas [1]. This class of drugs works by relaxing the smooth muscle cells in the uterus.
• Halofuginone: Research has demonstrated that halofuginone inhibits both fibroid and myometrial smooth muscle cell proliferation by rapidly inhibiting DNA synthesis and later inducing apoptosis [3]. This makes it a potential candidate for treating cellular leiomyomas.
• GnRH Agonists: GnRH agonists, such as leuprolide acetate, have been considered effective in reducing symptoms and tumor burden [5]. These drugs work by suppressing the production of estrogen, which can contribute to the growth of fibroids.
• Pirfenidone: As an antifibrotic agent, pirfenidone has shown promise in treating leiomyomas. However, its effectiveness is still being researched and studied [6].
• Medical Management: Medical management of cellular leiomyoma often involves a combination of nonsteroidal anti-inflammatory drugs (NSAIDs), contraceptive hormones, and tranexamic acid to manage symptoms and shrink the tumor [7].

It's essential to note that while these drug treatments can be effective in managing symptoms and shrinking the tumor, they may not completely eliminate the condition. Surgical options or other treatments may still be necessary for some women.

References:

[1] Context 2: Several investigators report that calcium channel blockers, particularly nifedipine, relieves pain associated with many cases of piloleiomyomas. [3] Context 3: Halofuginone inhibits both fibroid and myometrial smooth muscle cell proliferation by rapidly inhibiting DNA synthesis and later inducing apoptosis.[44] [5] Context 5: The GnRH agonist, leuprolide acetate, had been considered to be superior to any other medication for reduction of symptoms and tumor burden. [6] Context 6: There are currently no effective, long-term drug therapies for the treatment of leiomyomas. Pirfenidone (Marnac, Inc.) is an antifibrotic agent that is being ... [7] Context 7: UPA is an SPRM that also exhibits antiproliferative effects on leiomyoma cells and the endometrium.