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cefiderocol

CHEBI:CHEBI_140376

Definition

A fourth-generation siderophore cephalosporin antibiotic having {1-[2-(2-chloro-3,4-dihydroxybenzamido)ethyl]pyrrolidinium-1-yl}methyl and [(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-{[(2-carboxypropan-2-yl)oxy]imino}acetyl]amino side groups located at positions 3 and 7 respectively, developed to combat a variety of bacterial pathogens, including beta-lactam- and carbapenem-resistant organisms.

Chemical Information

Molecular Formula
C30H34ClN7O10S2
Molecular Mass
752.210
Charge
0
SMILES
[H][C@]12SCC(C[N+]3(CCNC(=O)C4=CC=C(O)C(O)=C4Cl)CCCC3)=C(N1C(=O)[C@H]2NC(=O)C(=N/OC(C)(C)C(O)=O)\C1=CSC(N)=N1)C([O-])=O
InChI
InChI=1S/C30H34ClN7O10S2/c1-30(2,28(46)47)48-36-19(16-13-50-29(32)34-16)24(42)35-20-25(43)37-21(27(44)45)14(12-49-26(20)37)11-38(8-3-4-9-38)10-7-33-23(41)15-5-6-17(39)22(40)18(15)31/h5-6,13,20,26H,3-4,7-12H2,1-2H3,(H7-,32,33,34,35,36,39,40,41,42,44,45,46,47)/t20-,26-/m1/s1
InChIKey
DBPPRLRVDVJOCL-FQRUVTKNSA-N

Alternative Names

  • cefiderocol
  • cefiderocolum
  • GSK 2696266
  • GSK-2696266
  • GSK2696266
  • RSC 649266
  • S 649266
  • S-649266
  • S649266
  • (6R,7R)-7-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-{[(2-carboxypropan-2-yl)oxy]imino}acetyl]amino}-3-({1-[2-(2-chloro-3,4-dihydroxybenzamido)ethyl]pyrrolidinium-1-yl}methyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

core#notation
CHEBI:140376
oboInOwl#hasDbXref
Wikipedia:Cefiderocol
DRON_00010000
2265702

Additional References

Wikipedia:Cefiderocol

🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.

Additional Attributes

core#notation
CHEBI:140376
oboInOwl#hasOBONamespace
chebi_ontology
oboInOwl#hasDbXref
Wikipedia:Cefiderocol
DRON_00010000
2265702
oboInOwl#id
CHEBI:140376
rxcui
2265711
product_type
BULK INGREDIENT
marketing_category
BULK INGREDIENT
listing_expiration_date
20251231
dosage_form
INJECTION, POWDER, FOR SOLUTION
pharm_class
Cephalosporins [CS]
route
INTRAVENOUS
marketing_start_date
20200131
package_marketing_start_date
31-JAN-20
active_ingredient_strength
1 g/10mL
generic_name
Cefiderocol sulfate tosylate
product_ndc
59630-266
labeler_name
Shionogi Inc.
spl_id
ec2ab26a-5b44-46d7-9f87-f6fdc65c7db1
active_ingredient_name
CEFIDEROCOL SULFATE TOSYLATE
package_ndc
59630-266-10
package_description
10 VIAL, SINGLE-USE in 1 CARTON (59630-266-10) / 10 mL in 1 VIAL, SINGLE-USE (59630-266-01)
brand_name
Fetroja
brand_name_base
Fetroja
application_number
NDA209445
manufacturer_name
Shionogi Inc.
unii
TTP8LBP45D
spl_set_id
75c0c785-38e0-4049-a6fb-b77581f5b35c
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_26672
oboInOwl#inSubset
http://purl.obolibrary.org/obo/chebi#3_STAR
22-rdf-syntax-ns#type
http://www.w3.org/2002/07/owl#Class
has_treatment
http://purl.obolibrary.org/obo/DOID_2567
rdf-schema#domain
https://w3id.org/def/predibionto#has_side_effect5198
owl#annotatedSource
t108896
owl#someValuesFrom
t3472757