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Leucovorin

CHEBI:CHEBI_15640

Definition

A formyltetrahydrofolic acid in which the formyl group is located at position 5.

Chemical Information

Molecular Formula
C20H23N7O7
Molecular Mass
473.43930
Charge
0
SMILES
[H]C(=O)N1C(CNc2ccc(cc2)C(=O)N[C@@H](CCC(O)=O)C(O)=O)CNc2nc(N)[nH]c(=O)c12
InChI
InChI=1S/C20H23N7O7/c21-20-25-16-15(18(32)26-20)27(9-28)12(8-23-16)7-22-11-3-1-10(2-4-11)17(31)24-13(19(33)34)5-6-14(29)30/h1-4,9,12-13,22H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,23,25,26,32)/t12?,13-/m0/s1
InChIKey
VVIAGPKUTFNRDU-ABLWVSNPSA-N

Alternative Names

  • (5-formyl-5,6,7,8-tetrahydropteroyl)glutamate
  • 10-Formyl-7,8-dihydrofolic acid
  • 5-Formyl-5,6,7,8-tetrahydrofolic acid
  • 5-Formyl-5,6,7,8-tetrahydropteroyl-L-glutamic acid
  • 5-Formyltetrahydrofolate
  • Acide folinique
  • folinate
  • Folinic acid
  • L(-)-5-Formyl-5,6,7,8-tetrahydrofolic acid
  • Leucovorin
  • Leucovorinum
  • N-(5-formyl-5,6,7,8-tetrahydropteroyl)-L-glutamic acid
  • N-[4-({[2-amino-5-formyl-4-oxo-3,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)benzoyl]-L-glutamic acid
  • N5-Formyl-5,6,7,8-tetrahydrofolic acid
  • N5-Formyltetrahydrofolic acid

Treatment Applications

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

core#notation
CHEBI:15640
DRON_00010000
6313
oboInOwl#hasDbXref
Wikipedia:Folinic_acid

Additional References

Wikipedia:Folinic_acid

🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.

Additional Attributes

product_type
BULK INGREDIENT
listing_expiration_date
20241231
dosage_form
INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION
marketing_category
BULK INGREDIENT FOR HUMAN PRESCRIPTION COMPOUNDING
labeler_name
Huzhou Zhanwang Pharmaceutical Co., Ltd.
marketing_start_date
19870914
spl_id
643fe92a-6df8-5b71-e053-2a91aa0a81c5
application_number
ANDA089384
product_ndc
70436-120
route
INTRAVENOUS
package_ndc
10695-001-17
package_description
500 g in 1 BOTTLE (10695-001-17)
core#notation
CHEBI:15640
rxcui
2104714
manufacturer_name
Slate Run Pharmaceuticals, LLC
active_ingredient_strength
350 mg/17.5mL
active_ingredient_name
LEVOLEUCOVORIN CALCIUM
pharm_class
Folic Acid [CS]
unii
RPR1R4C0P4
spl_set_id
46d12bd0-ec7d-4e2c-aeed-b8aa88e6dc5c
upc
0371205908300
package_marketing_start_date
02-FEB-18
22-rdf-syntax-ns#type
http://www.w3.org/2002/07/owl#Class
oboInOwl#hasOBONamespace
chebi_ontology
DRON_00010000
6313
oboInOwl#hasDbXref
Wikipedia:Folinic_acid
oboInOwl#hasAlternativeId
CHEBI:2057
oboInOwl#id
CHEBI:15640
generic_name
Leucovorin calcium
brand_name
Leucovorin calcium
brand_name_base
Leucovorin calcium
oboInOwl#inSubset
http://purl.obolibrary.org/obo/chebi#3_STAR
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_76971
chebi#is_conjugate_acid_of
http://purl.obolibrary.org/obo/CHEBI_65340
has_treatment
http://purl.obolibrary.org/obo/DOID_6703
rdf-schema#range
https://w3id.org/def/predibionto#has_drug_105728
chebi#is_conjugate_base_of
http://purl.obolibrary.org/obo/CHEBI_65340
owl#annotatedSource
t116126
owl#someValuesFrom
t3038425