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2-[4-(piperidin-3-yl)phenyl]-2H-indazole-7-carboxamide

CHEBI:CHEBI_177298

Definition

A member of the class of indazoles that is 2H-indazole substituted by 4-(piperidin-3-yl)phenyl and aminocarbonyl groups at positions 2 and 7, respectively. It is a potent PARP1 inhibitor with IC50 of 3.2 nM.

Chemical Information

Molecular Formula
C19H20N4O
Molecular Mass
320.396
Charge
0
SMILES
NC(=O)C1=CC=CC2=CN(N=C12)C1=CC=C(C=C1)C1CCCNC1
InChI
InChI=1S/C19H20N4O/c20-19(24)17-5-1-3-15-12-23(22-18(15)17)16-8-6-13(7-9-16)14-4-2-10-21-11-14/h1,3,5-9,12,14,21H,2,4,10-11H2,(H2,20,24)
InChIKey
PCHKPVIQAHNQLW-UHFFFAOYSA-N

Alternative Names

  • 2-[4-(piperidin-3-yl)phenyl]-2H-indazole-7-carboxamide

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

core#notation
CHEBI:177298
oboInOwl#hasDbXref
PMID:25761096

Additional References

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Additional Attributes

owl#annotatedSource
t137518
oboInOwl#hasOBONamespace
chebi_ontology
oboInOwl#id
CHEBI:177298
core#notation
CHEBI:177298
oboInOwl#hasDbXref
PMID:25761096
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_62913
oboInOwl#inSubset
http://purl.obolibrary.org/obo/chebi#3_STAR
22-rdf-syntax-ns#type
http://www.w3.org/2002/07/owl#Class