Discuss This Drug

niraparib

CHEBI:CHEBI_176844

Definition

A 2-[4-(piperidin-3-yl)phenyl]-2H-indazole-7-carboxamide that has S-configuration. It is a potent inhibitor of PARP1 and PARP2 (IC50 of 3.8 and 2.1 nM, respectively) and approved as a first-line maintenance treatment for women with advanced ovarian cancer after responding to platinum-based chemotherapy.

Chemical Information

Molecular Formula
C19H20N4O
Molecular Mass
320.396
Charge
0
SMILES
[H][C@]1(CCCNC1)C1=CC=C(C=C1)N1C=C2C=CC=C(C(N)=O)C2=N1
InChI
InChI=1S/C19H20N4O/c20-19(24)17-5-1-3-15-12-23(22-18(15)17)16-8-6-13(7-9-16)14-4-2-10-21-11-14/h1,3,5-9,12,14,21H,2,4,10-11H2,(H2,20,24)/t14-/m1/s1
InChIKey
PCHKPVIQAHNQLW-CQSZACIVSA-N

Alternative Names

  • 2-[4-(3S)-3-piperidinylphenyl]-2H-indazole-7-carboxamide
  • 2-[4-[(3S)-piperidin-3-yl]phenyl]indazole-7-carboxamide
  • 2-{4-[(3S)-piperidin-3-yl]phenyl}-2H-indazole-7-carboxamide
  • MK 4827
  • MK-4827
  • MK4827
  • niraparib
  • niraparibum
  • Zejula

Treatment Applications

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

oboInOwl#hasDbXref
Wikipedia:Niraparib
DRON_00010000
1918231
core#notation
CHEBI:176844

Additional References

Wikipedia:Niraparib

🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.

Additional Attributes

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chebi_ontology
oboInOwl#hasDbXref
Wikipedia:Niraparib
DRON_00010000
1918231
oboInOwl#id
CHEBI:176844
generic_name
Niraparib tosylate monohydrate
product_type
BULK INGREDIENT
marketing_category
BULK INGREDIENT
dosage_form
CAPSULE
labeler_name
Quotient Sciences - Philadelphia, LLC
product_ndc
11014-0573
brand_name
AKEEGA
brand_name_base
AKEEGA
application_number
NDA216793
oboInOwl#inSubset
http://purl.obolibrary.org/obo/chebi#3_STAR
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_68495
core#notation
CHEBI:176844
rxcui
2645253
listing_expiration_date
20241231
route
ORAL
active_ingredient_strength
1 kg/kg
pharm_class
Poly(ADP-Ribose) Polymerase Inhibitors [MoA]
marketing_start_date
20230426
active_ingredient_name
NIRAPARIB
unii
195Q483UZD
package_marketing_start_date
26-NOV-19
spl_id
ec811538-f660-b404-e053-2995a90a3fa4
package_ndc
11014-0573-1
package_description
1 BAG in 1 PAIL (11014-0573-1) / 14078 TABLET, FILM COATED in 1 BAG
manufacturer_name
Janssen Biotech, Inc.
spl_set_id
8245a990-3268-4613-b5c5-9537858a1eb9
22-rdf-syntax-ns#type
http://www.w3.org/2002/07/owl#Class
has_treatment
http://purl.obolibrary.org/obo/DOID_6213
owl#annotatedSource
t137187
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t3992491
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https://w3id.org/def/predibionto#has_drug_113145
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