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niraparib

CHEBI:CHEBI_176844

Definition

A 2-[4-(piperidin-3-yl)phenyl]-2H-indazole-7-carboxamide that has S-configuration. It is a potent inhibitor of PARP1 and PARP2 (IC50 of 3.8 and 2.1 nM, respectively) and approved as a first-line maintenance treatment for women with advanced ovarian cancer after responding to platinum-based chemotherapy.

Chemical Information

Molecular Formula
C19H20N4O
Molecular Mass
320.396
Charge
0
SMILES
[H][C@]1(CCCNC1)C1=CC=C(C=C1)N1C=C2C=CC=C(C(N)=O)C2=N1
InChI
InChI=1S/C19H20N4O/c20-19(24)17-5-1-3-15-12-23(22-18(15)17)16-8-6-13(7-9-16)14-4-2-10-21-11-14/h1,3,5-9,12,14,21H,2,4,10-11H2,(H2,20,24)/t14-/m1/s1
InChIKey
PCHKPVIQAHNQLW-CQSZACIVSA-N

Alternative Names

  • 2-[4-(3S)-3-piperidinylphenyl]-2H-indazole-7-carboxamide
  • 2-[4-[(3S)-piperidin-3-yl]phenyl]indazole-7-carboxamide
  • 2-{4-[(3S)-piperidin-3-yl]phenyl}-2H-indazole-7-carboxamide
  • MK 4827
  • MK-4827
  • MK4827
  • niraparib
  • niraparibum
  • Zejula

Treatment Applications

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

oboInOwl#hasDbXref
Wikipedia:Niraparib
DRON_00010000
1918231
core#notation
CHEBI:176844

Additional References

Wikipedia:Niraparib

🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.

Additional Attributes

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RO_0000087
http://purl.obolibrary.org/obo/CHEBI_68495
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