Discuss This Drug

polymyxin

CHEBI:CHEBI_59062

Definition

Polymyxins are antibiotics with a general structure consisting of a cyclic peptide with a long hydrophobic tail. They disrupt the structure of the bacterial cell membrane by interacting with its phospholipids. Polymyxins are produced by the Gram-positive bacterium Bacillus polymyxa and are selectively toxic for Gram-negative bacteria.

Alternative Names

  • polymixin
  • polymycin
  • polymyxins

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

core#notation
CHEBI:59062

🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.

Additional Attributes

oboInOwl#hasOBONamespace
chebi_ontology
oboInOwl#id
CHEBI:59062
generic_name
polymyxin b sulfate and trimethoprim sulfate
brand_name
polymyxin b sulfate and trimethoprim sulfate
brand_name_base
polymyxin b sulfate and trimethoprim sulfate
product_type
BULK INGREDIENT
marketing_category
BULK INGREDIENT FOR HUMAN PRESCRIPTION COMPOUNDING
dosage_form
INJECTION, POWDER, FOR SOLUTION
application_number
ANDA211572
product_ndc
70069-311
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_33282
oboInOwl#inSubset
http://purl.obolibrary.org/obo/chebi#3_STAR
listing_expiration_date
20241231
labeler_name
BIOTIKA a.s.
marketing_start_date
20120331
spl_id
80ad4adc-72c3-4398-a639-3d6a6ae9ec17
rxcui
1359350
manufacturer_name
Preferred Pharmacetucials Inc.
package_marketing_start_date
19980416
unii
E377MF8EQ8
package_description
10 mL in 1 BOTTLE, DROPPER (53002-8621-1)
active_ingredient_name
TRIMETHOPRIM SULFATE
core#notation
CHEBI:59062
nui
N0000187062
pharm_class_moa
Cytochrome P450 2C8 Inhibitors [MoA]
pharm_class
Dihydrofolate Reductase Inhibitor Antibacterial [EPC]
active_ingredient_strength
500000 [iU]/1
pharm_class_epc
Dihydrofolate Reductase Inhibitor Antibacterial [EPC]
spl_set_id
93d52a75-9a96-4f96-be41-9ccdcabc0933
upc
0370069311011
22-rdf-syntax-ns#type
http://www.w3.org/2002/07/owl#Class
route
INTRATHECAL
package_ndc
70069-311-01
has_treatment
http://purl.obolibrary.org/obo/DOID_14338
rdf-schema#domain
https://w3id.org/def/predibionto#has_side_effect22953
owl#annotatedSource
t252647