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colistimethate

CHEBI:CHEBI_59662

Definition

A mixture where R = H or Me. Colistin in which each of the primary amino groups is converted to the corresponding aminomethanesulfonic acid. It is prepared from colistin by the action of formaldehyde followed by sodium bisulfite. A polymyxin antibiotic, it is used as its penta-sodium salt in the treatment of severe infections, particularly of multidrug-resistant Gram-negative bacteria such as Pseudomonas aeruginosa and Acinetobacter baumannii.

Chemical Information

Molecular Formula
C57H107N16O28S5R
Molecular Mass
1624.883
Charge
0
SMILES
C(C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H]1C(N[C@H](C(N[C@@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(=O)NCC1)[C@@H](C)O)=O)CCNCS(O)(=O)=O)=O)CCNCS(O)(=O)=O)=O)CC(C)C)=O)CC(C)C)=O)CCNCS(O)(=O)=O)=O)=O)CCNCS(O)(=O)=O)=O)[C@@H](C)O)=O)CCNCS(O)(=O)=O)=O)CCC[C@@H](C*)C

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

oboInOwl#hasDbXref
DrugBank:DB01111
DRON_00010000
2708
core#notation
CHEBI:59662

Additional References

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Additional Attributes

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https://w3id.org/def/predibionto#has_side_effect29669
chebi#is_conjugate_base_of
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owl#annotatedSource
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oboInOwl#hasOBONamespace
chebi_ontology
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DRON_00010000
2708
oboInOwl#id
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core#notation
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chebi#has_functional_parent
http://purl.obolibrary.org/obo/CHEBI_37943
oboInOwl#inSubset
http://purl.obolibrary.org/obo/chebi#3_STAR
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_50266
chebi#is_conjugate_acid_of
http://purl.obolibrary.org/obo/CHEBI_59661
BFO_0000051
http://purl.obolibrary.org/obo/CHEBI_59671
22-rdf-syntax-ns#type
http://www.w3.org/2002/07/owl#Class