Discuss This Drug

colistimethate

CHEBI:CHEBI_59662

Definition

A mixture where R = H or Me. Colistin in which each of the primary amino groups is converted to the corresponding aminomethanesulfonic acid. It is prepared from colistin by the action of formaldehyde followed by sodium bisulfite. A polymyxin antibiotic, it is used as its penta-sodium salt in the treatment of severe infections, particularly of multidrug-resistant Gram-negative bacteria such as Pseudomonas aeruginosa and Acinetobacter baumannii.

Chemical Information

Molecular Formula
C57H107N16O28S5R
Molecular Mass
1624.883
Charge
0
SMILES
C(C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H]1C(N[C@H](C(N[C@@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(=O)NCC1)[C@@H](C)O)=O)CCNCS(O)(=O)=O)=O)CCNCS(O)(=O)=O)=O)CC(C)C)=O)CC(C)C)=O)CCNCS(O)(=O)=O)=O)=O)CCNCS(O)(=O)=O)=O)[C@@H](C)O)=O)CCNCS(O)(=O)=O)=O)CCC[C@@H](C*)C

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

core#notation
CHEBI:59662
oboInOwl#hasDbXref
DrugBank:DB01111
DRON_00010000
2708

Additional References

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Additional Attributes

brand_name_suffix
M
core#notation
CHEBI:59662
rxcui
1117525
pharm_class
Polymyxins [CS]
manufacturer_name
XGen Pharmaceuticals DJB, Inc.
active_ingredient_strength
150 mg/2mL
package_marketing_start_date
14-NOV-13
active_ingredient_name
COLISTIMETHATE SODIUM
package_description
120 VIAL, GLASS in 1 CASE (63552-010-03) / 6 mL in 1 VIAL, GLASS
unii
XW0E5YS77G
spl_set_id
6d6e13e2-dc33-4b7b-84d0-66146a57c552
upc
0339822061518
22-rdf-syntax-ns#type
http://www.w3.org/2002/07/owl#Class
oboInOwl#hasOBONamespace
chebi_ontology
oboInOwl#hasDbXref
DrugBank:DB01111
DRON_00010000
2708
oboInOwl#id
CHEBI:59662
generic_name
Colistimethate sodium
product_type
BULK INGREDIENT
marketing_category
BULK INGREDIENT
listing_expiration_date
20251231
dosage_form
INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION
route
INTRAVENOUS
marketing_start_date
20131114
labeler_name
Xellia Pharmaceuticals ApS
brand_name
Coly-Mycin M
brand_name_base
Coly-Mycin
product_ndc
45932-0015
spl_id
e0900b99-b8b1-4543-8692-ef92e051b466
package_ndc
45932-0015-2
application_number
NDA050108
chebi#has_functional_parent
http://purl.obolibrary.org/obo/CHEBI_37943
oboInOwl#inSubset
http://purl.obolibrary.org/obo/chebi#3_STAR
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_50266
chebi#is_conjugate_acid_of
http://purl.obolibrary.org/obo/CHEBI_59661
BFO_0000051
http://purl.obolibrary.org/obo/CHEBI_59671
rdf-schema#domain
https://w3id.org/def/predibionto#has_side_effect29669
chebi#is_conjugate_base_of
http://purl.obolibrary.org/obo/CHEBI_59661
owl#someValuesFrom
t571056
owl#annotatedSource
t255378