latanoprost

CHEBI:CHEBI_6384

Definition

A prostaglandin Falpha that is the isopropyl ester prodrug of latanoprost free acid. Used in the treatment of open-angle glaucoma and ocular hypertension.

Chemical Information

Molecular Formula: C26H40O5
Molecular Mass: 432.59280
Charge: 0
SMILES: CC(C)OC(=O)CCC\C=C/C[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1CC[C@@H](O)CCc1ccccc1
InChI: InChI=1S/C26H40O5/c1-19(2)31-26(30)13-9-4-3-8-12-22-23(25(29)18-24(22)28)17-16-21(27)15-14-20-10-6-5-7-11-20/h3,5-8,10-11,19,21-25,27-29H,4,9,12-18H2,1-2H3/b8-3-/t21-,22+,23+,24-,25+/m0/s1
InChIKey: GGXICVAJURFBLW-CEYXHVGTSA-N

Alternative Names

isopropyl (5Z,9alpha,11alpha,15R)-9,11,15-trihydroxy-17-phenyl-18,19,20-trinorprost-5-en-1-oate
isopropyl (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((3R)-3-hydroxy-5-phenylpentyl)cyclopentyl)-5-heptenoate
latanoprost
latanoprostum
PhXA 41
propan-2-yl (5Z)-7-{(1R,2R,3R,5S)-3,5-dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl]cyclopentyl}hept-5-enoate
Xalatan

Treatment Applications

residual stage of open angle glaucoma
DOID:1066

View Disease →
obsolete open angle with borderline glaucoma findings
DOID:13398

View Disease →
residual stage angle-closure glaucoma
DOID:1404

View Disease →
steroid-induced glaucoma - borderline
DOID:14548

View Disease →

Drug Classification

prostaglandins Falpha
CHEBI:36066

View Class →
triol
CHEBI:27136

View Class →
isopropyl ester
CHEBI:35725

View Class →
t265336
t265340
t266239
t266325
t266357

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

Always consult with a healthcare professional before starting, stopping, or modifying any medication.
Side effects may vary and this list may not be comprehensive.
Drug interactions may occur with other medications.

Additional Identifiers

DRON_00010000: 43611
oboInOwl#hasDbXref: Wikipedia:Latanoprost
core#notation: CHEBI:6384

Additional References

Wikipedia:Latanoprost

🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.

Additional Attributes

route: OPHTHALMIC
package_ndc: 62991-3186-1
package_description: 1 g in 1 BOTTLE, GLASS (62991-3186-1)
spl_id: 11450e7c-bbe6-b7fe-e063-6394a90adae7
manufacturer_name: Thea Pharma Inc.
package_marketing_start_date: 17-JUN-18
product_type: BULK INGREDIENT
marketing_category: BULK INGREDIENT FOR HUMAN PRESCRIPTION COMPOUNDING
listing_expiration_date: 20241231
labeler_name: Aspen Biopharma Labs Pvt Ltd
dosage_form: OIL
marketing_start_date: 20100213
application_number: ANDA218257
oboInOwl#hasOBONamespace: chebi_ontology
DRON_00010000: 43611
oboInOwl#hasDbXref: Wikipedia:Latanoprost
oboInOwl#id: CHEBI:6384
generic_name: Latanoprost Ophthalmic Solution 0.005%
brand_name: XELPROS
brand_name_base: XELPROS
product_ndc: 62991-3186
RO_0000087: http://purl.obolibrary.org/obo/CHEBI_50266
oboInOwl#inSubset: http://purl.obolibrary.org/obo/chebi#3_STAR
chebi#has_functional_parent: http://purl.obolibrary.org/obo/CHEBI_63925
core#notation: CHEBI:6384
rxcui: 2056748
pharm_class_epc: Prostaglandin Analog [EPC]
pharm_class: Prostaglandins [CS]
pharm_class_cs: Prostaglandins [CS]
active_ingredient_strength: 20 g/20g
active_ingredient_name: LATANOPROST
unii: 6Z5B6HVF6O
spl_set_id: 113abcc6-6e5c-4a57-ad6a-d69508ee990e
nui: M0017805
upc: 0364980516259
22-rdf-syntax-ns#type: http://www.w3.org/2002/07/owl#Class
has_treatment: http://purl.obolibrary.org/obo/DOID_13562
rdf-schema#range: https://w3id.org/def/predibionto#has_drug_108994
rdf-schema#domain: https://w3id.org/def/predibionto#has_side_effect30911
owl#annotatedSource: t266378
owl#someValuesFrom: t3382219