Pralatrexate
CHEBI:CHEBI_71223
Definition
A pteridine that is the N-4-[1-(2,4-diaminopteridin-6-yl)pent-4-yn-2-yl]benzoyl derivative of L-glutamic acid. Used for treatment of Peripheral T-Cell Lymphoma, an aggressive form of non-Hodgkins lymphoma.
Chemical Information
- Molecular Formula
- C23H23N7O5
- Molecular Mass
- 477.47260
- Charge
- 0
- SMILES
- Nc1nc(N)c2nc(CC(CC#C)c3ccc(cc3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)cnc2n1
- InChI
- InChI=1S/C23H23N7O5/c1-2-3-14(10-15-11-26-20-18(27-15)19(24)29-23(25)30-20)12-4-6-13(7-5-12)21(33)28-16(22(34)35)8-9-17(31)32/h1,4-7,11,14,16H,3,8-10H2,(H,28,33)(H,31,32)(H,34,35)(H4,24,25,26,29,30)/t14?,16-/m0/s1
- InChIKey
- OGSBUKJUDHAQEA-WMCAAGNKSA-N
Alternative Names
- (2S)-2-((4-((1RS)-1-((2,4-Diaminopteridin-6-yl)methyl)but-3-ynyl)benzoyl)amino)pentanedioic acid
- (2S)-2-({4-[1-(2,4-diaminopteridin-6-yl)pent-4-yn-2-yl]benzoyl}amino)pentanedioic acid
- 10-Propargyl-10-deazaaminopterin
- Folotyn
- HSDB 7786
- N-(4-(1-((2,4-Diamino-6-pteridinyl)methyl)-3-butynyl)benzoyl)-L-glutamic acid
- N-{4-[1-(2,4-diaminopteridin-6-yl)pent-4-yn-2-yl]benzoyl}-L-glutamic acid
- pralatrexate
- pralatrexato
- pralatrexatum
Treatment Applications
-
mature T-cell and NK-cell lymphomaView Disease →
DOID:0050743
-
peripheral T-cell lymphomaView Disease →
DOID:0050749
-
hepatosplenic T-cell lymphomaView Disease →
DOID:0081049
-
gastric lymphomaView Disease →
DOID:10540
-
testicular lymphomaView Disease →
DOID:12253
-
retroperitoneal lymphomaView Disease →
DOID:12339
-
obsolete lymphoma by siteView Disease →
DOID:1356
-
anus lymphomaView Disease →
DOID:14139
-
mediastinal gray zone lymphomaView Disease →
DOID:6867
-
thymus small cell carcinomaView Disease →
DOID:7142
-
gastrointestinal lymphomaView Disease →
DOID:903
Drug Classification
-
terminal acetylenic compoundView Class →
CHEBI:73477
-
N-acyl-L-glutamic acidView Class →
CHEBI:21650
-
pteridinesView Class →
CHEBI:26373
-
t279482
-
t279551
Important Medical Information
⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.
- Always consult with a healthcare professional before starting, stopping, or modifying any medication.
- Side effects may vary and this list may not be comprehensive.
- Drug interactions may occur with other medications.
Additional Identifiers
- DRON_00010000
- 662019
- oboInOwl#hasDbXref
- Wikipedia:Pralatrexate
- core#notation
- CHEBI:71223
Additional References
🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.
Additional Attributes
- oboInOwl#hasOBONamespace
- chebi_ontology
- DRON_00010000
- 662019
- oboInOwl#hasDbXref
- Wikipedia:Pralatrexate
- oboInOwl#id
- CHEBI:71223
- core#notation
- CHEBI:71223
- RO_0000087
- http://purl.obolibrary.org/obo/CHEBI_50683
- oboInOwl#inSubset
- http://purl.obolibrary.org/obo/chebi#3_STAR
- 22-rdf-syntax-ns#type
- http://www.w3.org/2002/07/owl#Class
- rdf-schema#range
- https://w3id.org/def/predibionto#has_drug_113547
- has_treatment
- http://purl.obolibrary.org/obo/DOID_1038
- owl#annotatedSource
- t280273
- owl#someValuesFrom
- t3020091