palbociclib

CHEBI:CHEBI_85993

Definition

A member of the class of pyridopyrimidines that is 2-{[5-(piperazin-1-yl)pyridin-2-yl]amino}pyrido[2,3-d]pyrimidin-7-one bearing additional methyl, acetyl and cyclopentyl substituents at positions 5, 6 and 8 respectively. It is used in combination with letrozole for the treatment of metastatic breast cancer.

Chemical Information

Molecular Formula: C24H29N7O2
Molecular Mass: 447.53280
Charge: 0
SMILES: CC(=O)c1c(C)c2cnc(Nc3ccc(cn3)N3CCNCC3)nc2n(C2CCCC2)c1=O
InChI: InChI=1S/C24H29N7O2/c1-15-19-14-27-24(28-20-8-7-18(13-26-20)30-11-9-25-10-12-30)29-22(19)31(17-5-3-4-6-17)23(33)21(15)16(2)32/h7-8,13-14,17,25H,3-6,9-12H2,1-2H3,(H,26,27,28,29)
InChIKey: AHJRHEGDXFFMBM-UHFFFAOYSA-N

Alternative Names

6-Acetyl-8-cyclopentyl-5-methyl-2-(5-piperazin-1-ylpyridin-2-ylamino)-8H-pyrido(2,3-d)pyrimidin-7-one
6-acetyl-8-cyclopentyl-5-methyl-2-{[5-(piperazin-1-yl)pyridin-2-yl]amino}pyrido[2,3-d]pyrimidin-7(8H)-one
IBRANCE
palbociclib
PD 0332991
PD 332991
PD-0332991
PD0332991
UNII-G9ZF61LE7G

Treatment Applications

obsolete breast papillary neoplasm
DOID:3015

View Disease →
obsolete intraductal papillary adenocarcinoma with invasion
DOID:5594

View Disease →
obsolete breast carcinoma metastatic to the brain
DOID:7304

View Disease →

Drug Classification

piperidines
CHEBI:26151

View Class →
aminopyridine
CHEBI:38207

View Class →
secondary amino compound
CHEBI:50995

View Class →
tertiary amino compound
CHEBI:50996

View Class →
pyridopyrimidine
CHEBI:38932

View Class →
aromatic ketone
CHEBI:76224

View Class →
cyclopentanes
CHEBI:23493

View Class →
t309962
t310898

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

Always consult with a healthcare professional before starting, stopping, or modifying any medication.
Side effects may vary and this list may not be comprehensive.
Drug interactions may occur with other medications.

Additional Identifiers

core#notation: CHEBI:85993
DRON_00010000: 1601374
oboInOwl#hasDbXref: Wikipedia:Palbociclib

Additional References

Wikipedia:Palbociclib

🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.

Additional Attributes

core#notation: CHEBI:85993
pharm_class: Kinase Inhibitors [MoA]
22-rdf-syntax-ns#type: http://www.w3.org/2002/07/owl#Class
rxcui: 2284108
route: ORAL
active_ingredient_strength: 150 kg/150kg
nui: N0000175082
pharm_class_moa: Kinase Inhibitors [MoA]
active_ingredient_name: PALBOCICLIB
package_marketing_start_date: 29-MAY-19
pharm_class_epc: Kinase Inhibitor [EPC]
manufacturer_name: U.S. Pharmaceuticals
package_ndc: 15308-2401-2
package_description: 5 kg in 1 PACKAGE (15308-2401-2)
unii: G9ZF61LE7G
spl_set_id: 86718885-da44-4d3d-b3ca-06cbcedcffd8
upc: 0300690187211
spl_id: 01d0d661-f717-787b-b758-50a0a291ef84
oboInOwl#hasOBONamespace: chebi_ontology
DRON_00010000: 1601374
oboInOwl#hasDbXref: Wikipedia:Palbociclib
oboInOwl#id: CHEBI:85993
generic_name: Palbociclib
product_type: BULK INGREDIENT
marketing_category: BULK INGREDIENT
listing_expiration_date: 20241231
dosage_form: CRYSTAL
marketing_start_date: 20150203
labeler_name: Chunghwa Chemical Synthesis & Biotech. Ltd
brand_name: Ibrance
brand_name_base: Ibrance
product_ndc: 15308-2401
application_number: NDA212436
RO_0000087: http://purl.obolibrary.org/obo/CHEBI_82665
oboInOwl#inSubset: http://purl.obolibrary.org/obo/chebi#3_STAR
has_treatment: http://purl.obolibrary.org/obo/DOID_5746
rdf-schema#range: https://w3id.org/def/predibionto#has_drug_112629
rdf-schema#domain: https://w3id.org/def/predibionto#has_side_effect37242
owl#annotatedSource: t310892
owl#someValuesFrom: t3499902