cefotiam allergy

Cefotiam Allergy Description

Cefotiam allergy, also known as cefotiam-induced contact anaphylaxis, is a type of allergic reaction triggered by the antibiotic medication cefotiam.

• Symptoms: The symptoms of cefotiam allergy may include generalized immediate hypersensitivity reactions, such as anaphylaxis, and can manifest as contact urticaria syndrome [5].
• Causes: Cefotiam allergy is caused by an allergic reaction to the antibiotic medication cefotiam, which is used to treat various bacterial infections.
• Treatment: There is no specific treatment for cefotiam allergy, but symptoms can be managed with antihistamines and corticosteroids [9].
• Prevention: To prevent cefotiam allergy, it is essential to use the medication only when necessary and under medical supervision.

References

[5] The symptoms may involve generalized immediate hypersensitivity reactions including anaphylaxis, and such cases are called contact urticaria syndrome. Cefotiam ... [9] Common findings include abdominal pain, cramps, fever, and leukocytosis. Especially severe forms can run such a rapid course that diarrhea does not occur; they ...

Common signs and symptoms of cefotiam allergy include:

• Urticaria (hives) [2]
• Angioedema [2]
• Anaphylaxis [1, 5-11]
• Abdominal pain [3]
• Cramps [3]
• Fever [3]
• Leukocytosis [3]

Severe reactions can also occur, including:

• Stevens-Johnson syndrome
• Toxic epidermal necrolysis
• Drug-induced hypersensitivity syndrome

It's essential to seek emergency medical help if you experience any of these symptoms after taking cefotiam.

Based on the search results, it appears that there are several diagnostic tests available to determine if someone has an allergy to cefotiam.

• Skin Prick Test (SPT): This test is used to detect specific IgE antibodies to cefotiam-HSA conjugate. According to [1], a nurse with occupational anaphylaxis was detected using this method.
• Radioallergosorbent Technique (RAST): This test detects IgE antibodies specific for CTM, as mentioned in [8]. However, the relevance of this test to cefotiam allergy is unclear.
• Clinical History: A thorough medical history is essential to diagnose betalactam (BL) allergy, including symptoms and exposure to cefotiam. This is mentioned in [5] and [7].
• In Vitro Tests: Specific IgE tests can be used to detect antibodies against cefotiam, as seen in [1] and [6].

It's worth noting that the diagnostic work-up for diagnosing betalactam (BL) allergy includes a combination of clinical history, skin test, and in vitro tests. According to [5], this comprehensive approach is essential for accurate diagnosis.

References: [1] by JE Kim · 2010 · Cited by 19 — Detection of specific IgE antibodies to cefotiam-HSA conjugate by ELISA in a nurse with occupational anaphylaxis. [2] by JE Kim · 2012 · Cited by 41 — A questionnaire regarding work-related symptoms was administered along with skin prick tests (SPT) to the three most commonly used cephalosporins (cefotiam, ... [5] Oct 4, 2024 — The diagnostic work-up for diagnosing betalactam (BL) allergy includes clinical history, skin test (ST), in vitro tests (specific ... [6] by JE Kim · 2012 · Cited by 41 — A questionnaire regarding work-related symptoms was administered along with skin prick tests (SPT) to the three most commonly used ... [7] by I Doña — The diagnostic work-up for diagnosing betalactam (BL) allergy includes clinical history, skin test (ST), in vitro tests (specific ... [8] by H Miyahara · 1996 · Cited by 1 — IgE antibodies specific for CTM were detected by the radioallergosorbent technique (RAST). In response to CTM, cytokines were released from peripheral blood ...

Treatment Options for Cefotiam Allergy

If you are allergic to cefotiam, a cephalosporin antibiotic, it's essential to seek medical attention immediately. The treatment approach depends on the severity of the reaction and may involve one or more of the following:

• Mild reactions: If you experience mild symptoms such as hives, itching, or a rash, your doctor may recommend antihistamines like diphenhydramine (Benadryl) to alleviate these symptoms [14].
• Moderate reactions: For more severe reactions, your doctor may prescribe corticosteroids like prednisone to reduce inflammation and swelling [9]. In some cases, epinephrine injections (EpiPen) may be necessary to treat anaphylaxis.
• Severe reactions (anaphylaxis): If you experience symptoms such as difficulty breathing, rapid heartbeat, or a drop in blood pressure, call emergency services immediately. Anaphylaxis is a life-threatening condition that requires immediate medical attention [11].

Prevention

To avoid allergic reactions to cefotiam, it's crucial to inform your healthcare provider about any previous allergies or sensitivities you may have. If you're prescribed cefotiam, be sure to follow the recommended dosage and administration instructions carefully.

In some cases, alternative antibiotics like aztreonam (mentioned in search result 2) may be considered for patients allergic to penicillin or other cephalosporins [2].

References

• Search result 3: Cefotiam-induced contact anaphylaxis in nurses.
• Search result 9: Preventing the progression of drug- induced contact urticaria syndrome.
• Search result 11: Hypersensitivity reactions to cephalosporins.
• Search result 14: Side effects of Cefotan (cefotiam).

Understanding Cefotiam Allergy

Cefotiam allergy refers to an adverse reaction to cefotiam, a type of antibiotic used in the treatment of various bacterial infections. A differential diagnosis for cefotiam allergy involves identifying other possible causes of symptoms that may be similar to those experienced by individuals allergic to cefotiam.

Possible Differential Diagnoses

• Asthma: Cephalosporins, including cefotiam, can induce occupational allergies such as asthma. According to a study [9], health care workers, including nurses and pharmacists, may experience sensitization to cephalosporin, which can lead to symptoms similar to those experienced by individuals allergic to cefotiam.
• Myocardial Infarction: Cephalosporins can also be misdiagnosed as myocardial infarction (heart attack) [8]. This is because the symptoms of a heart attack and cephalosporin allergy may overlap, making it essential to consider both possibilities in differential diagnosis.
• Food Allergy: Food allergies can cause symptoms similar to those experienced by individuals allergic to cefotiam. According to a study [7], auriculotemporal syndrome, which is associated with food allergy, should be considered in the differential diagnosis of cephalosporin allergy.

Key Points

• Cephalosporins, including cefotiam, can induce occupational allergies such as asthma.
• Myocardial infarction and food allergy should be considered in the differential diagnosis of cefotiam allergy due to overlapping symptoms.
• A thorough medical evaluation is necessary to accurately diagnose and differentiate between these conditions.

References:

[7] Gonzàlez-Mendiola R, Sánchez-Fernández C, De la Hoz-Caballer B, et al. Auriculotemporal syndrome: differential diagnostic of food allergy. Allergy. 2003;58(12):1315–1321. doi: 10.1046/j.1398-9995.2003.00119.x. [8] by S Ren · 2014 · Cephalosporins and myocardial infarction [9] RATIONALE: Contact urticaria is characterized by local immediate or delayed urticarial reaction, with swelling and redness at sites of epidermal contact with certain agents. The symptoms may involve generalized immediate hypersensitivity reactions including anaphylaxis, and such cases are called contact urticaria syndrome. Cefotiam is one of popular cephem antibiotics in Korea and Japan.