4 free views remaining today
obsolete Coxiella burnetii hepatitis
ICD-10 Codes
Description
Based on the search results, it appears that Coxiella burnetii hepatitis, also known as Q fever hepatitis, has been associated with various clinical and pathological features.
Historical Context Q fever was first described in Australia in 1937 [7], and since then, its manifestations have been documented. In the past, Q fever hepatitis was considered a rare manifestation of the disease.
Clinical Features According to search result 6, granulomatous hepatitis as the sole manifestation of acute Q fever has been reported only rarely. However, minimal hepatic dysfunction may be common in the acute disease [6].
Pathological Features Search result 8 mentions that the pathological features of liver biopsies from patients with Q fever have not been well described. This suggests that there is limited information available on the specific pathological changes associated with Coxiella burnetii hepatitis.
Comparison to Modern Understanding It's worth noting that our understanding of Q fever and its manifestations has evolved over time. While the search results provide some insight into the historical context of Coxiella burnetii hepatitis, they also highlight the limitations of past research in this area.
In summary, while there is limited information available on the description of obsolete Coxiella burnetii hepatitis, it appears that Q fever was associated with various clinical and pathological features in the past. However, further research would be needed to fully understand the historical context of this disease manifestation.
References: [6] Granulomatous hepatitis as the sole manifestation of acute Q fever has been reported only rarely, although minimal hepatic dysfunction may be common in the acute disease. [7] Q fever was first described in Australia in 1937. [8] The pathological features of liver biopsies from patients with Q fever have not been well described.
Additional Characteristics
- Coxiella burnetii hepatitis
- Q fever hepatitis
- granulomatous hepatitis
- minimal hepatic dysfunction
- liver biopsies
Signs and Symptoms
Based on the provided context, it appears that Coxiella burnetii hepatitis is not entirely obsolete, but rather a chronic manifestation of Q fever infection.
Chronic Hepatitis Manifestations
According to search result [10], Coxiella burnetii infection can cause both acute and chronic illness. In the case of chronic hepatitis, symptoms may include:
- Chronic hepatitis (search results [7] and [8])
- Vasculitis
- Osteomyelitis
- Osteoarthritis
- Chronic pulmonary infection
These manifestations are often seen in individuals who have been exposed to infected animals or contaminated environments.
Symptoms of Chronic Hepatitis
While the exact symptoms may vary, chronic hepatitis caused by Coxiella burnetii infection can manifest as:
- Endocarditis (search results [1] and [7])
- Chronic vascular infections
- Osteomyelitis
- Osteoarthritis
It's essential to note that not all individuals infected with Coxiella burnetii will develop chronic hepatitis or these symptoms. In fact, up to half of infected people may remain asymptomatic (search result [12]).
Treatment and Prevention
Effective treatment and vaccines are available for Q fever infection, which can help prevent the development of chronic manifestations like hepatitis. However, if left untreated, Coxiella burnetii infection can lead to severe complications.
References:
[1] Anderson A. Potential signs and symptoms include endocarditis, chronic hepatitis, chronic vascular infections, osteomyelitis, osteoarthritis, and ... [7] Mar 29, 2013 — Potential signs and symptoms include endocarditis, chronic hepatitis, chronic vascular infections, osteomyelitis, osteoarthritis, and chronic ... [8] Aug 17, 2023 — Other manifestations of chronic Q fever include chronic hepatitis, vasculitis, osteomyelitis, osteoarthritis, chronic pulmonary infection [10] Coxiella burnetii is the causative agent of Q fever. Q fever is a zoonotic disease seen mostly in people who work with farm animals. While most of the cases remain asymptomatic, the symptomatic patients most commonly develop a febrile illness. Effective treatment and vaccines are available for this condition. However, if not treated appropriately, it can become a chronic infection affecting ... [12] Q fever, caused by the bacteria Coxiella burnetii, can
Additional Symptoms
- Osteoarthritis
- Chronic hepatitis
- Chronic pulmonary infection
- Chronic vascular infections
- endocarditis
- obsolete osteomyelitis
- vasculitis
Diagnostic Tests
Based on the available information, it appears that there are various diagnostic tests for Coxiella burnetii infections, but I couldn't find any specific mention of "obsolete" Coxiella burnetii hepatitis.
However, I can provide some general information on the diagnosis of Coxiella burnetii infections. According to search result [4], serology is the most common modality used for diagnosing Q fever, and confirmation of disease may take several weeks to months to detect the required 4-fold increase in antibody titers.
The diagnosis of Coxiella burnetii infections can be complex, as mentioned in search result [2]. Currently, the diagnosis is mainly based on positive serological tests. The original diagnosis was often based on characteristic "ring" granulomas on a bone marrow biopsy specimen and confirmed by complement-fixation antibody tests (search result [3]).
It's worth noting that the detection of C. burnetii nucleic acid via PCR in blood or other bodily fluids is also used for diagnosis, as mentioned in search results [8] and [10].
As for obsolete diagnostic tests, I couldn't find any specific information on this topic. However, it's possible that older tests may have been replaced by more modern and accurate methods.
Here are some general points to consider:
- Serology is the most common modality used for diagnosing Q fever.
- The diagnosis of Coxiella burnetii infections can be complex and often based on positive serological tests.
- Detection of C. burnetii nucleic acid via PCR in blood or other bodily fluids is also used for diagnosis.
- Older diagnostic tests may have been replaced by more modern and accurate methods.
References:
[4] AB Jama · 2023 · Cited by 1 — Serology is the most common modality used for diagnosing Q fever, and confirmation of disease may take several weeks to months to detect the required 4-fold increase in antibody titers. [2] by I Das · 2014 · Cited by 10 — The diagnosis of Coxiella endocarditis is, therefore, often complex. Currently, the diagnosis is mainly based on positive serological tests. [3] by SH YALE · 1994 · Cited by 42 — The original diagnosis was often based on characteristic “ring” granulomas on a bone marrow biopsy specimen and confirmed by complement-fixation antibody tests. [8] Aug 17, 2023 — Diagnosis of acute and chronic Q fever is based mainly upon serologic testing or detection of C. burnetii organisms or DNA (via PCR) in blood ... [10] Detection of C. burnetii nucleic acid is also used for diagnosis.
Additional Diagnostic Tests
- Serology
- PCR in blood or other bodily fluids
- Complement-fixation antibody tests
Treatment
Treatment Options for Obsolete Coxiella burnetii Hepatitis
Coxiella burnetii hepatitis, also known as Q fever hepatitis, is a rare but serious infection caused by the bacterium Coxiella burnetii. While it's considered obsolete in modern medical practice, understanding its treatment options can provide valuable insights.
Historical Treatment Approaches
In the past, treatment for C. burnetii hepatitis was primarily focused on managing symptoms and supporting patient recovery. According to various studies [1][2], doxycycline was often used as a first-line treatment for acute Q fever, including cases with granulomatous hepatitis.
Current Treatment Recommendations
More recent guidelines suggest that a prolonged combined antimicrobial regimen is recommended for chronic C. burnetii infections [4]. The addition of hydroxychloroquine to doxycycline has been shown to be effective in treating chronic Q fever [5].
- Doxycycline remains the first choice of treatment for acute Q fever.
- For chronic Q fever, a combination of doxycycline and hydroxychloroquine is recommended.
Additional Treatment Considerations
In some cases, hospitalization may be necessary to manage severe symptoms or complications [4]. Antibiotic therapy, including ciprofloxacin and doxycycline, has been used in conjunction with other treatments for extended periods [6].
- Hospitalization may be required for severe cases.
- Combination antibiotic therapy may be necessary for prolonged treatment.
References
[1] Anderson A. Doxycycline as the drug of choice for treatment of acute Q fever in adults. (Context 1)
[2] Crespo M. Case study: Steroid use in patients with granulomatous hepatitis complicating C. burnet
Recommended Medications
💊 Drug information is sourced from ChEBI (Chemical Entities of Biological Interest) database. Always consult with a healthcare professional before starting any medication. Click on any medication name for detailed information.
Differential Diagnosis
The differential diagnosis for Coxiella burnetii hepatitis, specifically the obsolete variant, involves considering various conditions that present with similar symptoms.
According to search results [4][8], the differential diagnosis of fever of unknown origin (FUO) includes infectious, neoplastic, rheumatic-inflammatory, and miscellaneous diseases. This suggests that Coxiella burnetii hepatitis should be considered among other potential causes of FUO.
In terms of specific conditions that may present with similar symptoms to Coxiella burnetii hepatitis, the following are worth noting:
- Other bacterial infections: Such as leptospirosis or brucellosis, which can cause fever, headache, and liver dysfunction [5].
- Viral hepatitis: Including acute viral hepatitis A, B, C, D, and E, which can present with similar symptoms to Coxiella burnetii hepatitis [6].
- Autoimmune hepatitis: Such as primary biliary cirrhosis or autoimmune hepatitis type 1, which can cause liver dysfunction and fever [7].
- Malignancies: Including lymphoma or leukemia, which can cause fever, weight loss, and liver dysfunction [4].
It's essential to note that the differential diagnosis for Coxiella burnetii hepatitis may vary depending on the specific clinical presentation and patient history.
References:
[4] Aguilar-Olivos N. (2013) [5] YALE SH. (1994) [6] Anderson A. (no date) [7] El-Mokhtar MA. (2022) [8] (no author) (2023)
Additional Differential Diagnoses
- Other bacterial infections
- Malignancies
- viral hepatitis
- autoimmune hepatitis
Additional Information
- rdf-schema#domain
- https://w3id.org/def/predibionto#has_symptom_275
- owl#annotatedSource
- t328164
- oboInOwl#hasOBONamespace
- disease_ontology
- oboInOwl#id
- DOID:0050221
- core#notation
- DOID:0050221
- IAO_0000115
- A Q fever that involves inflammation of the liver caused by Coxiella burnetti, which results in the formation of granulomas. The symptoms include fever, malaise, hepatomegaly with right upper abdominal pain, and jaundice.
- rdf-schema#label
- obsolete Coxiella burnetii hepatitis
- oboInOwl#hasExactSynonym
- Q fever hepatitis
- owl#deprecated
- true
- oboInOwl#inSubset
- http://purl.obolibrary.org/obo/doid#zoonotic_infectious_disease
- relatedICD
- http://example.org/icd10/A78
- 22-rdf-syntax-ns#type
- http://www.w3.org/2002/07/owl#Class
Medical Disclaimer: The information provided on this website is for general informational and educational purposes only.
It is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified healthcare provider with questions about your medical condition.