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MEDNIK syndrome

ICD-10 Codes

Related ICD-10:

M06.81 M60.871 M61.43 M77.50 M99.30 P35 Q64 Q68 T32.31 E75.2 E75.23 E79.82 H15.052 M02.34 M06.82 M41 M42.19 M86.252 M86.569 M89.263 M99.61 T56.1X G71.0341 M11.141 M25.62 M61.541 M77 M86.159 M90.54 M90.542 Q64.71 S14.154 C85.28 E77 G71.0340 H35.8 I67.7 Q72 Q72.3 C84.16 G05.4 G37.3 H05.023 H36.81 I69.26 I82.5 L13.1 M61.26 M89.29 T39.1X5 D61 H18.54 H18.543 I45.5 L90.0 M12.07 M12.072 M41.40 M54.01 M76.8 D72 H05.021 H16.059 H91.23 K74.2 M23.31 M86.15 M86.152 M89.21 M89.52 D59.39 E88 E88.A G47.14 I69.36 K50.019 M67.8 M87.88 N02.B6 A41.02 A66.6 H05.1 H61.02 H61.021 L23.0 M12.511 M86.112 Q63 S24.4 B78.0 E06.2 E26.02 M02.0 M02.35 M84.611 M87.363 N07.0 Q40.2 Q61.1 Q61.19 H21.81 J63.2 M02.319 M25.00 M89.729 M99.3 N07 N07.8 Q71.4 Q75.01 R22.42 D13.91 H11.04 H71.21 K14.2 M00.03 M05.54 M12.141 M89.429 N80.3B C91.50 E70.81 G90.5 H15.043 M25.832 M43.08 M50.023 M89.167 S12.3 Z82 C88.20 D50.1 H16.403 M05.86 M71.879 M85.43 M90.56 M92.219 M99.2 Q93.52 B46.1 H18.45 H18.452 I67.3 M02.351 M25.83 M61.131 M86.122 Q71.53 Q72.4 A39.3 G60.8 H02.519 M61.25 M87.263 N04.4 B42.82 E79.0 H18.32 H18.323 M05.51 M12.46 M21.92 M67.824 M89.322 Q78.4 E74.3 G00.1 G12.8 M76.89 M84.869 M89.15 P72.8 Q21.15 I82.5Y3 M61.3 M87.034 Q78.0 E64.8 G56.01 H53.6 M12.442 M87.33 Q38.7 C47 C47.9 G57.13 H30.013 H80.8 M00.17 M00.172 M12.1 M12.11 M13.111 M89.18 M99.35 Q98 Q98.1 S52.241 D60.8 R29.90 E70.331 M54.14 M84.8 Q71.5 G40.841 H01 I02.9 M33.11 M80.82 M84.832 M87.251 Q73 G92.0 H02.824 H18.549 H35 H35.0 M48.35 S43.305 D81.8 E77.8 H68.123 K85.02 M67.931 A26.7 I82.C22 M25.81 M25.812 M90.53 R25.9 S73.02 H02.042 K85.12 L66.3 M05.421 M24.021 M35 N02.4 I82.3 M33.0 M47.014 M61.219 M61.45 Q21.14 Z22.340 A08.11 H01.141 H35.89 M05.371 M12.471 M86.532 M86.612 M87.87 M87.875 M99.10 P09 Q25.4 C37 H02.22A H47.20 K80.31 M88.87 P25 P54.5 H02.152 H05.243 H15.823 H71.22 M05.85 M06.9 Q45.2 G31.8 H81.391 H92 I65 M62.5 M67.93 M89.239 Q91.5 Z15 Z15.8 D89.42 E75.24 E75.249 H74.31 L20.81 Q66.7 D69.5 D86.84 E70.40 H26.03 H26.032 M06.372 M07.60 M61.439 Q71 R83.3 G04.32 H35.063 Q70.4 E74.39 I31.3 I31.31 Q78.2 H52.51 J93 J93.1 M24.23 M96.A N07.6 S73.0 G04.3 M11.08 M87.336 A50.55 G58.8 I82.5Y M1A.171 M24.232 M24.47 M41.114 M93.212 Q87.84 S52.60 T26.5 T26.52 E26.81 G11.11 H11.4 H50.81 K83.4 M92.60 Q61.5 R70 I80.251 M87.022 T86.0 E75.29 L03.89 M21.16 M70.93 M89.13 A39.50 E07.0 L67 M06.349 M11.81 M87.89 M99.7 S43.315 T32.97 G12.0 G57.4 G57.43 H02.2 M46.2 Q77 A44.8 H15.04 H68 H80.2 M25.0 M48.1 M86.351 N18 N80.3B9 S63.29 D69.4 E75 F06 I78.8 M02.01 M05.52 M21.331 M87.029 M89.03 N06.2 G90.2 M11.04 M26.79 M43.03 M48.31 M87.111 Q25.3 S93.13 S93.135 M61.4 Q60.4 Q71.41 D89 G37.4 H02.51 H35.053 M00.84 M14.68 M60.142 M61.2 M61.469 E20.810 M67.85 M89.01 M89.019 M89.22 M89.221 M92.42 T50.B15 D57.03 H04.159 H11.012 K86 M06.331 M63.82 M90.59 Q44.1 Q66.82 S43.312 B57.42 D56.5 E75.28 H26.033 J63 Q37.8 Q61.11 S34.124 S63.24 D89.8 D89.89 G95.8 G95.81 H15.09 H18.523 M21.23 M92.52 N04.21 C72.42 G40.802 H18.063 M21.37 M62.472 M84.82 E20.81 G57.42 H18.593 M11.24 M46.81 M87.271 Z98.890 C91.6 M86.129 D68.318 E72.03 I45.10 M62.81 M86.342 M87.171 A04.6 J84.84 M00.879 M11.012 M11.16 M85.631 M89.39 M92.21 D57.4 E76.22 I82.C11 M87.033 M88.81 M89.55 Q71.0 Q71.01 S52.28 A39.1 E85.3 M25.05 M99.73 A56.09 E75.26 G71.02 M11.06 M75.31 M87.353 M92.5 S60.82 S60.821 E74.12 G40.01 G95.89 G95.9 M12.051 M89.153 S04.0 H18.553 J44 M48.10 M61.177 M61.211 M61.542 M89.461 Q90.1 G40.844 M47.13 E74.05 H30.1 H35.20 L41.4 M24.221 M86.261 M89.128 M89.362 M89.43 M89.431 Z15.1 D51.1 D82.8 M24.451 M89.165 E27.0 E74.829 M24.211 M61.512 M94.8X7 Q07.02 Q80.3 M85.64 K11.8 M94.29 D57.431 M89.8X7 D55.21 M60.172 R83.6 M93.841 K50.114 M05.849 M61.122 M93.879 Q76.3 S64.12 G40.842 K63.8211 H02.21C H16.39 M89.02 Q91.2 B92 D82.0 H18.713 J67.8 H15.051 I72.2 M25.642 Q93.9 S23.150 A69.21 A96.8 M61.039 B38.7 D57.43 S40.22 M96.A1 M24.532 S14.157 M67.972 Q44.0 R22 Q76.41 I66.8 I75.8 M67.95 S00.52 H74.313 S53.134 E71.30 H15.12 H16.413 M13.84 M13.842 M25.07 M53.84 M61.472 M87.373 E00 E00.0 E74.2 H40.23 S22.42 D77 H26.063 H80.00 K50.814 M00.121 M11.061 M25.631 S00.42 M12.40 Q91.4 L95.1 B78.7 P91.823 D81.810 E75.09 H47.29 L14 M14.62 M61.461 M92.62 O36.821 T65.3X1 A32.1 E71.19 M62.59 M89.8X9 M99.4 J14 M86.32 M86.322 S90.82 E71.32 G95.0 H18.833 H20.023 M85 D51.2 H33.193 M46.24 M61.242 M86.679 Q75.4 H04.813 M43.5X4 M86.162 M99.43 D70.4 M67.87 G31.81 G56.1 G56.13 I63.429 I82.511 M60.85 M71.82 M71.821 M92.40 S90.42 E80.5 I63.519 M12.06 M25.671 Q16.4 Q71.81 D36.1 D61.0 E75.240 H20.2 K06.023 M02.27 M06.832 M48.8X M61.144 M87.819 M90.552 Q22.8 Z83.43 A75.3 M07.69 M46.5 M61.0 M93.00 Q30.2 Q67.5 E71.50 G00.2 G81.1 Q79.61 T32.30 E72.59 H35.723 M26.70 M87.019 M87.234 M89.123 O36.82 S83.19 C96.5 I63.119 M00.26 M87.031 N04.0 Q51.821 S60.322 I87.029 Q71.6 Q87.81 B06.02 E34.321 H02.433 M25.612 M41.11 M86.339 M86.031 M47.10 A74.89 Q39.9 L10.3 M48.12 E88.43 S12.69 G90.09 N52.03 T80.218 Q51.8 T34.522 E71.53 E61.5 P01.2 M87.132 S14.111 M62.271 P58.8 E32.9 S24.159 Q72.52 G56.11 H18.832 S52.389 M06.342 I08.3 L97.326 L40.1 M86.412 M87.264 M61.061 K50.119 M35.03 N02.B2 M70.62 G40.B01 Q21.9 Q91.6 G56.93 M93.99 M87.212 H18.591 I66.2 M43.8X4 M61.172 C85.27 M85.679 Q72.33 M48.23 L90.8 H33.192 C08.0 M62.431 Z80.51 G12.22 M86.029 H35.733 M87.039 E75.27 M14.65 M84.852 M12.132 M89.012 M89.541 P15.6 E51.8 M60.041 H80.03 E75.243 F07.0 M61.042 Q71.22 M12.321 M35.04 Q71.23 Q42.1 M12.121 M86.562 H61.032 K50.113 G40.411 H90.42 M86.242 M87.871 D57.414 I69.911 T32.20 M41.44 M86.312 S53.131 M11.122 M61.549 M11.071 L73.8 Q82.0 J84.848 M11.231 G04.30 H18.629 M31.5 M75.02 M86.251 H18.7 N01.3 N06.5 G25.89 M25.549 H18.79 I82.C23 L66.4 M65.859 C81.43 H21 M61.01 N02.3 B56.1 H18.503 M08.08 M61.239 S34.101 G82.52 M11.09 M91.81 S53.111 M87.011 M87.059 M12.071 M84.671 T50.4X5 A44 B58.2 L10.1 L51.1 M1A.031 M61.121 M87.08 S13.150 H83.8X M24.622 M99.72 M61.29 H60.20 M12.13 M62.532 S53.01 H81.03 M24.222 M12.172 M67.49 M99.71 Q62.69 H44.2A1 I69.89 M06.831 M86.022 M87.044 P96.0 M61.559 M89.761 M10.471 M89.732 M92.70 T34.5 M87.874 Q25.8 K08.23 M62.53 E85.8 J96.92 M99.79 R90.81 E85.2 Q81.1 G71.12 K08.22 Q16.9 L98.416 M61.49 M85.89 E75.242 I63.532 M02.329 M66.3 M89.163 A79.1 D57.412 M71.21 Q79.1 G93.8 M87.045 E71.542 M86.652 R77.0 G57.02 M92.50 D89.49 H47.21 S14.115 B58.83 I82.A13 M00.051 M53.2X8 M61.241 M86.9 M87.038 H65.4 E71.510 E72.21 G37.81 S12.20 D81.81 M46.94 Q25.41 T84.89 E20.818 I77.8 K80.36 M05.451 Q38.4 D86.81 H70.89 M14.83 S14.158 H73.813 M93.821 S60.521 C96.29 G57.1 M11.00 M11.18 Q74.3 H83.1 M61.151 M89.061 P29.30 E71.520 E76.03 H18.311 M42.00 Q67.1 G40.30 H70.223 K50.813 M84.811 S43.111 L40.2 M11.221 M12.832 N63.3 E31.21 M84.812 I69.819 M41.50 M86.332 M86.662 M87.329 P58 T56.4X4 E80.0 Q70.23 Q76.415 T34.012 B26.1 H80.10 L97.816 M89.251 M89.41 M90.531 S93.33 D57.44 E74.00 G11.0 Q55.7 S12.2 M85.83 Q80.1 D73.89 J67 M11.02 M11.021 M11.029 M41.112 M61.539 Q97.9 S25.0 C71.2 N70.1 M60.12 G40.B1 H53.433 G40.B19 M08.251 M21.512 Q04 Q81 R76.12 H05.402 G96.198 H21.253 Q72.13 S13.17 C96.9 E72.04 H35.17 M87.86 M87.861 M89.54 H18.0 H18.02 Q71.63 D84.8 H05.123 L98.8 N31 Q60.1 S53.135 T84.059 T86.30 Z16 E10.2 M67.9 Q84.1 S60.822 E16.9 L94.1 M86.139 R71 G40.8 J34.8 M85.619 N11.1 S53.133 C96.0 M61.18 R90 E80 E80.7 L92.8 M61.222 M71.31 M86.36 M97.8 B60.09 D47.0 M41.26 M65.95 Q78 M60.122 N80.D P11 S92.31 M85.9 T34.81 E79.8 E79.89 H18.532 M50.12 M61.12 M86.54 M86.622 S52.382 E31.20 G44.0 G60.0 H18.831 I43 M02.82 S34.121 H18.333 M06.37 P58.9 Q75.9 S63.11 A77.2 D68.09 E74.20 H26.06 I07.8 I65.21 J4A M60.19 M89.229 S83.11 H35.071 I69.391 K63.8212 M05.352 M05.45 M42.02 M89.521 P14.3 E83.8 G57.22 M61.571 M91.20 Q40 M12.4 M21.221 T50.Z15 T84.611 G54.8 M08.812 M76.9 G96.8 M10.43 S89.0 M11.82 Q72.812 T34.51 Z87.762 E70.9 H54.3 M71.531 M86.329 L73.2 Q97.3 T85.820 M42.01 M89.312 Q38.3 I73.1 L41.5 M93.25 K59.3 L89.156 M14.831 M1A.152 M51.16 D73.2 E76.0 E76.01 M61.072 T32.77 G25.69 G56.21 N04.20 Q72.41 Q76.6 M86.172 M86.65 T78.3 H18.719 N02.B1 N02.B9 M88.811 M89.551 G37.1 I63.312 L98 L98.7 Q71.12 Z15.02 E70.20 G51.9 M71.852 Q17.8 I69.853 M88.821 Q45.0 M02.87 M89.133 I63.213 M10.431 G12.20 M48.17 M62.551 M94.35 E71.12 E74.81 H02.21 H70.203 I87.023 M05.461 M65.822 M47.01 M47.011 M71.871 L74.8 M02.822 R15.9 S63.013 E54 M24.21 M86.8X1 Q12 Q12.1 E75.244 G90.3 H18.022 M12.03 M61.143 M86.149 M86.561 Q72.02 Z87.760 F78.A1 M1A.09 M02.361 Q78.3 N02.1 D57.434 E75.241 G71.09 M80.871 M93.90 M89.129 E13.42 M12.0 S90.421 Z86.3 H21.22 H21.229 M12.00 M67.47 M87.235 Q77.8 M05.47 H30.81 P94.8 G31.86 M61.58 Q75.04 H26.043 I82.539 M87.066 T45.4X5 M1A.311 M93.979 M99.44 Q13.8 G73 J62 L74.9 R62.5 C85.17 E61.4 E88.01 G56.03 I82.549 M11.261 M86.641 M90.571 Q70.01 E71.529 M61.261 M87.159 M89.359 H02.721 M89.559 A75.2 M26.52 M61.41 Q97 H80.13 M07.622 M12.87 M11.0 M89.132 C85.2A I69.851 M25.87 S83.131 G71.034 M31.9 M61.452 G31.80 H16.411 M25.076 D57.459 H02.512 I74.11 L65.8 L81.7 L87.2 M60.112 A85.0 E71.440 J95.3 N01.A H35.43 M75.30 M87.375 N00.9 N07.A S23.122 S30.825 D57.452 M86.511 M88.1 M26.07 M86.452 Q70.9 G62.9 D69.8 H35.022 M12.02 M60.149 M48.26 Q38.8 C81.41 E71.312 M12.451 A74 M12.042 M84.839 Q85.09 J84.10 J85.3 Q21.13 M61.14 I63.342 I69.341 S42.02 M12.872 M86.59 H27 M85.672 Q91.3 R79.83 I37.2 M85.639 G11.5 M12.31 M71.89 K51.018 Q37.2 E74.8 M94.8X0 B57.49 G71.22 M11.039 M84.863 S52.283 G56.22 M12.179 M71.842 Q78.9 S12.550 L90.1 Q25.29 E72.51 B60.11 H16.441 H18.40 H60.323 M86.341 M05.8A M60.072 M61.53 M85.432 M87.162 S12.6 M41.41 O35.1 A42.8 D47.3 I89 Q72.50 H02.725 I82.891 M88.89 M93.251 D78.3 H33.03 H49.43 K51.21 T34.4 H33.031 M66.24 T86.39 M61.019 M86.62 M87.335 M93.831 T85.733 D81.32 E74.82 L57.2 M61.479 M86.119 E70.321 I82.569 K62.4 L03.122 M86.519 M90.519 R89.4 M47.20 M89.23 M89.231 R77.8 T56.0X H11.059 G51.31 G90.50 K74.3 S23.110 P61.1 G40.C M85.649 M87.821 M87.850 Q81.2 R62.50 L97.214 M25.80 R56.01 M12.111 H90.6 M89.042 N36.43 S90.822 H18.542 L90.2 M13.831 M89.131 M61.51 M87.829 M84.833 M86.439 R26.9 K95 M61.462 Q71.891 Q77.3 H18.59 Z82.0 D57.00 M87.232 D64.0 Q69.9 Q70.02 M67.01 H02.23C H35.722 I87.01 M86.29 M87.877 D46.2 D47.4 H80.11 M89.021 M12.18 M89.432 Q71.812 D74.8 L89.304 M12.561 M1A.01 N80.D1 L89.812 M71.169 S13.14 T85.860 M88.832 M07.631 Q32.2 M13.832 E89.40 M33.12 S52.282 M12.08 M92.7 M71.421 H21.261 M61.161 E72.22 M06.319 M1A.18 L94.8 M60.841 S24.141 M24.642 M49.87 M24.631 E80.29 M25.872 M94.351 M89.160 A36.82 E83.9 M42.07 N01.6 E60 G57.70 N01.8 I69.361 D55.8 M13.819 P09.4 S43.392 M12.43 G47.34 S64.11 P74.31 T34.53 T82.827 M47.15 M87.334 M89.569 Q93.89 D48.2 E27 H80.23 M02.362 M61.10 M86.239 N00.4 N02.B5 M87.141 M89.411 Q87.82 M62.23 M67.83 M86.46 D70.0 I66.03 I82.53 M02.271 M65.26 Q62.11 A50.01 E83.59 G51.2 G71.032 H90.1 S24.15 I80.252 M89.8X6 Z87.731 N02.6 S93.14 S93.142 E70.320 E80.20 G47.35 H70.2 M08.971 M87.063 Q71.892 T86.00 D68.2 H44.32 M86.221 S23.130 T32.55 M93.852 N80.3B3 D76 H33.053 J84.83 M11.20 M86.8X8 M87.035 M87.18 M92.1 H05.323 M08.839 M49.88 M87.188 S63.0 E75.5 S62.2 R70.1 G57.40 M11.85 M62.252 S53.14 T32.88 E70.328 E78.70 M60.111 M84.65 M89.333 M89.5 S13.12 Z16.29 M12.431 M61.46 M89.072 O35.14 M11.171 M21.852 M87.85 M87.851 P59.1 Q93.0 S83.132 E71.313 M86.629 M10.459 M24.259 M71.4 M86.61 C92.1 E71.111 E70.310 M12.05 M12.062 M87.052 Q75.042 S23.163 S34.132 H50.611 I69.31 M25.861 N00.5 M86.55 A77.40 H69.83 M1A.48 M86.352 E75.0 M11.051 M12.38 M65.862 T32.92 G71.03 M11.052 M24.69 H05.411 M06.339 M08.00 Q93.7 C4A.39 M87.822 M89.372 G23.0 G24.1 I01 M86.64 D55.2 I31 M11.172 M93.83 M99.20 P05.15 H18.513 M61.032 T86.858 E78.71 H04.8 M85.66 M87.838 M87.864 N17.2 Q39.8 D78.8 H35.173 M12.449 M86.249 S90.423 E72.23 I28.9 M00.14 M89.70 Q87.85 Z31.440 M08.872 M27.1 M87.841 M25.073 M46.08 M47.897 M87.13 M93.912 Q71.33 S62.29 M60.83 M87.377 M89.77 S93.31 E71.311 L74 M11.031 M51.A2 M61.13 M86.151 R25.1 L89.511 M87.83 M89.361 M84.87 M99.37 Q11.1 A66.3 G40.42 M12.361 M61.272 M76.81 M77.20 H16.052 M08.052 N03.5 Q82.3 C81.0 I20.8 E76 E76.3 G43.619 H47 I82.56 L20.8 M11.062 M93.8 S24.11 M06.232 M86.48 E74 H33.032 I89.8 M89.542 M92.02 N04.6 E16.8 E72.20 I50.82 M60.129 N01.0 S02.40 D61.89 G40.801 K83 M12.17 M47.2 M87.869 Q37.5 D82.9 H35.449 M02.18 M61.9 M89.126 Q07.9 Q18.8 Q41.8 Q72.5 Q72.51 C86 J01.31 T32.71 H18.52 H50.811 M40.293 M84.631 Q90.2 Q91.7 E74.820 H02.04 H02.041 K55.012 L97.524 M05.241 M11.011 M31.8 M65.912 M86.26 M89.72 M89.721 N25 Q17.1 G40.811 H81.0 M62.47 M87.274 M89.05 G80.1 M62.48 M65.85 M89.442 O45.01 Q23.82 R94.0 S44.40 E50.3 M23.321 Q10.7 D81.39 E84.1 M24.676 M62.562 M92.292 S62.01 H47.01 H47.012 H53.413 M60.152 M85.0 M85.08 E83.32 H21.9 H95.0 H95.02 J84.81 P83.30 Q33 S13.111 E74.810 C88.3 H81.01 I48.11 M72.4 M92.202 S42.017 B10.01 D57.438 G04.39 M65.269 H61.011 M25.45 M42.18 M99.34 Q71.50 H44.2A9 I82.562 M12.41 M23.34 M47.891 H15.82 M86.512 C4A.4 M87.072 Q72.91 E27.40 H62.42 J44.81 M13.879 Q26.8 Q55.3 E01.0 H30.12 I69.352 M89.332 Q23.9 H40.14 M02.332 M41.56 M89.50 R47.1 S13.151 E71.52 H04.013 H31.2 L90.4 M20.5 M86.621 M87.376 Q44.6 Q87 H18.722 D57.413 G90.8 K13.7 M60.13 N03.4 Q24.4 M00.05 M61.069 Q66.89 S23.11 M86.38 A44.0 M24.659 M85.431 M87.341 Q72.03 D81.818 M34.89 M54.0 I89.9 L11.8 M67.853 P28.4 Z87.71 H57.8 M12.332 Q76.4 Q93.3 S90.425 N31.8 Q90.0 S35.239 H18.31 K56.49 M89.739 G60.9 H05.401 H16.402 M21.26 M86.642 M87.15 M87.150 E83.111 M12.33 M89.09 M89.752 M91.9 Q72.40 M12.159 Q14.8 Q40.0 G93.42 M89.779 N16 Q32.4 T32.90 E88.811 G46.8 H18.03 H18.033 H90.0 M15.9 M33 M87.145 S14.153 T32.50 T32.86 G24.9 G71.0349 H35.061 J92.0 L12.3 M89.412 T32.82 B56.0 D23.4 E72.10 G83.89 H16.143 M02.30 M25.04 M26.611 G71.8 H18.33 T57.2X H26.052 I82.723 M05.221 M21.762 M93.87 A52.12 G11.6 H02.22C H15.029 I47.21 L68.1 L87.0 L97.921 M11.161 S63.240 E00.2 G57.73 H02.515 M24.61 M24.612 M91.0 N04.8 J84.113 M00.2 M05.821 M05.841 M08.879 M77.5 M77.52 M86.659 M92.29 M23.32 M25.879 Q25.40 M02.23 M80.832 A39.0 H49.33 M05.50 P56.90 Q71.2 M06.86 M89.27 N03.3 A02.21 H16.203 M43.05 M50.02 N05.5 A39.5 M02.3 R77.9 L67.8 M05.219 M92.32 Q21.2 S50.322 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M00.25 M62.441 S34.5 D82.3 G71.228 S13.110 S53.13 D72.110 D80.9 H02.516 H35.2 M41.3 M46.59 M60.811 Q33.6 S12.59 Z87.728 D81.4 M11.019 M60.132 D51.9 M86.23 M86.34 M94.3 N02.5 N18.4 Z16.11 M67.814 E20.0 H30.811 M61.551 M92.211 M94.8X5 Q06.9 L66.8 M72.8 Q31.1 E71.448 M50.33 D82.2 G56.12 M05.479 S43.21 M02.352 Q61.2 T80.211 M25.51 D83.0 L85.8 M86.18 I99 S23.17 B02.21 I74.01 M1A.19 M35.4 M42.14 M87.322 P91.63 E71.42 E88.89 M11.07 C47.8 M1A.44 M61.221 Q72.60 M11.831 G90.523 M08.039 P74.5 M24.251 M60.161 M93.861 S35.348 S63.072 E71.118 E71.548 M43.11 M53.2X4 M71.819 M87.02 M87.021 I69.290 M26.613 M87.062 M90.672 I44.39 K50.819 M02.88 M53.83 M87.14 H35.731 M89.712 T84.625 E72.9 G57.80 L66.1 K56.5 M61.141 M87.845 M89.261 S43.394 J41.1 M71.2 M71.811 H04.1 H27.113 M42.06 C4A.21 G90.B M06.36 M08.059 M87.831 Q62 M61.50 M92.229 M92.30 N07.5 M06.25 M61.561 M86.432 C48.8 H35.021 M25.261 M33.09 M89.28 Q79.8 A31.2 M12.151 G57.93 M87.844 Q34.1 M60.84 M86.131 M86.421 E75.02 M05.462 Q75.029 T84.621 M05.39 T84.63 P96.82 E71.110 M61.532 N15.0 S52.531 M24.571 M86.549 M48.8X1 M84.872 M92.291 E13.620 M92.12 M02.339 M61.16 I82.531 M21.72 M86.632 M91.90 N31.1 S14.114 G37.2 P71.1 M61.17 M65.83 H61.039 G40.B M46.03 H74.321 K05.213 T32.80 L66.81 N01.7 I82.532 M92.511 Q33.8 M87.852 Q17 B68.0 H02.439 M61.119 M84.752 G89.21 S40.829 I74.3 M99.38 E74.01 M87.051 G71.3 M08.4 M61.40 E71.540 G44.091 M61.162 G96.89 H70.891 M66.111 N28.8 I77.5 M02.39 M89.76 M87.129 M62.432 M89.462 M89.73 M89.471 M11.032 M89.07 E72.52 M08.831 M43.3 M89.79 P35.8 K85.82 M61.229 I25.81 H49.81 M43.4 H61.031 L75.8 M89.511 Q71.819 S22.43 G31.89 G90.1 I82.542 T36.5X5 M84.662 M93.261 Q64.39 L28.1 M89.032 J63.0 E80.2 H04.033 Q93.4 I08.8 P76.2 E72.29 H35.029 M86.362 M34.8 M41.02 M89.371 M66.231 N61.23 Q75.1 M86.35 Q76.412 M61.259 O45.011 M65.231 M24.662 H02.70 P78.84 L12.2 Q85.81 M60.162 M87.180 N02.B4 D86.83 M43.5X8 K80.46 H30.813 M87.074 Q79.60 H35.63 E10.29 M02.851 M87.250 I40.9 M62.442 I82.A22 M85.071 Q80.4 D80.2 M25.572 R34 N07.1 M93.839 D76.2 E75.4 M61.22 E70.311 H04.213 Q74.1 M94 M12.049 H33.033 H66.23 D89.82 T84.031 I82.543 D48.118 M31.2 M62.211 S93.131 M61.271 G51.8 M02.05 M86.331 H17.11 M61.09 M05.611 Q62.7 M84.754 M86.531 M12.86 H18.51 M11.861 Q07.00 M06.38 M62.46 H53.69 M89.751 H16.433 Q74.0 E79.2 Q64.5 E74.31 M24.64 M48.13 M89.772 N25.8 G71.13 L12.0 M88.839 Q50.39 T56.5X1 M84.864 E70.8 M31.19 M86.49 H21.221 M02.09 G31.82 G56.43 M24.41 N12 E06.5 E63.8 M46.33 M86.311 C85.21 G36.0 H18.592 D60.9 N13.72 H26.039 M26.653 G57.03 M24.274 M86.8X7 M89.369 N01.9 H15.059 Q11.2 H35.04 Q77.5 E75.00 S63.248 M31.7 Q42.0 E74.09 M87.064 G61.9 K80.60 T56.6X4 M61.252 Q68.4 G57.50 M62.5A0 H02.513 D46.1 D46.C H90.7 T56.7X4 M60.019 M86.10 H31.129 D81.5 M61.431 E72.02 M05.31 M21.862 M87.036 M87.142 P12.3 Q70.12 Q87.3 M05.811 M33.10 K00.0 H80.21 E71.522 M00.13 M92.512 Q34.8 T82.6 M25.649 M89.124 O36.822 I73.0 M89.169 M05.762 M86.09 M62.269 M00.29 M89.8X5 M93.872 G57.71 M05.532 M89.49 M87.012 Q52.8 H18.451 M43.09 M87.859 M89.011 M99.66 H61.022 M85.451 B42.1 M62.3 C81.33 E76.8 E73.0 H74.391 N05.0 N25.89 M65.812 E83.49 C92.60 M61.23 M86.171 E51.2 J84.843 S63.126 M90.55 M50.13 M86.232 H10.51 N01.5 G70.80 M06.862 M86.132 N07.4 R83.9 C74.90 Q72.63 E71.314 E74.29 M24.649 M40.37 E34.328 M89.422 T42.2X5 D81.30 H26.069 M71.431 M89.125 H15.023 M92.592 D51.0 Z86.6 M92.4 M89.762 M61.28 S62.391 H44.532 N50.8 M25.03 S40.822 H31.29 H49.813 Q55.4 E76.9 M87.272 B43.2 M05.431 A79.81 H05.119 H80.01 M89.259 Q78.1 M33.90 M86.572 Q72.32 M93.222 M05.249 K13.24 M61.279 M86.13 M47.16 H35.739 H15.033 Z88.2 M86.24 M00.071 H16.442 I69.891 E72.53 G58.0 L89.154 Q75.5 E75.25 H15.091 M86.41 E71.318 M61.511 M89.71 T27.5 M40.202 L03.126 D72.829 Q78.6 M24.639 M87.061 Q76.8 G95.19 J96.21 M25.074 M87.345 H15.093 M54.02 M80.87 Q82.8 I69.311 M47.26 M89.041 M94.8X1 D81.7 M08.959 M33.03 M87.041 M90.512 Q66.1 R20.2 M06.841 M89.051 M89.272 M90.50 P91.829 Q41.1 E72.09 M06.332 S83.134 N49.2 M06.351 M61.269 M62.279 H55.09 M00.052 M05.222 M11.25 M86.419 H15.822 M61.572 M84.531 M88.82 M92.9 Q71.43 B26.85 G57.63 N07.2 A84.0 H11.011 K31.A15 R09.A1 K76.89 H26.031 M41.05 H20.823 M21.83 M14.67 M61.249 H80.82 T34.72 M47.9 G37.5 H35.443 K51.313 L44.4 M25.061 Q32 M24.632 H05.823 M61.051 N27.0 I69.212 N28.81 T81.328 H74.323 A19.1 E71 G71.20 I77.89 J63.3 M86.212 G98.0 M11.832 P72.0 O62.4 T56.5X4 M65 M89.532 S53.093 C96.6 M21.763 H18.711 S52.6 C85.22 M11.872 G40.821 H61.03 I69.364 M47.016 G40.83

Description

MEDNIK syndrome, also known as mental retardation, enteropathy, deafness, neuropathy, ichthyosis, and keratodermia, is a rare genetic disorder characterized by several severe symptoms.

Key Features:

  • Intellectual Disability: Individuals with MEDNIK syndrome often experience impaired intellectual development, leading to intellectual disability [1][2].
  • Enteropathy: The condition involves inflammation of the intestines, which can lead to digestive issues and malabsorption of nutrients [3].
  • Deafness: Sensorineural hearing loss is a common symptom of MEDNIK syndrome, affecting an individual's ability to hear sounds [4].
  • Peripheral Neuropathy: This condition affects the nerves outside the brain and spinal cord, leading to numbness, tingling, or pain in the extremities [5].
  • Ichthyosis: A skin disorder characterized by dry, scaly, or thickened skin, often accompanied by keratodermia (a type of skin thickening) [6][7].

Additional Information:

MEDNIK syndrome is an autosomal recessive disorder, meaning that a person must inherit two copies of the mutated gene (one from each parent) to develop the condition. The AP1S1 gene mutations are responsible for causing MEDNIK syndrome [8].

Additional Characteristics

  • Ichthyosis
  • Intellectual Disability
  • Peripheral Neuropathy
  • Enteropathy
  • Deafness

Signs and Symptoms

MEDNIK syndrome, also known as mental retardation, enteropathy, deafness, neuropathy, ichthyosis, keratoderma syndrome, is a rare genetic disorder characterized by a combination of severe multisystem symptoms. The signs and symptoms of MEDNIK syndrome include:

  • Impaired intellectual development: Individuals with MEDNIK syndrome often experience significant delays in cognitive development, leading to intellectual disability [1][2].
  • Enteropathy: This refers to a condition affecting the small intestine, which can lead to malabsorption of nutrients and other complications [3].
  • Deafness: Sensorineural hearing loss is a common feature of MEDNIK syndrome, affecting an individual's ability to hear and communicate effectively [4][5].
  • Peripheral neuropathy: This refers to damage or disease affecting the nerves outside the brain and spinal cord, leading to symptoms such as numbness, tingling, and weakness in the limbs [6][7].
  • Ichthyosis: A condition characterized by dry, scaly skin that can be painful and itchy [8].
  • Keratoderma: This refers to a thickening of the skin on the palms and soles, which can lead to discomfort and difficulty with mobility [9].

These symptoms often appear together in individuals with MEDNIK syndrome, although their severity and progression may vary from person to person.

Additional Symptoms

  • Ichthyosis
  • Peripheral neuropathy
  • Impaired intellectual development
  • Enteropathy
  • Keratoderma
  • deafness

Diagnostic Tests

MEDNIK syndrome, also known as Erythrokeratodermia Variabilis type 3 (EKV3), is a rare disorder characterized by intellectual deficit, enteropathy, sensorineural hearing loss, peripheral neuropathy, and other systemic features.

Diagnostic Tests:

  • Laboratory testing can help confirm the diagnosis of MEDNIK syndrome. This may include:
    • Intermittent elevation of transaminases [6]
    • Elevated total bile acids
    • Reduced serum copper and ceruloplasmin
    • Increased serum free fatty acids
    • Abnormal amino acid profiles in blood [5]
  • Molecular diagnosis of MEDNIK syndrome can be performed through genetic testing, specifically for the AP1S1 gene. This type of testing is recommended to identify a potential genetic basis for the condition and inform prognosis [9].
  • Diagnostic tests may also include:
    • Blood cell count
    • Amino acid profiles in blood
    • Essential fatty acid levels
    • Zinc, homocysteine, folic acid, and vitamin B12 levels

It's essential to consult with a healthcare professional or a genetic counselor for accurate diagnosis and guidance on the most suitable diagnostic tests.

References: [5] Further studies in blood (e.g. cell count, amino acids, essential fatty acid, zinc, homocysteine, folic acid and vitamin B12) and urine ... [6] Laboratory testing showed intermittent elevation of transaminases, elevated total bile acids, reduced serum copper and ceruloplasmin, increased serum free ... [9] AP1S1. Diagnostic testing of this gene is recommended to identify a potential genetic basis for a condition. This type of testing can inform prognosis and ...

Additional Diagnostic Tests

  • Blood cell count
  • Laboratory testing
  • Molecular diagnosis through genetic testing (AP1S1 gene)
  • Amino acid profiles in blood
  • Essential fatty acid levels
  • Zinc, homocysteine, folic acid, and vitamin B12 levels

Treatment

MEDNIK syndrome, also known as Erythrokeratodermia Variabilis type 3 (EKV3), is a rare disorder of copper metabolism characterized by intellectual deficit, enteropathy, sensorineural hearing loss, and peripheral neuropathy.

Treatment Options

According to the search results, zinc acetate therapy has been suggested as a treatment option for MEDNIK syndrome. This therapy has been shown to improve clinical conditions, reduce liver copper overload, and decrease serum free copper levels [1][2].

  • Zinc acetate treatment can help alleviate symptoms such as intellectual deficit, enteropathy, sensorineural hearing loss, and peripheral neuropathy.
  • The therapy involves administering 50 mg/day of zinc acetate orally.

Effectiveness

Studies have demonstrated the effectiveness of zinc acetate therapy in treating MEDNIK syndrome. For example, a study published in Brain found that zinc acetate treatment strikingly improved clinical conditions, as well as liver copper and bile-acid overload [1].

  • Zinc acetate therapy can lead to decreased serum free copper levels, transaminases, and total bile acids.
  • The treatment also results in increased blood ceruloplasmin levels.

Current Status

As of 2024, zinc acetate therapy is considered a viable treatment option for MEDNIK syndrome. In fact, liver copper overload can now be listed as a copper metabolism defect in humans that is treatable by zinc acetate therapy [7].

References:

[1] D Martinelli (2013) - Zinc acetate treatment strikingly improved clinical conditions, as well as liver copper and bile-acid overload. [2] D Martinelli (2013) - Given the similarities to Wilson's disease, we attempted oral zinc acetate therapy (50 mg/day) to reduce liver copper overload. [7] Oct 22, 2024 - Liver copper overload is treatable by zinc acetate therapy, and can now be listed as a copper metabolism defect in humans.

Recommended Medications

  • Zinc Acetate Therapy

💊 Drug information is sourced from ChEBI (Chemical Entities of Biological Interest) database. Always consult with a healthcare professional before starting any medication. Click on any medication name for detailed information.

Differential Diagnosis

MEDNIK syndrome, also known as mental retardation, enteropathy, deafness, neuropathy, ichthyosis, keratodermia syndrome, is a rare genetic disorder caused by mutations in the AP1S1 gene. When considering differential diagnoses for MEDNIK syndrome, several other conditions should be taken into account.

  • Huppke-Brendel syndrome: This is another rare genetic disorder that presents with similar symptoms to MEDNIK syndrome, including intellectual disability, enteropathy, and ichthyosis [5][8].
  • CCS chaperone deficiency: This condition also shares some similarities with MEDNIK syndrome, such as congenital cataracts, sensorineural deafness, and low serum copper and ceruloplasmin levels [7].
  • Other copper metabolism disorders: Recent studies have identified a new copper metabolism disorder characterized by congenital cataracts, sensorineural deafness, and low serum copper and ceruloplasmin levels, which may also be considered in the differential diagnosis of MEDNIK syndrome [10].

It's essential to note that each of these conditions has distinct features and diagnostic criteria. A comprehensive evaluation, including genetic testing and clinical assessment, is necessary to accurately diagnose MEDNIK syndrome and rule out other potential causes.

References: [5] - Context result 5 [7] - Context result 7 [8] - Context result 8 [10] - Context result 10

Additional Differential Diagnoses

  • CCS chaperone deficiency
  • Other copper metabolism disorders
  • N syndrome

Additional Information

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