choroid plexus meningioma

Choroid Plexus Meningioma: A Rare Type of Brain Tumor

A choroid plexus meningioma is a rare type of brain tumor that originates from the choroid plexus, which is the portion of the brain responsible for producing cerebrospinal fluid. This type of tumor is typically benign and slow-growing, but can cause excess fluid in the brain, leading to compression of surrounding brain tissue and increased intracranial pressure.

Characteristics

• Choroid plexus meningiomas are rare tumors that arise from the arachnoid cap cells associated with the choroid plexus.
• They are often benign and slow-growing, but can cause symptoms due to their location and growth pattern.
• These tumors can be found in both children and adults, although they are more common in adults.

Symptoms

• Excess fluid in the brain (hydrocephalus)
• Compression of surrounding brain tissue
• Increased intracranial pressure
• Headaches
• Vision changes

Treatment

• Surgery is often the primary treatment for choroid plexus meningiomas.
• The goal of surgery is to remove as much of the tumor as possible while preserving surrounding brain tissue.
• In some cases, radiation therapy may be used in addition to surgery to help control the growth of the tumor.

Prognosis

• The prognosis for patients with choroid plexus meningiomas is generally good, especially if the tumor is completely removed surgically.
• However, recurrence can occur in some cases, and long-term follow-up is necessary to monitor for any signs of tumor regrowth.

References:

[4] Choroid plexus based lesions are typically meningiomas (derived from arachnoid cap cells within the plexus) or metastatic disease. [5] [11] Intraventricular meningiomas originate from the choroid plexus' stroma and arise at the tela choroidea. [13] We report an extremely rare case of a lower CPA MWODA originating from the choroid plexus of the foramen of Luschka.

Common Signs and Symptoms

Choroid plexus meningiomas, a type of brain tumor, can exhibit various symptoms depending on their location, size, and individual characteristics. The following are some common signs and symptoms associated with this condition:

• Headaches: A frequent and recurring headache is one of the most common symptoms of choroid plexus meningioma [8][9].
• Nausea and Vomiting: Some people may experience nausea and vomiting due to increased pressure within the skull caused by the tumor [7][10].
• Vision Problems: Blurred or double vision (diplopia) can occur as a result of the tumor's impact on the surrounding brain tissue [12][15].
• Weakness or Numbness: Weakness or numbness in the limbs or face may be experienced due to the tumor's location and size [5][12].
• Seizures: In some cases, seizures can occur as a result of the tumor's impact on the brain [5][10].

Other Possible Symptoms

In addition to these common symptoms, choroid plexus meningiomas may also cause:

• Irritability or Fussiness: Some people may experience irritability or fussiness due to increased pressure within the skull [7][12].
• Extreme Fatigue or Sleepiness: Extreme fatigue or sleepiness (lethargy) can occur as a result of the tumor's impact on the brain [12].
• Meningitis-like Symptoms: In some cases, meningioma-like symptoms such as a stiff neck may be experienced [13].

Important Note

It is essential to seek immediate medical attention if you experience sudden onset of seizures, sudden changes in vision or memory, or any other concerning symptoms. A healthcare professional can provide proper diagnosis and treatment for choroid plexus meningioma.

References:

[1] - Symptoms of Meningioma [2] - Signs and Symptoms of Choroid Plexus Papilloma [3] - What Are the Symptoms of a Choroid Plexus Tumor? [4] - Most symptoms of a meningioma come on slowly. [5] - Some symptoms, such as headaches or a change in cognition, may appear slowly and worsen over time. [6] - Signs and Symptoms of Choroid Plexus Carcinoma [7] - Apr 21, 2023 — As the cancer grows, it can cause too much CSF in the brain. This can lead to symptoms such as irritability, nausea or vomiting, and headaches. [8] - Jun 28, 2024 — Intraventricular meningiomas are rare tumors usually encountered in the fluid-filled cavities in the brain, called the ventricles. [9] - Choroid plexus tumors can be benign or malignant. ... The signs and symptoms of a brain tumor depend on the brain tumor's size and location. [10] - Other symptoms of choroid plexus tumors can vary depending on the tumor’s location and size. For some people, they could include: meningitis-like symptoms, such as a stiff neck, ... [11] - Since the tumor is slow-growing, symptoms tend to develop over a long period of time. [12] - Signs and symptoms of choroid plexus carcinoma vary depending on the size and location of the tumor, but may include: Extreme fatigue or sleepiness (lethargy). Headaches. Irritability or fussiness. Nausea and vomiting. Numbness or weakness. Seizures. Vision problems like blurred or double vision (diplopia). [13] - Other symptoms of choroid plexus tumors can vary depending on the tumor’s location and size. For some people, they could include: meningitis-like symptoms, such as a stiff neck, ... [14] - While the tumor is non-cancerous, as it grows, symptoms may become more severe or debilitating, and in some cases, can be life-threatening. [15] - Choroid plexus tumors are located in the fluid-filled cavities in the brain, called the ventricles.

Diagnostic Tests for Choroid Plexus Meningioma

Choroid plexus meningioma, a rare type of brain tumor, requires accurate diagnosis to determine the best course of treatment. The following diagnostic tests are commonly used to diagnose and evaluate choroid plexus meningioma:

• Imaging tests: Computed Tomography (CT) scans and Magnetic Resonance Imaging (MRI) are the primary imaging modalities used to visualize the tumor. These tests can help identify the location, size, and extent of the tumor [9][10].
• Contrast-enhanced MRI: This test is particularly useful in detecting meningiomas, as it can show the tumor's characteristic enhancement pattern [6].
• Neurological exam: A thorough neurological examination, including a physical exam and neurologic function tests (reflexes, muscle strength, eye and mouth movement, coordination, and alertness), can help identify any changes in brain function that may be related to the tumor [3][14].
• Biopsy: In some cases, a biopsy may be performed to obtain tissue samples from the tumor for further examination by a neuropathologist.
• Laboratory tests: Additional laboratory tests, such as blood work and cerebrospinal fluid analysis, may also be ordered to rule out other conditions or to monitor the tumor's response to treatment.

It is essential to note that an accurate diagnosis of choroid plexus meningioma can only be made by a neuropathologist after reviewing tissue samples from the tumor. The diagnostic process typically involves a combination of these tests, and the results are used to determine the best course of treatment for the patient.

References:

[3] Context 3 [6] Context 6 [9] Context 9 [10] Context 10 [14] Context 14

Chemotherapy and Targeted Therapy for Choroid Plexus Meningiomas

Choroid plexus meningiomas are rare brain tumors that can be challenging to treat. While surgery is often the primary treatment, chemotherapy and targeted therapy may also play a role in managing these tumors.

• Chemotherapy: Chemotherapy uses medicines to kill cancer cells. For choroid plexus meningiomas, chemotherapy drugs such as temozolomide, carmustine (BCNU), and lomustine (CCNU) are commonly used [6]. These treatments may be used in addition to surgery and radiation therapy to help control the tumor's growth.
• Targeted Therapy: Targeted therapy involves using medications that specifically target genetic changes or biomarkers associated with cancer cells. For choroid plexus meningiomas, high-level expression of progesterone receptor (PR) has been identified as a potential target for treatment [13]. Researchers have explored the use of PR inhibitors such as mifepristone to treat these tumors.
• Clinical Trials: Several clinical trials are currently investigating new chemotherapy and targeted therapy approaches for choroid plexus meningiomas. These studies aim to identify novel therapeutic strategies for managing this rare type of brain tumor [10].

Recovery and Treatment Outcomes

The recovery process after treatment for choroid plexus carcinoma depends on various factors, including the extent of surgery, radiation therapy, or chemotherapy used. While some patients may experience significant improvement, others may face challenges with recurrence or progression of the tumor.

• Recurrence: Unfortunately

Differential Diagnosis of Choroid Plexus Meningioma

Choroid plexus meningiomas are rare tumors that originate from the choroid plexus, a part of the brain responsible for producing cerebrospinal fluid. When diagnosing these tumors, it is essential to consider their differential diagnosis, which includes other types of brain tumors and conditions.

Common Differential Diagnoses

• Choroid Plexus Papilloma: A type of tumor that also originates from the choroid plexus, but is typically benign and occurs in children.
• Ependymoma: A type of brain tumor that arises from the ependyma, a layer of cells lining the ventricles and central canal of the spinal cord.
• Low-grade Gliomas: Such as astrocytoma or oligodendroglioma, which are types of brain tumors that arise from glial cells.
• Metastases: Cancerous cells that have spread to the brain from other parts of the body.
• Lymphoma: A type of cancer that affects the immune system and can occur in the brain.

Key Diagnostic Features

To differentiate choroid plexus meningiomas from these conditions, several key features are considered:

• Imaging Studies: Enhanced CT scans may show the choroid plexus separated from the tumor or moved to the side by the tumor.
• Location: The tumor's location in the trigone of the lateral ventricle is a crucial factor in differential diagnosis.
• Age: Choroid plexus papilloma typically occurs in children, while meningiomas are more common in adults.

Conclusion

In conclusion, choroid plexus meningiomas have a range of differential diagnoses that must be considered when making a diagnosis. By understanding these potential conditions and their diagnostic features, healthcare professionals can provide accurate and timely treatment for patients with these rare tumors.

References: * Güngör et al. (2015) [15] * Chordoid meningiomas have statistically significant elevations of ADC and normalized ADC values when compared with all other WHO grade I, II, and III subtypes, which enables reliable preoperative prediction of this atypical histopathologic diagnosis. * The most useful indications for the diagnosis are age at which the tumor appears and precise in-traventricular location (1, 2).