Discuss This Drug

Lomustine

CHEBI:CHEBI_6520

Definition

An N-nitrosourea that is urea in which one of the nitrogens is substituted by a 2-chloroethyl group and by a nitroso group, while the other nitrogen is substituted by a cyclohexyl group. An alkylating antineoplastic agent, it is used in the treatment of brain tumours, lung cancer, malignant melanoma and other solid tumours.

Chemical Information

Molecular Formula
C9H16ClN3O2
Molecular Mass
233.69500
Charge
0
SMILES
ClCCN(N=O)C(=O)NC1CCCCC1
InChI
InChI=1S/C9H16ClN3O2/c10-6-7-13(12-15)9(14)11-8-4-2-1-3-5-8/h8H,1-7H2,(H,11,14)
InChIKey
GQYIWUVLTXOXAJ-UHFFFAOYSA-N

Alternative Names

  • 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea
  • 1-(2-Chloroethyl)-3-cyclohexyl-1-nitrosourea
  • 1-(2-chloroethyl)-3-cyclohexylnitrosourea
  • Belustine
  • CCNU
  • Cecenu
  • CeeNU
  • chloroethylcyclohexylnitrosourea
  • CINU
  • cyclohexyl chloroethyl nitrosourea
  • lomustina
  • lomustine
  • lomustinum
  • N-(2-chloroethyl)-N'-cyclohexyl-N-nitrosourea

Treatment Applications

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

DRON_00010000
6466
oboInOwl#hasDbXref
Wikipedia:Lomustine
core#notation
CHEBI:6520

Additional References

Wikipedia:Lomustine

🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.

Additional Attributes

oboInOwl#hasOBONamespace
chebi_ontology
DRON_00010000
6466
oboInOwl#hasDbXref
Wikipedia:Lomustine
oboInOwl#id
CHEBI:6520
generic_name
LOMUSTINE
product_type
BULK INGREDIENT
marketing_category
BULK INGREDIENT
listing_expiration_date
20241231
route
ORAL
dosage_form
CAPSULE, GELATIN COATED
marketing_start_date
20230729
labeler_name
MAEDA INC
package_marketing_start_date
29-JUL-23
brand_name
Gleostine
brand_name_base
Gleostine
product_ndc
55111-965
application_number
NDA017588
spl_id
055a7f60-63ac-09b4-755f-f4a7e424e709
package_ndc
55111-965-00
package_description
1 kg in 1 DRUM (55111-965-00)
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_22333
oboInOwl#inSubset
http://purl.obolibrary.org/obo/chebi#3_STAR
core#notation
CHEBI:6520
rxcui
1545780
active_ingredient_strength
1 kg/kg
pharm_class_moa
Alkylating Activity [MoA]
pharm_class
Alkylating Drug [EPC]
pharm_class_epc
Alkylating Drug [EPC]
nui
N0000175558
manufacturer_name
NextSource Biotechnology, LLC
active_ingredient_name
LOMUSTINE
unii
7BRF0Z81KG
spl_set_id
7f77526b-4c40-409c-82ea-d0f934d89cc2
22-rdf-syntax-ns#type
http://www.w3.org/2002/07/owl#Class
has_treatment
http://purl.obolibrary.org/obo/DOID_6128
owl#annotatedSource
t269203
owl#someValuesFrom
t696981
rdf-schema#range
https://w3id.org/def/predibionto#has_drug_113724