obsolete skin abnormality

Based on the provided context, it appears that there are several references to an "obsolete collagen nevus" or "collagen nevus of skin". However, without further information, it's difficult to provide a detailed description.

From search result [2] and [5], we can see that "Collagen hamartoma (morphologic abnormality)" is mentioned alongside "Collagen naevus", which might be related to the obsolete collagen nevus. However, there isn't enough context to provide a clear definition of this condition.

It's worth noting that search result [4] discusses Pseudoxanthoma elasticum (PXE), a multisystem orphan disease, but it doesn't seem directly related to an "obsolete collagen nevus".

If you could provide more information or clarify what you're looking for, I'd be happy to try and assist further.

Based on the provided context, it appears that there are various skin abnormalities mentioned, but I'll focus on identifying an "obsolete" one.

After reviewing the search results, I found a few mentions of rare or outdated skin conditions. However, I couldn't pinpoint a specific condition that is widely considered "obsolete." Nevertheless, I can provide some information on a few lesser-known skin conditions:

• Pseudoxanthoma elasticum (PXE): This is a multisystem orphan disease that affects the skin, eyes, and cardiovascular system [9]. While not entirely obsolete, it's a rare condition.
• Ehlers-Danlos Syndrome (EDS): People with a type of EDS may have other skin characteristics and symptoms, such as unusual skin texture, skin fragility, very thin skin, delayed wound healing, and others [3].

However, I couldn't find any information on an "obsolete" skin abnormality. It's possible that the term "obsolete" refers to a condition that was once well-known but is no longer commonly discussed or recognized.

If you could provide more context or clarify what you mean by "obsolete," I'd be happy to try and assist you further.

References: [3] - People with a type of EDS may also have other skin characteristics and symptoms, such as unusual skin texture, skin fragility, very thin skin, delayed wound healing... [9] - Pseudoxanthoma elasticum (PXE), a multisystem orphan disease, clinically affects the skin, the eyes, and the cardiovascular system with considerable morbidity...

Treatment Options for Obsolete Skin Abnormalities

Obsolete skin abnormalities, such as actinic keratosis and vitiligo, can be effectively treated with various medications and therapies.

• Chemoprevention: Nicotinamide, acitretin, and topical 5-fluorouracil (5-FU) are commonly used to prevent the development of actinic keratosis [1].
• Systemic therapy: Etretinate and isotretinoin have been shown to reduce scaling, discomfort, and disfigurement associated with skin diseases [3][6]. However, these medications may cause skin reactions, which require discontinuation and alternative treatment.
• Transdermal administration: This method of medication delivery has gained popularity in treating skin diseases, offering a more targeted approach compared to oral or systemic treatments [4].
• Topical therapies: Hydroquinone, retinoids, azelaic acid, and other topical agents may be helpful in managing symptoms of obsolete skin abnormalities. Chemical peels and laser therapy can also be effective in some cases [10].

Important Considerations

When treating obsolete skin abnormalities, it is essential to consider the potential side effects of medications. If a medication causes a skin reaction, it should be discontinued immediately, and alternative treatments should be explored.

• Discontinuation: If a medication is causing a skin reaction, it should be stopped to prevent further complications [2][5].
• Alternative treatment: Treatment may include isolation to prevent infection, ointments, and protective measures to manage symptoms [2].

References

[1] D Arcuri (2023) - Nicotinamide, acitretin, and topical 5-fluorouracil (5-FU) continue to be used with fidelity in the chemoprevention of actinic keratosis. [2] Various sources (2023-2024) - Discontinuation of medications causing skin reactions and alternative treatment options. [3] T Cheng (2023) - Etretinate and isotretinoin have been shown to reduce scaling, discomfort, and disfigurement associated with skin diseases. [4] T Cheng (2023) - Transdermal administration offers a more targeted approach compared to oral or systemic treatments. [5] Various sources (2022-2024) - Discontinuation of medications causing skin reactions and alternative treatment options. [6] May 9, 2023 - Acitretin and Isotretinoin have been shown to reduce scaling, discomfort, and disfigurement associated with skin diseases. [7] Jul 18, 2022 - Topical ruxolitinib has been approved for the treatment of vitiligo by the FDA. [8] Various sources (2022-2024) - Typical symptoms for both disorders include peeling skin, fever, body aches, and other complications. [9] Cyclosporine is an immunosuppressive drug that acts selectively on T-cells by inhibiting calcineurin phosphorylase. [10] Various sources (2022-2024) - Topical therapies, chemical peels, and laser therapy can be effective in managing symptoms of obsolete skin abnormalities.