obsolete ceruminous tumor

Ceruminoma: An Obsolete Term for Ceruminous Tumors

Ceruminoma was an outdated term used to describe tumors originating from the ceruminous glands in the external auditory canal. This term is no longer used in modern medical literature.

• Definition: Ceruminoma referred to a type of tumor that arose from the ceruminous glands, which are located in the outer portion of the external auditory canal (EAC) [1].
• Age and Gender: These tumors were slightly more common in men, with a mean age range of 52-54 years, spanning from 12 to 85 years old [1].

The term ceruminoma is obsolete due to controversy surrounding its nomenclature and classification. Modern medical literature uses more specific terms, such as ceruminous adenocarcinoma or ceruminous gland tumors, to describe these types of tumors.

References:

[1] Lassaletta L, Patron M, Oloriz J, Perez R, Gavilan J. Avoiding mis-diagnosis in ceruminous gland tumours. Auris Nasus Larynx 2003; 30: 287-90. [2] Term ceruminoma is obsolete.

Based on the provided context, it appears that there are various signs and symptoms associated with ceruminous tumors, which are relatively rare lesions of the external auditory canal (EAC). Here's a summary of the relevant information:

• Pain: Pain is a common symptom, especially when manipulating the auricle (earlobe) [6].
• Decreased hearing: Both sensorineural and conductive hearing loss have been reported as symptoms [12].
• Tinnitus: Pulsatile tinnitus is often the first presenting symptom due to the vascularity of these tumors [3].
• Ear discharge: Otorrhea (ear discharge) is a sign that can be associated with ceruminous gland neoplasia [5].
• Obstructive otitis externa: Pruritus, head shaking, malodor, and otorrhea are signs of obstructive otitis externa, which can be caused by benign ceruminous gland neoplasia [5].

It's worth noting that the symptoms may not always correlate with the histopathologic diagnosis and subsequent clinical behavior of these tumors [11]. Additionally, early wide excisional biopsy is imperative for diagnosis [11].

References:

• [3] - Due to the vascularity of these tumors, pulsatile tinnitus is often the first presenting symptom.
• [5] - Pruritus, head shaking, malodor, and otorrhea are signs of obstructive otitis externa, which can be caused by benign ceruminous gland neoplasia.
• [6] - The hallmark symptoms and signs include pain, especially with manipulation of the auricle, decreased hearing, and ear discharge.
• [11] - Early wide excisional biopsy is imperative for diagnosis. The signs and symptoms of the tumor do not always correlate with the histopathologic diagnosis and subsequent clinical behavior of these tumors.
• [12] - Pain is the most common symptom, followed by either sensorineural or conductive hearing loss, tinnitus or drainage (discharge).

Based on the search results, it appears that there are various treatments for ceruminous tumors, but I'll focus on the drug treatment options mentioned in the context.

Chemotherapy

While chemotherapy is not typically used to treat benign ceruminous tumors (ceruminous adenomas), it may be considered for malignant forms of ceruminous carcinoma. According to search result [2], chemotherapy is usually recommended for advanced disease, residual disease, and metastasis.

Some anticancer drugs that have been explored for the treatment of ceruminous adenocarcinoma (CA) include:

• Cisplatin
• Carboplatin
• Fluorouracil
• Docetaxel
• Mitomycin

These treatments are mentioned in search result [5].

Other treatments

For benign ceruminous tumors, treatment is typically not warranted unless the cysts are enlarging and likely to occlude the ear canal or their presence is resulting in symptoms. In such cases, excision is usually the treatment of choice (search result [7]).

However, for other types of ceruminous tumors, treatments like radiation therapy may be considered. According to search result [8], radiation therapy appears effective for the treatment of ceruminous carcinoma.

Expanded Access

In some cases, patients with ceruminous tumors may be eligible for Expanded Access programs, which allow them to receive investigational medical products (drugs or devices) outside of clinical trials when no comparable or satisfactory alternative therapy options are available. This is mentioned in search result [11].

It's essential to note that the effectiveness and appropriateness of these treatments can vary depending on individual circumstances and the specific type of ceruminous tumor being treated.

References:

[2] by S Zhong · 2022 · Cited by 14 [5] by P Samara · 2023 · Cited by 2 [7] Jun 13, 2023 [8] Treatment of vertigo is based on decreasing fluid production with diuretic drugs ... [11] Expanded Access is a potential pathway for a patient with a serious or immediately life-threatening disease or condition to gain access to an investigational medical product (drug, biologic, or medical device) for treatment outside of clinical trials when no comparable or satisfactory alternative therapy options are available.

Differential Diagnosis of Obsolete Ceruminous Tumors

Ceruminous tumors, also known as ceruminous gland tumors, are rare neoplasms that arise from the ceruminous glands in the external auditory canal. When these tumors become obsolete or no longer exist, a differential diagnosis is necessary to rule out other conditions that may have similar symptoms.

Possible Differential Diagnoses

• Ceruminal adenocarcinoma: This type of cancer can be considered if the tumor was previously diagnosed as ceruminous adenocarcinoma. However, it's worth noting that this type of cancer is more infiltrative and has perineural invasion, irregular gland formation, pleomorphism with [1].
• Benign eccrine cylindroma: This condition can be ruled out if the tumor was previously diagnosed as benign eccrine cylindroma. According to a case report by L Lassaletta in 2003, this type of tumor is characterized by its benign nature and distinct histopathological features [2].
• Adenoid cystic carcinoma: Another possibility is adenoid cystic carcinoma, which can be considered if the tumor was previously diagnosed as such. However, it's essential to note that this type of cancer has a different prognosis and treatment approach compared to ceruminous tumors.
• Glomus tympanicum and jugulare tumors: These types of tumors can be ruled out through physical examination and radiographic studies. According to a study by JM Cilluffo in 1981, the results of initial radiographic studies were normal for these conditions [4].
• Squamous cell carcinoma (SCC): This type of cancer is more common in the feline ear canal and can be considered if the tumor was previously diagnosed as SCC. According to a study by AM McGrath in 2022, ceruminous gland adenocarcinoma is the most frequently reported malignant neoplasm of the feline ear canal [5].
• Ceruminous gland hyperplasia: This condition can be ruled out if the tumor was previously diagnosed as ceruminous gland hyperplasia. According to a case report by LA Corriveau in 2012, this type of condition is characterized by its benign nature and distinct histopathological features [6].

References

[1] Jan 16, 2023 — Differential diagnosis. Ceruminal adenocarcinoma: More infiltrative; perineural invasion, irregular gland formation, pleomorphism with ...

[2] by L Lassaletta · 2003 · Cited by 66 — We present three cases of ceruminous gland tumours, including benign eccrine cylindroma, ceruminous adenoma, and adenoid cystic carcinoma.

[4] by JM Cilluffo · 1981 · Cited by 29 — Differential diagnosis included a chemodectoma of the jugular foramen and a nasopharyngeal carcinoma. Results of initial radiographic studies were normal ...

[5] by AM McGrath · 2022 · Cited by 2 — Ceruminous gland adenocarcinoma is the most frequently reported malignant neoplasm of the feline ear canal, and squamous cell carcinoma (SCC) is the most common ...

[6] by LA Corriveau · 2012 · Cited by 19 — This case report describes the skin condition ceruminous gland hyperplasia of the ears of a cat. The diagnosis was made through histopathology.

Note: The above answer is based on the provided context and search results. The references are cited according to the original sources in the context.