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rucaparib

CHEBI:CHEBI_134689

Definition

A member of the class of azepinoindoles that is 1,3,4,5-tetrahydro-6H-azepino[5,4,3-cd]indol-6-one carrying additional 4-[(methylamino)methyl]phenyl and fluoro substituents at positions 2 and 8 respectively. It is an inhibitor of poly (ADP-ribose) polymerase and is used (as the camsylate salt) as monotherapy for advanced ovarian cancer and deleterious germline or somatic BRCA mutation.

Chemical Information

Molecular Formula
C19H18FN3O
Molecular Mass
323.371
Charge
0
SMILES
CNCC1=CC=C(C=C1)C1=C2CCNC(=O)C3=C2C(N1)=CC(F)=C3
InChI
InChI=1S/C19H18FN3O/c1-21-10-11-2-4-12(5-3-11)18-14-6-7-22-19(24)15-8-13(20)9-16(23-18)17(14)15/h2-5,8-9,21,23H,6-7,10H2,1H3,(H,22,24)
InChIKey
HMABYWSNWIZPAG-UHFFFAOYSA-N

Alternative Names

  • 8-fluoro-2-{4-[(methylamino)methyl]phenyl}-1,3,4,5-tetrahydro-6H-azepino[5,4,3-cd]indol-6-one
  • AG-14447
  • rucaparib
  • rucaparibum

Treatment Applications

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

DRON_00010000
1862579
oboInOwl#hasDbXref
Wikipedia:Rucaparib
core#notation
CHEBI:134689

Additional References

Wikipedia:Rucaparib

🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.

Additional Attributes

has_treatment
http://purl.obolibrary.org/obo/DOID_3114
oboInOwl#hasOBONamespace
chebi_ontology
DRON_00010000
1862579
oboInOwl#hasDbXref
Wikipedia:Rucaparib
oboInOwl#id
CHEBI:134689
oboInOwl#hasAlternativeId
CHEBI:94311
generic_name
Rucaparib camsylate
product_type
BULK INGREDIENT
marketing_category
BULK INGREDIENT
dosage_form
POWDER
marketing_start_date
20210130
labeler_name
Clovis Oncology, Inc.
product_ndc
66499-0064
brand_name
Rubraca
brand_name_base
Rubraca
application_number
NDA209115
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_62913
oboInOwl#inSubset
http://purl.obolibrary.org/obo/chebi#3_STAR
chebi#is_conjugate_base_of
http://purl.obolibrary.org/obo/CHEBI_134695
core#notation
CHEBI:134689
rxcui
1921589
listing_expiration_date
20241231
route
ORAL
active_ingredient_strength
1 kg/kg
package_marketing_start_date
30-JAN-21
pharm_class
Poly(ADP-Ribose) Polymerase Inhibitors [MoA]
active_ingredient_name
RUCAPARIB CAMSYLATE
spl_id
b977d053-a9f3-e819-e053-2a95a90a8b4e
package_ndc
66499-0064-1
package_description
50 kg in 1 DRUM (66499-0064-1)
manufacturer_name
Clovis Oncology, Inc.
unii
41AX9SJ8KO
spl_set_id
0295d202-1cfe-7659-e063-6294a90a476e
upc
0369660203917
22-rdf-syntax-ns#type
http://www.w3.org/2002/07/owl#Class
rdf-schema#range
https://w3id.org/def/predibionto#has_drug_113017
rdf-schema#domain
https://w3id.org/def/predibionto#has_side_effect2150
chebi#is_conjugate_acid_of
http://purl.obolibrary.org/obo/CHEBI_134695
owl#annotatedSource
t100714
owl#someValuesFrom
t3077803