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rucaparib

CHEBI:CHEBI_134689

Definition

A member of the class of azepinoindoles that is 1,3,4,5-tetrahydro-6H-azepino[5,4,3-cd]indol-6-one carrying additional 4-[(methylamino)methyl]phenyl and fluoro substituents at positions 2 and 8 respectively. It is an inhibitor of poly (ADP-ribose) polymerase and is used (as the camsylate salt) as monotherapy for advanced ovarian cancer and deleterious germline or somatic BRCA mutation.

Chemical Information

Molecular Formula
C19H18FN3O
Molecular Mass
323.371
Charge
0
SMILES
CNCC1=CC=C(C=C1)C1=C2CCNC(=O)C3=C2C(N1)=CC(F)=C3
InChI
InChI=1S/C19H18FN3O/c1-21-10-11-2-4-12(5-3-11)18-14-6-7-22-19(24)15-8-13(20)9-16(23-18)17(14)15/h2-5,8-9,21,23H,6-7,10H2,1H3,(H,22,24)
InChIKey
HMABYWSNWIZPAG-UHFFFAOYSA-N

Alternative Names

  • 8-fluoro-2-{4-[(methylamino)methyl]phenyl}-1,3,4,5-tetrahydro-6H-azepino[5,4,3-cd]indol-6-one
  • AG-14447
  • rucaparib
  • rucaparibum

Treatment Applications

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

DRON_00010000
1862579
oboInOwl#hasDbXref
Wikipedia:Rucaparib
core#notation
CHEBI:134689

Additional References

Wikipedia:Rucaparib

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Additional Attributes

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1862579
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Wikipedia:Rucaparib
oboInOwl#id
CHEBI:134689
core#notation
CHEBI:134689
oboInOwl#hasAlternativeId
CHEBI:94311
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_62913
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chebi#is_conjugate_base_of
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