Discuss This Drug

dabrafenib

CHEBI:CHEBI_75045

Definition

An organofluorine compound and antineoplastic agent, used as its mesylate salt in treatment of metastatic melanoma.

Chemical Information

Molecular Formula
C23H20F3N5O2S2
Molecular Mass
519.56200
Charge
0
SMILES
CC(C)(C)c1nc(-c2cccc(NS(=O)(=O)c3c(F)cccc3F)c2F)c(s1)-c1ccnc(N)n1
InChI
InChI=1S/C23H20F3N5O2S2/c1-23(2,3)21-30-18(19(34-21)16-10-11-28-22(27)29-16)12-6-4-9-15(17(12)26)31-35(32,33)20-13(24)7-5-8-14(20)25/h4-11,31H,1-3H3,(H2,27,28,29)
InChIKey
BFSMGDJOXZAERB-UHFFFAOYSA-N

Alternative Names

  • dabrafenib
  • N-{3-[5-(2-aminopyrimidin-4-yl)-2-tert-butyl-1,3-thiazol-4-yl]-2-fluorophenyl}-2,6-difluorobenzenesulfonamide

Treatment Applications

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

DRON_00010000
1424911
oboInOwl#hasDbXref
Wikipedia:Dabrafenib
core#notation
CHEBI:75045

Additional References

Wikipedia:Dabrafenib

🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.

Additional Attributes

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chebi_ontology
DRON_00010000
1424911
oboInOwl#hasDbXref
Wikipedia:Dabrafenib
oboInOwl#id
CHEBI:75045
generic_name
Dabrafenib mesylate
product_type
BULK INGREDIENT
marketing_category
BULK INGREDIENT
listing_expiration_date
20241231
route
ORAL
dosage_form
TABLET, FOR SUSPENSION
marketing_start_date
20230316
labeler_name
Siegfried Barbera, SL
brand_name
Tafinlar
brand_name_base
Tafinlar
product_ndc
17088-0212
application_number
NDA217514
spl_id
ffa7cd8a-b439-491d-b51a-f4e4b8cea551
package_ndc
17088-0212-1
package_description
25000 TABLET, FOR SUSPENSION in 1 DRUM (17088-0212-1)
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_75047
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core#notation
CHEBI:75045
rxcui
2632556
active_ingredient_strength
10 kg/10kg
package_marketing_start_date
16-MAR-23
pharm_class
Organic Anion Transporting Polypeptide 1B3 Inhibitors [MoA]
manufacturer_name
Novartis Pharmaceuticals Corporation
active_ingredient_name
DABRAFENIB MESYLATE
unii
B6DC89I63E
spl_set_id
fee1e6b1-e1a5-4254-9f2e-a70e0f8dbdea
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