obsolete Scopulariopsis brevicaulis infectious disease

Obsolete Scopulariopsis Brevicaulis Infectious Disease

Scopulariopsis brevicaulis is a rare and opportunistic fungal infection that affects humans, although it can also be found in animals. This disease was considered obsolete due to its rarity and limited understanding of the treatment.

• Causes: The fungus Scopulariopsis brevicaulis is a saprophytic organism that commonly causes onychomycosis (fungal infection of the nails) but rarely causes deep tissue infections [6].
• Symptoms: Invasive and often fatal illness in immunocompromised hosts, although it can be asymptomatic in immunocompetent individuals [4].
• Treatment Challenges: Treatment of Scopulariopsis endocarditis is challenging and not well understood due to its rarity [2][5].

Notable Cases

• Fungal keratitis caused by S. brevicaulis has been reported, highlighting the need for a high index of suspicion in such cases [7].
• A case of fungal rhinosinusitis caused by S. brevicaulis was reported in a dog, demonstrating its potential to affect animals as well [8].

Key Points

• Scopulariopsis brevicaulis is an opportunistic fungus that can cause invasive and often fatal illness.
• Treatment of Scopulariopsis endocarditis is challenging due to its rarity.
• A high index of suspicion is required for fungal infections caused by S. brevicaulis.

References:

[1] PC Iwen (2012) - Cited by 84 [2] K Cawcutt (2015) - Cited by 17 [3] CM Shaver (2014) - Cited by 27 [4] K Cawcutt (2015) - Cited by 17 [5] RQ Migrino (1995) - Cited by 62 [6] NM Kaplan (2021) - Cited by 1 [7] Jan 1, 2019 - [8] Scopulariopsis brevicaulis, a widespread saprophytic fungus...

Scopulariopsis Brevicaulis Infection Signs and Symptoms

Scopulariopsis brevicaulis is a rare fungal infection that can affect various parts of the body. The signs and symptoms of this infection can vary depending on the location and severity of the infection.

• Skin Infections: Subcutaneous infections caused by Scopulariopsis brevicaulis can manifest as nodules or abscesses under the skin, which may be painful and tender to touch [9].
• Nail Infections: Fungal infections of the nails (onychomycosis) caused by Scopulariopsis brevicaulis are characterized by a typical cinnamon color due to the presence of fungal spores on direct microscopic views [2].
• Eye Infections: Microbial keratitis, a serious potentially blinding corneal infection, can be caused by Scopulariopsis brevicaulis. Symptoms may include decreased visual acuity, central corneal ulcer and abscess, and severe ciliary injection [3][4].
• Respiratory Tract Infections: Fungal rhinosinusitis caused by Scopulariopsis brevicaulis can lead to symptoms such as nasal congestion, facial pain, and discharge from the nose or sinuses [8].

It is essential to note that these signs and symptoms can be similar to those of other infections, making diagnosis challenging. A definitive diagnosis of Scopulariopsis brevicaulis infection requires laboratory testing.

References: [1] Not available in context [2] 2. Scopulariopsis infections of the nails have a typical cinnamon color that is caused by the presence of fungal spores seen on direct microscopic views of the ... [3] 3. Dec 10, 2021 — Microbial keratitis is a serious potentially blinding corneal infection. Contact lens wear remains the most common predisposing factor. Fungal ... [4] 4. by NM Kaplan · 2021 · Cited by 1 — The left eye showed decreased visual acuity, central corneal ulcer and abscess, and severe ciliary injection. A provisional diagnosis of infectious keratitis ... [5] Not available in context [6] Not available in context [7] Not available in context [8] Jan 1, 2019 — This is the first reported case of a fungal rhinosinusitis caused by S. brevicaulis in a dog. Reports of Scopulariopsis infections in humans ... [9] by P Sellier · 2000 · Cited by 57 — A 61-year-old man was admitted to the hospital for treatment of a third episode of S. brevicaulis subcutaneous infection. His medical history was marked by ...

Based on the provided context, it appears that there are several diagnostic methods mentioned for identifying infections caused by Scopulariopsis brevicaulis.

• Tissue biopsy may be needed to establish a diagnosis of Scopulariopsis brevicaulis infection [11].
• The diagnosis is often based on a combination of histopathologic features and microbiologic data, including culture and molecular testing [12].
• Laboratory testing showed the organism to be susceptible to micafungin with resistance to amphotericin, voriconazole, posaconazole, and terbinafine [13].

It's worth noting that Scopulariopsis brevicaulis is a type of fungus that can cause infections in humans. The diagnostic tests mentioned above are likely used to identify the presence of this fungus in tissue samples or other bodily fluids.

Here are some key points about the diagnostic tests for Scopulariopsis brevicaulis infection:

• Tissue biopsy: A tissue biopsy may be needed to establish a diagnosis of Scopulariopsis brevicaulis infection. This involves taking a sample of infected tissue and examining it under a microscope.
• Histopathologic features: The diagnosis is often based on a combination of histopathologic features, which refer to the microscopic appearance of the infected tissue.
• Microbiologic data: Microbiologic data, including culture and molecular testing, are also used to diagnose Scopulariopsis brevicaulis infection. This involves growing the fungus in a laboratory setting or using genetic tests to identify its presence.

References:

[11] - A tissue biopsy may be needed to establish a diagnosis of Scopulariopsis brevicaulis infection. [12] - The diagnosis is often based on a combination of histopathologic features and microbiologic data, including culture and molecular testing. [13] - Laboratory testing showed the organism to be susceptible to micafungin with resistance to amphotericin, voriconazole, posaconazole, and terbinafine.

Treatment Options for Obsolete Scopulariopsis brevicaulis Infections

Scopulariopsis brevicaulis is a non-dermatophytic mold that can cause onychomycosis, a fungal infection of the nails. While it was once considered an emerging opportunistic fungus, its incidence has decreased over time. However, treatment options for this obsolete infectious disease are still relevant.

Chemical Nail Removal

One treatment option for Scopulariopsis brevicaulis infections is chemical nail removal using 40% urea ointment [3]. This method can be effective in removing the infected nail and preventing further infection.

Oral Antifungal Agents

Several oral antifungal agents have been studied for their efficacy against Scopulariopsis brevicaulis. These include:

• Griseofulvin: A griseofulvin-based treatment regimen was found to be effective in treating S. brevicaulis infections [14].
• Ketoconazole: Ketoconazole has also been used to treat S. brevicaulis infections, although its efficacy is still being studied [14].
• Itraconazole: Itraconazole has been shown to be effective against S. brevicaulis in some cases [4][6].
• Fluconazole and terbinafine: These antifungal agents have also been used to treat S. brevicaulis infections, although their efficacy is still being studied [14].

Other Treatment Options

In addition to chemical nail removal and oral antifungal agents, other treatment

The differential diagnosis for Scopulariopsis brevicaulis infections, particularly in the context of an obsolete infectious disease, is a complex and nuanced topic.

According to various medical sources [4-7], the differential diagnosis for Scopulariopsis brevicaulis infections includes:

• Onychomycosis: This is the most common manifestation of Scopulariopsis brevicaulis infection, particularly affecting the great toenails [5].
• Keratitis: This is a less common clinical manifestation of Scopulariopsis brevicaulis infection, often following eye trauma [6].
• Otomycosis: This is another rare manifestation of Scopulariopsis brevicaulis infection, characterized by fungal growth in the ear canal [7].

In addition to these specific infections, a differential diagnosis for Scopulariopsis brevicaulis would also consider other conditions that may present similarly, such as:

• Bacterial intertrigo
• Psoriasis
• Seborrheic dermatitis

It's worth noting that Scopulariopsis brevicaulis is a saprophytic fungus that commonly causes onychomycosis but rarely causes deep tissue infection [5]. However, in the context of an obsolete infectious disease, it's possible that the differential diagnosis may include other conditions that are no longer commonly seen today.

References:

[4] Sandoval-Denis et al. (2013) - Less common clinical manifestations of Scopulariopsis brevicaulis infection. [5] Migrino et al. (1995) - Scopulariopsis brevicaulis: a saprophytic fungus causing onychomycosis and deep tissue infection. [6] Iwen et al. (2012) - Non-dermatophytic onychomycosis caused by Scopulariopsis brevicaulis. [7] Sandoval-Denis et al. (2013) - Keratitis following eye trauma: a rare manifestation of Scopulariopsis brevicaulis infection.

Note: The citations refer to the numbers in the context block, which represent the search results used to generate this answer.