obsolete regional neuroblastoma

Neuroblastoma Staging Systems

There have been two primary staging systems used to classify neuroblastoma, an embryonal tumor that affects children under the age of 5.

• International Neuroblastoma Staging System (INSS): This system was widely used until recently. It classified neuroblastoma into four

Based on the provided context, it appears that there are limited resources available for obsolete regional neuroblastoma. However, I can provide some general information on the topic.

Neuroblastoma in Different Regions

• Abdomen (Belly): One of the most common signs of a neuroblastoma is a large lump or swelling in the child’s abdomen [1]. The child might not want to eat (which could be due to abdominal pain) [3].
• Pelvis: A tumor in the pelvis can cause similar symptoms, including a mass under the skin that isn't tender when touched [4].

**Symptoms of

Based on the provided context, it appears that there are several diagnostic tests that were used in the past to diagnose neuroblastoma, particularly in the context of regional or obsolete practices.

Historical Diagnostic Criteria

According to search result [5], essential diagnostic criteria for neuroblastoma included an embryonal tumor with foci of neuroblastic or neuronal differentiation and the activation of FOXR2 by structural changes. However, it's worth noting that these criteria may have been superseded by more modern diagnostic methods.

Immunohistochemistry

Search result [6] mentions immunohistochemistry as a tool for diagnosing neuroblastoma, specifically highlighting the use of monoclonal antibodies to recognize neuroblastoma cells. This technique was likely used in conjunction with other diagnostic methods to confirm the presence of neuroblastoma.

FISH and Other Genetic Tests

Search result [9] notes that FISH (Fluorescence In Situ Hybridization), MLPA (Methylation-Sensitive PCR), and aCGH (Array Comparative Genomic Hybridization) were used in the past for neuroblastoma diagnosis. These techniques provided information on copy number changes, but may not have been as comprehensive or accurate as modern diagnostic methods.

Other Diagnostic Tests

Search result [10] mentions that if neuroblastoma was diagnosed, lab tests could help determine how quickly the tumor might grow or spread, as well as which treatments might work best. Some of these tests included bone marrow aspiration and biopsy, which were used to detect whether the cancer had spread to the bone marrow.

Modern Diagnostic Practices

It's essential to note that these diagnostic tests may be considered obsolete in modern medical practice. The most recent search result [15] suggests that physical exams, imaging studies, and other modern diagnostic methods are now used to diagnose neuroblastoma.

In summary, while there were several diagnostic tests used in the past to diagnose neuroblastoma, many of these methods have been superseded by more modern and accurate techniques.

References:

[5] Essential diagnostic criteria for neuroblastoma [6] Immunohistochemistry as a tool for diagnosing neuroblastoma [9] FISH, MLPA, and aCGH in neuroblastoma diagnosis [10] Lab tests to determine tumor growth or spread [15] Modern diagnostic practices for neuroblastoma

Based on the context, it seems you're looking for information on the drug treatment of a specific type of neuroblastoma that was once considered regional but is now considered obsolete.

Unfortunately, I couldn't find any specific information on this topic in the search results. However, I can try to provide some general information on neuroblastoma and its treatment.

Neuroblastoma is a

Differential diagnosis of obsolete regional neuroblastoma

Obsolete regional neuroblastoma refers to a type of cancer that originates from the adrenal glands or sympathetic nervous system, but has become inactive and no longer grows or spreads. The differential diagnosis for this condition involves identifying other possible causes of symptoms and signs that may mimic those of neuroblastoma.

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