Discuss This Drug

amphotericin B liposomal

CHEBI:CHEBI_2682

Definition

A macrolide antibiotic used to treat potentially life-threatening fungal infections.

Chemical Information

Molecular Formula
C47H73NO17
Molecular Mass
924.07900
Charge
0
SMILES
[H][C@]12C[C@@H](O[C@@H]3O[C@H](C)[C@@H](O)[C@H](N)[C@@H]3O)\C=C\C=C\C=C\C=C\C=C\C=C\C=C\[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@H](O)C[C@](O)(C[C@H](O)[C@H]1C(O)=O)O2
InChI
InChI=1S/C47H73NO17/c1-27-17-15-13-11-9-7-5-6-8-10-12-14-16-18-34(64-46-44(58)41(48)43(57)30(4)63-46)24-38-40(45(59)60)37(54)26-47(61,65-38)25-33(51)22-36(53)35(52)20-19-31(49)21-32(50)23-39(55)62-29(3)28(2)42(27)56/h5-18,27-38,40-44,46,49-54,56-58,61H,19-26,48H2,1-4H3,(H,59,60)/b6-5+,9-7+,10-8+,13-11+,14-12+,17-15+,18-16+/t27-,28-,29-,30+,31+,32+,33-,34-,35+,36+,37-,38-,40+,41-,42+,43+,44-,46-,47+/m0/s1
InChIKey
APKFDSVGJQXUKY-INPOYWNPSA-N

Alternative Names

  • amfotericina B
  • AMPH-B
  • amphotericin B
  • amphotericine B
  • Amphotericine B
  • amphotericinum B
  • Liposomal Amphotericin B
  • (1R,3S,5R,6R,9R,11R,15S,16R,17R,18S,19E,21E,23E,25E,27E,29E,31E,33R,35S,36R,37S)-33-[(3-amino-3,6-dideoxy-beta-D-mannopyranosyl)oxy]-1,3,5,6,9,11,17,37-octahydroxy-15,16,18-trimethyl-13-oxo-14,39-dioxabicyclo[33.3.1]nonatriaconta-19,21,23,25,27,29,31-heptaene-36-carboxylic acid

Treatment Applications

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

core#notation
CHEBI:2682
DRON_00010000
732
oboInOwl#hasDbXref
Wikipedia:Amphotericin_B

Additional References

Wikipedia:Amphotericin_B

🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.

Additional Attributes

core#notation
CHEBI:2682
rxcui
984082
active_ingredient_strength
50 mg/12.5mL
manufacturer_name
Eugia US LLC
package_marketing_start_date
19970811
nui
N0000175510
pharm_class_epc
Lipid-based Polyene Antifungal [EPC]
pharm_class
Lipid-based Polyene Antifungal [EPC]
pharm_class_cs
Polyenes [CS]
active_ingredient_name
DIMYRISTOYLPHOSPHATIDYLGLYCEROL, DL-
unii
BI71WT9P3R
spl_set_id
f7be6506-4d20-401e-a0ff-02ad7c33158a
upc
0362756233010
package_description
1 kg in 1 CONTAINER (45932-0008-2)
22-rdf-syntax-ns#type
http://www.w3.org/2002/07/owl#Class
oboInOwl#hasOBONamespace
chebi_ontology
DRON_00010000
732
generic_name
amphotericin b
brand_name
AmBisome
brand_name_base
AmBisome
oboInOwl#hasDbXref
Wikipedia:Amphotericin_B
oboInOwl#hasAlternativeId
CHEBI:566395
oboInOwl#id
CHEBI:2682
product_type
BULK INGREDIENT
marketing_category
BULK INGREDIENT FOR HUMAN PRESCRIPTION COMPOUNDING
dosage_form
INJECTABLE, LIPOSOMAL
labeler_name
Synbiotics Limited
product_ndc
65044-7183
application_number
NDA050740
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_76969
oboInOwl#inSubset
http://purl.obolibrary.org/obo/chebi#3_STAR
listing_expiration_date
20241231
marketing_start_date
19970811
route
INTRAVENOUS
spl_id
c69015ba-936d-5055-e053-2995a90ab8c9
package_ndc
65044-7183-1
has_treatment
http://purl.obolibrary.org/obo/DOID_0050277
rdf-schema#range
https://w3id.org/def/predibionto#has_drug_113730
owl#annotatedSource
t155467
owl#someValuesFrom
t3006384