Discuss This Drug

enalaprilat (anhydrous)

CHEBI:CHEBI_4786

Definition

Enalapril in which the ethyl ester group has been hydrolysed to the corresponding carboxylic acid. Enalaprilat is an angiotensin-converting enzyme (ACE) inhibitor and is used (often in the form of its prodrug, enalapril) in the treatment of hypertension and heart failure, for reduction of proteinuria and renal disease in patients with nephropathies, and for the prevention of stroke, myocardial infarction, and cardiac death in high-risk patients. Unlike enalapril, enalaprilat is not absorbed by mouth but is given by intravenous injection, usually as the dihydrate.

Chemical Information

Molecular Formula
C18H24N2O5
Molecular Mass
348.39360
Charge
0
SMILES
C[C@H](N[C@@H](CCc1ccccc1)C(O)=O)C(=O)N1CCC[C@H]1C(O)=O
InChI
InChI=1S/C18H24N2O5/c1-12(16(21)20-11-5-8-15(20)18(24)25)19-14(17(22)23)10-9-13-6-3-2-4-7-13/h2-4,6-7,12,14-15,19H,5,8-11H2,1H3,(H,22,23)(H,24,25)/t12-,14-,15-/m0/s1
InChIKey
LZFZMUMEGBBDTC-QEJZJMRPSA-N

Alternative Names

  • enalapril acid
  • enalapril diacid
  • enalaprilat
  • Enalaprilat
  • enalaprilat anhydrous
  • enalaprilate
  • enalaprilatum
  • N-[(1S)-1-carboxy-3-phenylpropyl]-L-alanyl-L-proline

Treatment Applications

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

oboInOwl#hasDbXref
PDBeChem:EAL
core#notation
CHEBI:4786

Additional References

🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.

Additional Attributes

oboInOwl#hasOBONamespace
chebi_ontology
oboInOwl#hasDbXref
PDBeChem:EAL
oboInOwl#hasAlternativeId
CHEBI:123355
oboInOwl#id
CHEBI:4786
core#notation
CHEBI:4786
oboInOwl#inSubset
http://purl.obolibrary.org/obo/chebi#3_STAR
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_35457
22-rdf-syntax-ns#type
http://www.w3.org/2002/07/owl#Class
rdf-schema#range
https://w3id.org/def/predibionto#has_drug_111117
BFO_0000051
http://purl.obolibrary.org/obo/CHEBI_59877
chebi#has_functional_parent
http://purl.obolibrary.org/obo/CHEBI_4784
owl#annotatedSource
t228328
owl#someValuesFrom
t255303