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gefitinib

CHEBI:CHEBI_49668

Definition

A member of the class of quinazolines that is quinazoline which is substituted by a (3-chloro-4-fluorophenyl)nitrilo group, 3-(morpholin-4-yl)propoxy group and a methoxy group at positions 4,6 and 7, respectively. An EGFR kinase inhibitor used for the treatment of non-small cell lung cancer.

Chemical Information

Molecular Formula
C22H24ClFN4O3
Molecular Mass
446.910
Charge
0
SMILES
C1=C(C(=CC=2C1=NC=NC2NC3=CC(=C(C=C3)F)Cl)OCCCN4CCOCC4)OC
InChI
InChI=1S/C22H24ClFN4O3/c1-29-20-13-19-16(12-21(20)31-8-2-5-28-6-9-30-10-7-28)22(26-14-25-19)27-15-3-4-18(24)17(23)11-15/h3-4,11-14H,2,5-10H2,1H3,(H,25,26,27)
InChIKey
XGALLCVXEZPNRQ-UHFFFAOYSA-N

Alternative Names

  • 4-(3'-chloro-4'-fluoroanilino)-7-methoxy-6-(3-morpholinopropoxy)quinazoline
  • gefitinib
  • gefitinibum
  • Iressa
  • Irressat
  • N-(3-chloro-4-fluorophenyl)-7-methoxy-6-(3-(4-morpholinyl)propoxy)-4-quinazolinamine
  • N-(3-chloro-4-fluorophenyl)-7-methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4-amine
  • ZD 1839
  • ZD-1839
  • ZD1839

Treatment Applications

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

DRON_00010000
328134
oboInOwl#hasDbXref
Wikipedia:Gefitinib
core#notation
CHEBI:49668

Additional References

Wikipedia:Gefitinib

🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.

Additional Attributes

oboInOwl#hasOBONamespace
chebi_ontology
DRON_00010000
328134
oboInOwl#hasDbXref
Wikipedia:Gefitinib
oboInOwl#hasAlternativeId
CHEBI:49667
oboInOwl#id
CHEBI:49668
core#notation
CHEBI:49668
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_74440
oboInOwl#inSubset
http://purl.obolibrary.org/obo/chebi#3_STAR
22-rdf-syntax-ns#type
http://www.w3.org/2002/07/owl#Class
rdf-schema#range
https://w3id.org/def/predibionto#has_drug_112718
has_treatment
http://purl.obolibrary.org/obo/DOID_6313
rdf-schema#domain
https://w3id.org/def/predibionto#has_side_effect26641
owl#annotatedSource
t235247
owl#someValuesFrom
t856491