Discuss This Drug

gefitinib

CHEBI:CHEBI_49668

Definition

A member of the class of quinazolines that is quinazoline which is substituted by a (3-chloro-4-fluorophenyl)nitrilo group, 3-(morpholin-4-yl)propoxy group and a methoxy group at positions 4,6 and 7, respectively. An EGFR kinase inhibitor used for the treatment of non-small cell lung cancer.

Chemical Information

Molecular Formula
C22H24ClFN4O3
Molecular Mass
446.910
Charge
0
SMILES
C1=C(C(=CC=2C1=NC=NC2NC3=CC(=C(C=C3)F)Cl)OCCCN4CCOCC4)OC
InChI
InChI=1S/C22H24ClFN4O3/c1-29-20-13-19-16(12-21(20)31-8-2-5-28-6-9-30-10-7-28)22(26-14-25-19)27-15-3-4-18(24)17(23)11-15/h3-4,11-14H,2,5-10H2,1H3,(H,25,26,27)
InChIKey
XGALLCVXEZPNRQ-UHFFFAOYSA-N

Alternative Names

  • 4-(3'-chloro-4'-fluoroanilino)-7-methoxy-6-(3-morpholinopropoxy)quinazoline
  • gefitinib
  • gefitinibum
  • Iressa
  • Irressat
  • N-(3-chloro-4-fluorophenyl)-7-methoxy-6-(3-(4-morpholinyl)propoxy)-4-quinazolinamine
  • N-(3-chloro-4-fluorophenyl)-7-methoxy-6-(3-morpholin-4-ylpropoxy)quinazolin-4-amine
  • ZD 1839
  • ZD-1839
  • ZD1839

Treatment Applications

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

DRON_00010000
328134
oboInOwl#hasDbXref
Wikipedia:Gefitinib
core#notation
CHEBI:49668

Additional References

Wikipedia:Gefitinib

🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.

Additional Attributes

oboInOwl#hasOBONamespace
chebi_ontology
DRON_00010000
328134
oboInOwl#hasDbXref
Wikipedia:Gefitinib
oboInOwl#hasAlternativeId
CHEBI:49667
oboInOwl#id
CHEBI:49668
product_type
BULK INGREDIENT
marketing_category
BULK INGREDIENT FOR HUMAN PRESCRIPTION COMPOUNDING
dosage_form
TABLET, COATED
marketing_start_date
20150514
labeler_name
Nipro Pharma Corporation
generic_name
gefitinib tablets
brand_name
IRESSA
brand_name_base
IRESSA
product_ndc
63850-8070
application_number
ANDA212827
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_74440
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rdf-schema#range
https://w3id.org/def/predibionto#has_drug_112718
has_treatment
http://purl.obolibrary.org/obo/DOID_6313
rdf-schema#domain
https://w3id.org/def/predibionto#has_side_effect26641
owl#annotatedSource
t235247
owl#someValuesFrom
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core#notation
CHEBI:49668
rxcui
402091
listing_expiration_date
20241231
route
ORAL
active_ingredient_strength
25 kg/25kg
package_marketing_start_date
13-SEP-16
nui
N0000175076
pharm_class_epc
Kinase Inhibitor [EPC]
pharm_class
Protein Kinase Inhibitors [MoA]
pharm_class_moa
Protein Kinase Inhibitors [MoA]
manufacturer_name
Natco Pharma USA LLC
spl_id
f0f45118-bec8-409a-a406-daeb961e3d29
active_ingredient_name
GEFITINIB
package_ndc
63850-8070-0
package_description
1 kg in 1 DRUM (63850-8070-0)
unii
S65743JHBS
spl_set_id
1a3c0ce7-06a1-4e04-9106-14ddb2a866a5
upc
0369339168035
22-rdf-syntax-ns#type
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