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enalaprilat dihydrate

CHEBI:CHEBI_59877

Definition

The dihydrate form of enalaprilat, an angiotensin-converting enzyme (ACE) inhibitor that is used (often in the form of its prodrug, enalapril) in the treatment of hypertension and heart failure, for reduction of proteinuria and renal disease in patients with nephropathies, and for the prevention of stroke, myocardial infarction, and cardiac death in high-risk patients. Unlike enalapril, enalaprilat is not absorbed by mouth but is administered by intravenous injection.

Chemical Information

Molecular Formula
C18H28N2O7
Molecular Mass
384.42410
Charge
0
SMILES
O.O.C[C@H](N[C@@H](CCc1ccccc1)C(O)=O)C(=O)N1CCC[C@H]1C(O)=O
InChI
InChI=1S/C18H24N2O5.2H2O/c1-12(16(21)20-11-5-8-15(20)18(24)25)19-14(17(22)23)10-9-13-6-3-2-4-7-13;;/h2-4,6-7,12,14-15,19H,5,8-11H2,1H3,(H,22,23)(H,24,25);2*1H2/t12-,14-,15-;;/m0../s1
InChIKey
MZYVOFLIPYDBGD-MLZQUWKJSA-N

Alternative Names

  • enalaprilat
  • 1-(N-((S)-1-carboxy-3-phenylpropyl)-L-alanyl)-L-proline dihydrate
  • enalprilat hydrate
  • enalprilate hydrate
  • N-[(1S)-1-carboxy-3-phenylpropyl]-L-alanyl-L-proline--water (1/2)

Treatment Applications

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

oboInOwl#hasDbXref
KEGG:D03769
DRON_00010000
3829
core#notation
CHEBI:59877

Additional References

🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.

Additional Attributes

oboInOwl#hasOBONamespace
chebi_ontology
oboInOwl#hasDbXref
KEGG:D03769
DRON_00010000
3829
oboInOwl#id
CHEBI:59877
core#notation
CHEBI:59877
oboInOwl#inSubset
http://purl.obolibrary.org/obo/chebi#3_STAR
BFO_0000051
http://purl.obolibrary.org/obo/CHEBI_4786
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_35457
BFO_0000053
http://purl.obolibrary.org/obo/DRON_00723853
22-rdf-syntax-ns#type
http://www.w3.org/2002/07/owl#Class
rdf-schema#range
https://w3id.org/def/predibionto#has_drug_113746
owl#annotatedSource
t255665
owl#someValuesFrom
t2916251