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enalaprilat dihydrate

CHEBI:CHEBI_59877

Definition

The dihydrate form of enalaprilat, an angiotensin-converting enzyme (ACE) inhibitor that is used (often in the form of its prodrug, enalapril) in the treatment of hypertension and heart failure, for reduction of proteinuria and renal disease in patients with nephropathies, and for the prevention of stroke, myocardial infarction, and cardiac death in high-risk patients. Unlike enalapril, enalaprilat is not absorbed by mouth but is administered by intravenous injection.

Chemical Information

Molecular Formula
C18H28N2O7
Molecular Mass
384.42410
Charge
0
SMILES
O.O.C[C@H](N[C@@H](CCc1ccccc1)C(O)=O)C(=O)N1CCC[C@H]1C(O)=O
InChI
InChI=1S/C18H24N2O5.2H2O/c1-12(16(21)20-11-5-8-15(20)18(24)25)19-14(17(22)23)10-9-13-6-3-2-4-7-13;;/h2-4,6-7,12,14-15,19H,5,8-11H2,1H3,(H,22,23)(H,24,25);2*1H2/t12-,14-,15-;;/m0../s1
InChIKey
MZYVOFLIPYDBGD-MLZQUWKJSA-N

Alternative Names

  • enalaprilat
  • 1-(N-((S)-1-carboxy-3-phenylpropyl)-L-alanyl)-L-proline dihydrate
  • enalprilat hydrate
  • enalprilate hydrate
  • N-[(1S)-1-carboxy-3-phenylpropyl]-L-alanyl-L-proline--water (1/2)

Treatment Applications

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

core#notation
CHEBI:59877
oboInOwl#hasDbXref
KEGG:D03769
DRON_00010000
3829

Additional References

🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.

Additional Attributes

core#notation
CHEBI:59877
oboInOwl#hasOBONamespace
chebi_ontology
oboInOwl#hasDbXref
KEGG:D03769
generic_name
ENALAPRILAT
brand_name
ENALAPRILAT
brand_name_base
ENALAPRILAT
DRON_00010000
3829
oboInOwl#id
CHEBI:59877
rxcui
1729205
product_type
BULK INGREDIENT
listing_expiration_date
20241231
marketing_category
BULK INGREDIENT
dosage_form
INJECTION
labeler_name
HF Acquisition Co LLC, DBA HealthFirst
manufacturer_name
HF Acquisition Co LLC, DBA HealthFirst
route
INTRAVENOUS
pharm_class
Decreased Blood Pressure [PE]
marketing_start_date
20081223
package_marketing_start_date
20081223
active_ingredient_strength
1.25 mg/mL
product_ndc
71796-040
application_number
ANDA078687
spl_id
1c4e94bb-0cab-8963-9140-017b528da8f9
active_ingredient_name
ENALAPRILAT DIHYDRATE
package_ndc
71796-040-00
package_description
1 kg in 1 DRUM (71796-040-00)
unii
GV0O7ES0R3
spl_set_id
9d88f915-13dd-5463-e053-2a95a90a09bf
upc
0343598169583
oboInOwl#inSubset
http://purl.obolibrary.org/obo/chebi#3_STAR
BFO_0000051
http://purl.obolibrary.org/obo/CHEBI_4786
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_35457
BFO_0000053
http://purl.obolibrary.org/obo/DRON_00723853
22-rdf-syntax-ns#type
http://www.w3.org/2002/07/owl#Class
rdf-schema#range
https://w3id.org/def/predibionto#has_drug_113746
owl#annotatedSource
t255665
owl#someValuesFrom
t2916251