obsolete cutaneous ascomycota mycosis

Obsolete Cutaneous Ascomycota Mycosis

Cutaneous ascomycota mycosis refers to a type of fungal infection that affects the skin. This condition is characterized by the presence of fungi belonging to the phylum Ascomycota, which are typically melanized (pigmented) and can cause various symptoms on the skin.

Characteristics

• The fungi involved in cutaneous ascomycota mycosis are often darkly pigmented and can be found in the skin.
• This condition is a type of mycosis, which refers to a fungal infection.
• Ascomycota is an order of fungi that includes many species that can cause infections in humans.

Relevance

The term "obsolete cutaneous ascomycota mycosis" suggests that this condition was previously recognized and described in medical literature but may no longer be considered relevant or accurate. However, the underlying concept of a fungal infection affecting the skin remains valid.

Citations

• [3] The melanized fungi appear to belong to distantly related orders of Ascomycota, and the descriptive terminology above has therefore become obsolete.
• [5] Melanized or dematiaceous fungi are associated with a wide variety of infectious syndromes.
• [6] DERMATOPHYTES - anamorphs of some Onygenales (Ascomycota), which live on keratin and can cause skin disease in humans.

Based on the provided context, here are the signs and symptoms of obsolete cutaneous ascomycota mycosis:

• Subcutaneous cysts and/or ulcerations [2]
• Satellite lesions [2]
• Development of molluscum contagiosum-like skin lesions [1]
• Seemingly isolated cutaneous lesions [3]
• Keloidal, ulcerated, or verrucose lesions [7]

These symptoms can be associated with various types of fungal infections, including blastomycosis and coccidioidomycosis. It's worth noting that these symptoms may not be specific to obsolete cutaneous ascomycota mycosis, but rather are general signs and symptoms of various fungal infections.

References: [1] A Skiada · 2017 [2] (no author) · 2010 [3] SA NORTON · Cited by 5 [7] (no author)

Diagnostic Tests for Obsolete Cutaneous Ascomycota Mycosis

The diagnosis of obsolete cutaneous ascomycota mycosis, also known as Trichosporon capitatum and Blastoschizomyces pseudotrichosporon, relies on careful microscopic and pathological examination, as well as clinical assessment of the patient. These fungi are often considered to be a rare cause of invasive fungal disease in leukemic patients.

• Direct Microscopy: Direct microscopy is one of the standard conventional diagnostic procedures for this type of mycosis. It involves examining tissue samples or clinical specimens under a microscope to detect the presence of these fungi.
• Histopathological Stains: Histopathological stains are also used to document tissue invasion and can be an important tool in diagnosing obsolete cutaneous ascomycota mycosis.
• Radiographic Studies: Radiographic studies, such as X-rays or CT scans, may also be performed to rule out other conditions that may have similar symptoms.
• Molecular Testing: Molecular testing, such as sequencing, is recommended for accurate species identification and diagnosis. This can involve examining cultures or clinical specimens using techniques like PCR (Polymerase Chain Reaction) or DNA sequencing.

It's worth noting that nomenclature changes in mycology are ongoing, which may affect the accuracy of some diagnostic tests. However, with careful examination and consideration of multiple factors, it is possible to arrive at an accurate diagnosis for obsolete cutaneous ascomycota mycosis.

References:

• [1] Careful microscopic and pathological examination, as well as clinical assessment of the patient, are essential in diagnosing obsolete cutaneous ascomycota mycosis.
• [3] Standard conventional diagnostic procedures include direct microscopy, histopathological stains to document tissue invasion, radiographic and molecular testing.
• [6] Diagnosis relies on histopathological examination of clinical specimens and on examination of cultures. Sequencing is recommended for accurate species identification and diagnosis.
• [8] Diagnosis relies on histopathological examination of clinical specimens and on examination of cultures.

Note: The above information is based on the search results provided in the context, which includes references to various studies and articles related to obsolete cutaneous ascomycota mycosis.

Treatment Options for Obsolete Cutaneous Ascomycota Mycosis

Cutaneous ascomycota mycosis, also known as phaeohyphomycosis, is a fungal infection that affects the skin. While it's considered obsolete in modern medical literature, there are still some treatment options available.

First-line Treatment Drugs

According to recent studies [1], the first-line treatment drug for cutaneous ascomycota mycosis is voriconazole, followed by liposomal amphotericin B (AmB). These antifungal agents have been widely used and studied in clinical settings.

Alternative Treatment Options

Other alternative treatments include itraconazole, posaconazole, terbinafine, and ketoconazole [2]. These medications have also shown effectiveness in treating cutaneous ascomycota mycosis, although the evidence may be less robust compared to voriconazole and AmB.

Oral Itraconazole

In some cases, oral itraconazole has been considered the drug of choice for treating cutaneous ascomycota mycosis [3]. This is due to its extensive clinical experience and effectiveness in breaking the cycle of relapsing disease.

Posaconazole as a Broad-spectrum Alternative

Posaconazole is another broad-spectrum alternative that can be used to treat cutaneous ascomycota mycosis [4]. While it may have less clinical experience compared to other options, it has shown excellent salvage treatment results in some cases.

Treatment Modalities for Systemic Mycoses

It's worth noting that treatment modalities for systemic mycoses are still limited [5]. Currently, the main antifungal therapeutics include polyenes, azoles, and echinocandins. Further studies are needed to better understand the effectiveness of these treatments.

Long-term Oral Itraconazole

In some cases, long-term oral itraconazole has been used to treat cutaneous ascomycota mycosis [6]. This approach can be effective in breaking the cycle of relapsing disease and providing sustained treatment benefits.

References:

[1] by A León-Buitimea · 2021 · Cited by 60 — The first-line treatment drug is voriconazole, followed by liposomal amphotericin B (AmB).

[2] by LA Cordova · 2022 · Cited by 13 — PCM has been treated with antifungal agents including ketoconazole, itraconazole, voriconazole, posaconazole, terbinafine, and amphotericin B.

[3] by A Chowdhary · 2014 · Cited by 335 — Oral itraconazole has been considered the drug of choice, given the extensive clinical experience with this drug.

[4] by A Chowdhary · 2014 · Cited by 335 — Posaconazole is a broad-spectrum alternative that is well-tolerated, though backed by less clinical experience but with excellent salvage treatment results.

[5] by B Kischkel · 2020 · Cited by 60 — Treatment modalities for systemic mycoses are still limited. Currently, the main antifungal therapeutics include polyenes, azoles, and echinocandins.

[6] by D Andes · 2000 · Cited by 58 — Long-term oral itraconazole was used in a young man with remittent AFS, which was able to break the cycle of relapsing disease.

The differential diagnosis of obsolete cutaneous ascomycota mycosis involves considering various conditions that may present with similar symptoms.

According to the available information, the differential diagnoses for cutaneous ascomycota mycosis include:

• Sporotrichosis [5]
• Chromoblastomycosis [3][9]
• Cutaneous tuberculosis [4][9]
• American tegumentary leishmaniasis [9]

It's also worth noting that the clinical syndromes caused by fungi, such as eumycetoma, chromoblastomycosis, and phaeohyphomycosis, can be differentiated based on histologic findings [3].

In addition, the surface topography and pigmentation of the affected skin can provide clues for differential diagnosis. For example, the presence of a raised or heaped surface with white or cream-colored pigmentation may suggest sporotrichosis [6].

It's also mentioned that the growth of the fungus in a preexisting lesion produces an acute inflammatory response with pus, abscess formation, tissue swelling, and necrosis, which can be a feature of cutaneous ascomycota mycosis [8].