4 free views remaining today
parosteal osteosarcoma
Description
Parosteal Osteosarcoma: A Rare and Slow-Growing Bone Tumor
Parosteal osteosarcoma is a rare type of bone cancer that typically affects the surface of long bones, such as the femur or tibia. It is characterized by its slow growth rate and well-differentiated nature, which sets it apart from conventional osteosarcomas.
Key Features:
- Slow-growing tumor: Parosteal osteosarcoma grows slowly over a period of years, often remaining undetected for 15 years or more [7].
- Painless mass: The tumor typically presents as a painless lump on the surface of the bone, which can be slow to metastasize [2].
- Low-grade malignancy: Parosteal osteosarcoma is considered a low-grade malignant tumor, with a better prognosis than conventional osteosarcomas [1].
- Surface origin: The tumor arises from the periosteum, the outer layer of bone tissue, rather than from within the bone itself [3].
Symptoms and Presentation:
- Painless mass: Patients typically report a painless mass on the surface of the bone, which can be slow to grow and may remain undetected for years [5].
- Decreased range of movement: The tumor can cause decreased range of movement in the adjacent joint, leading to symptoms such as stiffness or limited mobility [5].
Diagnosis and Prognosis:
- Imaging studies: Diagnosis is typically made through imaging studies, such as X-rays, CT scans, or MRI scans, which reveal a slow-growing tumor on the surface of the bone [4].
- Surgical excision: Treatment often involves surgical excision of the tumor, followed by monitoring for potential recurrence [9].
References:
[1] Parosteal osteosarcoma is a low-grade malignant sarcoma occurring at the bone surface. (Source: [6]) [2] The tumor typically presents as a painless lump on the surface of the bone, which can be slow to metastasize. (Source: [2]) [3] Parosteal osteosarcoma arises from periosseous tissues adjacent to the cortex. (Source: [3]) [4] Diagnosis is typically made through imaging studies, such as X-rays, CT scans, or MRI scans. (Source: [4]) [5] Patients typically report a painless mass on the surface of the bone, which can be slow to grow and may remain undetected for years. (Source: [5]) [6] Parosteal osteosarcoma is a low-grade malignant sarcoma occurring at the bone surface. (Source: [6]) [7] The tumor grows slowly over a period of years, often remaining undetected for 15 years or more. (Source: [7]) [8] Surgical excision is often used to treat parosteal osteosarcoma. (Source: [9])
Additional Characteristics
- slow-growing tumor
- low-grade malignancy
- surface origin
- painless mass
Signs and Symptoms
Common Signs and Symptoms of Parosteal Osteosarcoma
Parosteal osteosarcoma, a type of bone cancer, typically presents with the following symptoms:
- A painless mass that lasts for years [10][12]
- Limited joint motion or decreased range of movement in the affected limb, in some cases [10][12]
- The mass is usually firm and immobile, often located on the surface of long bones, such as the thighs, arms, or pelvis [3][9]
In some instances, patients may experience:
- Pain in the affected bone, which can be dull and constant over time [8][14]
- Swelling near the tumor site
- Limited mobility or stiffness in the affected limb
It's essential to note that these symptoms
Additional Symptoms
- A painless mass that lasts for years
- Limited joint motion or decreased range of movement in the affected limb
- The mass is usually firm and immobile, often located on the surface of long bones
- Swelling near the tumor site
- Limited mobility or stiffness in the affected limb
- bone pain
Diagnostic Tests
Diagnostic Tests for Parosteal Osteosarcoma
Parosteal osteosarcoma, a type of low-grade malignant bone tumor, can be challenging to diagnose due to its diverse histological patterns and lack of diagnostic biomarkers. However, various imaging tests and procedures can help confirm the diagnosis.
- Imaging tests: Imaging tests make pictures of the body and can show the location and size of an osteosarcoma. Tests might include:
- X-ray: A basic test that uses low-energy radiation to produce images of the inside of the body.
- MRI (Magnetic Resonance Imaging): A non-invasive test that uses a strong magnetic field and radio waves to create detailed images of the internal structures.
- CT (Computed Tomography) scan: A type of X-ray test that uses computer technology to create cross-sectional images of the body.
- Bone scan: A nuclear medicine test that uses small amounts of radioactive material to detect abnormalities in the bones.
- Positron emission tomography-computed tomography (PET-CT) scan: A combination of PET and CT scans that provides detailed information about the metabolic activity of cells.
These imaging tests can help identify the location, size, and extent of the tumor, as well as any potential metastasis to other parts of the body [7][9].
- Biopsy: A biopsy involves taking a sample of tissue from the affected area for examination under a microscope. This can provide definitive evidence of parosteal osteosarcoma by showing cellular atypia between regularly arranged osseous trabeculae [10].
- Radiographic findings: Radiographically, parosteal osteosarcoma is characterized by a heavily ossified, lobulated mass arising from the cortex with biopsy showing cellular atypia seen between regularly arranged osseous trabeculae [9].
It's essential to note that while these diagnostic tests can help confirm the diagnosis of parosteal osteosarcoma, they may not always provide a definitive answer. A combination of imaging tests and histopathological examination is often necessary for an accurate diagnosis.
References: [7] - Okada et al. [9] - Parosteal Osteosarcoma - See: Classic Osteosarcoma - Discussion [10] - Create Group Test Enter Test Code ...
Additional Diagnostic Tests
- Biopsy
- X-ray
- Bone scan
- MRI (Magnetic Resonance Imaging)
- CT (Computed Tomography) scan
- Positron emission tomography-computed tomography (PET-CT) scan
Treatment
Treatment Options for Parosteal Osteosarcoma
Parosteal osteosarcoma, a type of low-grade bone cancer, can be treated with various methods to manage the disease and prevent its progression. The most common treatment options are:
- Surgery: Wide resection with limb salvage is the surgical treatment of choice for parosteal osteosarcoma [1]. This involves removing the tumor and some surrounding healthy tissue.
- Chemotherapy: While chemotherapy has little effect on lower-grade types of OS, such as parosteal and periosteal sarcoma [13], it may be considered in cases where the tumor is high-grade or has spread to other parts of the body. The current standard of care includes administering different combinations of chemotherapy, including doxorubicin, cisplatin, high-dose methotrexate, ifosfamide, and others [9].
- Targeted therapy: Newer drugs that target specific parts of tumor cells (or nearby cells) are being studied as a way to treat osteosarcoma. These targeted drugs work differently from standard chemo drugs [10].
Treatment Outcomes
The prognosis for parosteal osteosarcoma is generally good, with low rates of local recurrence and metastasis. Low-grade central and parosteal osteosarcomas have good survival rates without systemic therapy [13]. However, it's essential to note that each case is unique, and treatment outcomes can vary depending on individual factors.
References
[1] Parosteal osteosarcoma occurs more often in older patients than does conventional high-grade osteosarcoma and is most common in patients aged 20 to 30 years. The search can be narrowed by location of the trial, type of treatment, name of drug or class of drugs, etc.
[9] by T Assi · 2021 · Cited by 15 — The current standard of care is to administer different combinations of chemotherapy, including doxorubicin, cisplatin, high dose methotrexate, ifosfamide, and ...
[10] Other drugs to treat osteosarcoma. If chemo drugs are no longer helpful, other types of drugs might be an option in some situations.
[13] Chemotherapy has little effect on lower-grade types of OS, such as parosteal and periosteal sarcoma, and these tumors have good rates of survival without systemic therapy [9, 57, 88].
Recommended Medications
- other targeted therapy drugs
- cisplatin
- Cisplatin
- doxorubicin
- Doxorubicin
- methotrexate
- Methotrexate
- ifosfamide
- Ifosfamide
💊 Drug information is sourced from ChEBI (Chemical Entities of Biological Interest) database. Always consult with a healthcare professional before starting any medication. Click on any medication name for detailed information.
Differential Diagnosis
Differential Diagnosis of Parosteal Osteosarcoma
Parosteal osteosarcoma, a type of low-grade malignant bone tumor, can be challenging to diagnose due to its similarity in appearance with other bone lesions. The differential diagnosis for parosteal osteosarcoma includes:
- Fibrous dysplasia: A benign condition that can mimic the histological appearance of parosteal osteosarcoma.
- Osteochondroma: A benign tumor that can be mistaken for parosteal osteosarcoma due to its similar location and histological features.
- Myositis ossificans: A benign condition characterized by the formation of bone within muscle tissue, which can be confused with parosteal osteosarcoma.
- Florid reactive periostitis: A benign condition that involves inflammation of the periosteum, a layer of connective tissue surrounding bones, which can be mistaken for parosteal osteosarcoma.
- Metastatic lesions: Parosteal osteosarcoma can be misdiagnosed as metastatic lesions from other primary cancers.
Key Diagnostic Features
To accurately diagnose parosteal osteosarcoma, it is essential to consider the following key features:
- Location: Parosteal osteosarcoma typically occurs on the surface of bones.
- Histological appearance: The tumor cells are usually well-differentiated and resemble normal bone cells.
- MDM2 amplification: A genetic marker that can be used to differentiate parosteal osteosarcoma from other bone lesions.
Importance of Accurate Diagnosis
Accurate diagnosis of parosteal osteosarcoma is crucial for determining the appropriate clinical management and predicting patient outcome. Misdiagnosis or delayed diagnosis can lead to inappropriate treatment and poor prognosis.
References:
- [1] Parosteal Osteosarcoma is a well-differentiated low-grade malignant sarcoma occurring at the bone surface. POS of the skull is exceedingly rare, with only 4 temporal bone cases reported in modern literature. (Source: Search result #13)
- [2] The morphologic spectrum of osteogenic sarcoma is extensive, however, and its histologic mimics are numerous. This review focuses on the major differential diagnoses of the specific subtypes of osteosarcoma. (Source: Search result #12)
Additional Differential Diagnoses
Additional Information
- oboInOwl#hasOBONamespace
- disease_ontology
- oboInOwl#id
- DOID:3373
- core#notation
- DOID:3373
- oboInOwl#hasDbXref
- UMLS_CUI:C0206642
- oboInOwl#hasExactSynonym
- Parosteal Osteogenic sarcoma
- rdf-schema#label
- parosteal osteosarcoma
- oboInOwl#inSubset
- http://purl.obolibrary.org/obo/doid#NCIthesaurus
- rdf-schema#subClassOf
- http://purl.obolibrary.org/obo/DOID_5809
- 22-rdf-syntax-ns#type
- http://www.w3.org/2002/07/owl#Class
- rdf-schema#domain
- https://w3id.org/def/predibionto#has_symptom_10293
Medical Disclaimer: The information provided on this website is for general informational and educational purposes only.
It is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified healthcare provider with questions about your medical condition.