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angiosarcoma

ICD-10 Codes

Related ICD-10:

Description

What is Angiosarcoma?

Angiosarcoma is a rare and aggressive type of cancer that originates from the endothelial cells lining blood vessels or lymphatic vessels. It is a highly malignant tumor, accounting for only 1-2% of all soft tissue sarcomas.

Characteristics of Angiosarcoma

  • Rare occurrence: Angiosarcoma is an uncommon cancer, making up less than 2% of all soft tissue sarcomas.
  • Aggressive growth: This type of cancer grows rapidly and can spread quickly to other parts of the body.
  • Vascular origin: Angiosarcoma develops from the endothelial cells that line blood vessels or lymphatic vessels.
  • Age and location: While it can occur anywhere in the body, angiosarcoma most often affects older adults, with a higher incidence rate in people over 50.

Symptoms of Angiosarcoma

The symptoms of angiosarcoma may vary depending on the location and stage of the cancer. Some common signs include:

  • A raised area of

Additional Characteristics

  • Characteristics
  • Common_Symptoms
  • Angiosarcoma_Definition

Signs and Symptoms

Common Signs and Symptoms of Angiosarcoma

Angiosarcoma, a rare type of cancer that forms in the lining of blood vessels and lymph vessels, can exhibit various signs and symptoms depending on its location. Here are some common symptoms associated with angiosarcoma:

  • Skin manifestations: A raised, purplish area of skin that resembles a bruise is often seen on the head or neck region (1). This lesion may bleed easily when bumped or scratched and grow larger over time.
  • Painless lump or mass: A painless lump or mass in soft tissue can be a common sign of angiosarcoma, especially if it's located deep within the body (3).
  • Bruised area on the skin: Angiosarcoma can cause a bruised area on the skin that may grow larger and bleed when scratched or bumped (6).
  • Pain near the tumor: Pain near the affected area is another symptom of angiosarcoma, especially if it's located in deep tissue like the liver or heart (5).
  • Fatigue, malaise, and unexplained weight loss: Symptoms like fatigue, malaise, and unexplained weight loss can occur when angiosarcoma affects organs such as the liver or heart (5).

Symptoms vary depending on location

The symptoms of angiosarcoma can differ significantly based on its location in the body. For instance:

  • Skin angiosarcoma: A raised patch that resembles a bruise and may be tender is often seen on the skin, especially on the head or neck region (8).
  • Deep tissue angiosarcoma: Symptoms like fatigue, pain near the affected area, malaise, unexplained weight loss, shortness of breath, jaundice, and persistent pain in the upper left part of the belly can occur when angiosarcoma affects organs such as the liver or heart (5).

Early diagnosis and treatment are crucial

Recognizing the clinical signs and symptoms of angiosarcoma is essential for early diagnosis and effective treatment. Total removal of the affected organ, if possible, may lead to increased chances of recurrence, highlighting the importance of prompt medical attention.

References:

(1) Context reference 1 (3) Context reference 3 (5) Context reference 5 (6) Context reference 6 (8) Context reference 8

Additional Symptoms

Diagnostic Tests

Diagnostic Tests for Angiosarcoma

Angiosarcoma diagnosis involves a combination of physical examination, imaging tests, and laboratory tests to confirm the presence of this rare type of cancer.

  • Physical Exam: A thorough physical examination by a healthcare provider is essential to understand the extent of the disease [1].
  • Imaging Tests: Various imaging tests are used to diagnose angiosarcoma, including:
    • Magnetic Resonance Imaging (MRI): Provides accurate delineation of tumor size and location, especially for extremities, retroperitoneum, or abdominal wall angiosarcomas [2].
    • Computed Tomography (CT) Scan: A CT scan is commonly used to diagnose angiosarcoma, along with other imaging tests like MRI and PET scan [3][4].
    • Positron Emission Tomography (PET) Scan: A PET scan can help identify the tumor's size and location, as well as assess its metabolic activity [5].

Additional Diagnostic Tests

  • Biopsy: A biopsy is performed to confirm a diagnosis of angiosarcoma. This involves taking a sample of the tumor during an image-guided needle biopsy [6].
  • Immunohistochemistry: A lab test called immunohistochemistry can confirm an angiosarcoma diagnosis by analyzing the tumor's cellular structure [7].

References

[1] May 17, 2022 — Tests and procedures used in angiosarcoma diagnosis include: Physical exam. Your health care provider will thoroughly examine you to understand ...

[2] Aug 18, 2022 — For angiosarcoma of the extremities, retroperitoneum, or abdominal wall, magnetic resonance imaging (MRI) provides more accurate delineation of ...

[3] To confirm a diagnosis and gain more information, one of our specialized radiologists will take a sample of the tumor during an image-guided needle biopsy.

[4] A CT scan, MRI and PET scan are the most common tests used to diagnose angiosarcoma. ... A lab test called immunohistochemistry can confirm an angiosarcoma ...

[5] by AM Spiker · 2023 · Cited by 16 — Hence, the initial staging workup includes an MRI of the brain with and without contrast, a CT scan of the chest, and a CT scan of the abdomen and pelvis. Also, ...

[6] Feb 27, 2019 — Imaging: If you have symptoms, your doctor will use imaging scans such as MRI, CT, or PET scan to look at the tumor's size and location. · Biopsy ...

[7] Jan 2, 2022 — You'll likely have several other tests: Imaging tests like an MRI, CT, or PET scan can help pinpoint the location and size of the tumor.

[8] How are angiosarcomas diagnosed? · Blood and urine tests · Ultrasound · Magnetic resonance imaging (MRI

Additional Diagnostic Tests

  • Physical Exam
  • Immunohistochemistry
  • Biopsy
  • Magnetic Resonance Imaging (MRI)
  • Computed Tomography (CT) Scan
  • Positron Emission Tomography (PET) Scan

Treatment

Treatment Options for Angiosarcoma

Angiosarcoma, a rare and aggressive form of cancer, can be challenging to treat. However, various drug treatments have shown promise in managing this condition.

  • Targeted Therapy: Targeted drugs, such as pazopanib and regorafenib, may be an option for advanced angiosarcoma patients [7]. These medications work by inhibiting specific proteins involved in tumor growth.
  • Chemotherapy: Chemotherapy remains a cornerstone in the treatment of angiosarcomas. Drugs like doxorubicin, paclitaxel, and ifosfamide have been used to combat this cancer [4][8].
  • Immunotherapy: Immunotherapy has also shown potential in treating angiosarcoma. A case report demonstrated a sustained response to PD-1 directed therapy in a patient with angiosarcoma that expressed PD-L1 [6].

Recent Developments

Recent studies have explored the effectiveness of combining proton beam therapy with chemotherapy for cardiac angiosarcoma, demonstrating improved outcomes and safety [3]. Additionally, vascular endothelial growth factor (VEGF) inhibitors like pazopanib and regorafenib have been investigated as potential treatments for angiosarcoma [7].

Treatment Considerations

When considering treatment options for angiosarcoma, it's essential to discuss the following with your healthcare provider:

  • The stage and location of the cancer
  • Your overall health and medical history
  • Potential side effects and risks associated with each treatment option

By weighing these factors and consulting with a qualified healthcare professional, patients can make informed decisions about their care.

References: [3] by AM Spiker · 2023 · Cited by 16 — [4] by B Tunstall — [6] by S Sindhu · 2017 · Cited by 126 — [7] by L Guan · 2023 · Cited by 9 — [8] by B Tunstall —

💊 Drug information is sourced from ChEBI (Chemical Entities of Biological Interest) database. Always consult with a healthcare professional before starting any medication. Click on any medication name for detailed information.

Differential Diagnosis

Differential Diagnosis of Angiosarcoma

Angiosarcoma, a rare and aggressive subtype of soft-tissue sarcoma, can be challenging to diagnose due to its nonspecific clinical presentation and histopathologic appearance. The differential diagnosis for angiosarcoma includes various conditions that may present with similar symptoms and imaging findings.

Conditions in the Differential Diagnosis:

  • Haemangioblastoma: A rare, benign tumor of the blood vessels that can occur in the brain or spine.
  • Kaposi sarcoma: A type of cancer that affects the skin and other organs, often associated with HIV/AIDS.
  • Metastatic cancer from an unknown primary site: Cancer that has spread to a new location but originated from an unknown primary source.
  • Sinonasal squamous-cell cancer: A rare type of cancer that occurs in the nasal cavity or sinuses.
  • Atypical fibroxanthoma: A rare, benign tumor of the skin that can mimic angiosarcoma on histopathology.

Imaging and Histopathologic Features:

The differential diagnosis for angiosarcoma also includes conditions with similar imaging and histopathologic features. These include:

  • Myxoma: A type of benign tumor that can occur in the heart or other organs.
  • Thrombus: A blood clot that can form in a vessel or organ.
  • Lymphoma: A type of cancer that affects the immune system.
  • Rhabdomyosarcoma: A rare, malignant tumor of the muscles.

Clinical Presentation:

The clinical presentation of angiosarcoma can vary widely and may include symptoms such as:

  • A rapidly growing mass or lesion
  • Skin changes, such as a bruise-like appearance
  • Swelling or pain in the affected area

Diagnostic Imaging:

Imaging studies, such as ultrasound, CT, and MRI, can be used to help diagnose angiosarcoma. However, these imaging modalities may not always provide a definitive diagnosis.

Final Diagnosis:

The final diagnosis of angiosarcoma requires pathological and immunohistochemical confirmation. A thorough examination of the tumor tissue under a microscope is essential to rule out other conditions in the differential diagnosis.

References:

  • Garcia AR, Ribeiro J, Gervásio H, Sousa FC e. Hepatic Angiosarcoma Masquerading as Hemangioma: A Challenging Differential Diagnosis.
  • Other references from the provided context.

Additional Information

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