Discuss This Drug

exemestane

CHEBI:CHEBI_4953

Definition

A 17-oxo steroid that is androsta-1,4-diene-3,17-dione in which the hydrogens at position 6 are replaced by a double bond to a methylene group. A selective inhibitor of the aromatase (oestrogen synthase) system, it is used in the treatment of advanced breast cancer.

Chemical Information

Molecular Formula
C20H24O2
Molecular Mass
296.40340
Charge
0
SMILES
[H][C@@]12CC(=C)C3=CC(=O)C=C[C@]3(C)[C@@]1([H])CC[C@]1(C)C(=O)CC[C@@]21[H]
InChI
InChI=1S/C20H24O2/c1-12-10-14-15-4-5-18(22)20(15,3)9-7-16(14)19(2)8-6-13(21)11-17(12)19/h6,8,11,14-16H,1,4-5,7,9-10H2,2-3H3/t14-,15-,16-,19+,20-/m0/s1
InChIKey
BFYIZQONLCFLEV-DAELLWKTSA-N

Alternative Names

  • 6-methyleneandrosta-1,4-diene-3,17-dione
  • 6-methylideneandrosta-1,4-diene-3,17-dione
  • exemestane
  • Exemestane
  • exemestano
  • exemestanum

Treatment Applications

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

core#notation
CHEBI:4953
DRON_00010000
258494
oboInOwl#hasDbXref
Wikipedia:Exemestane

Additional References

Wikipedia:Exemestane

🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.

Additional Attributes

has_treatment
http://purl.obolibrary.org/obo/DOID_5310
rdf-schema#domain
https://w3id.org/def/predibionto#has_side_effect26485
owl#annotatedSource
t235270
owl#someValuesFrom
t824303
core#notation
CHEBI:4953
rxcui
261317
active_ingredient_strength
10 kg/10kg
package_marketing_start_date
01-AUG-07
manufacturer_name
Upsher-Smith Laboratories, Inc.
nui
N0000175080
pharm_class_epc
Aromatase Inhibitor [EPC]
pharm_class
Aromatase Inhibitors [MoA]
pharm_class_moa
Aromatase Inhibitors [MoA]
active_ingredient_name
EXEMESTANE
unii
NY22HMQ4BX
spl_set_id
9354d1a1-8e8c-4c6a-b7ad-d4fe14b10a8b
upc
0371921190331
package_description
20 kg in 1 BOX (59057-008-00)
22-rdf-syntax-ns#type
http://www.w3.org/2002/07/owl#Class
oboInOwl#hasOBONamespace
chebi_ontology
DRON_00010000
258494
oboInOwl#hasDbXref
Wikipedia:Exemestane
oboInOwl#id
CHEBI:4953
generic_name
EXEMESTANE
brand_name
Aromasin
brand_name_base
Aromasin
product_type
BULK INGREDIENT
marketing_category
BULK INGREDIENT FOR HUMAN PRESCRIPTION COMPOUNDING
dosage_form
POWDER
labeler_name
Curia Wisconsin, Inc.
product_ndc
49386-026
application_number
ANDA213547
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_50790
oboInOwl#inSubset
http://purl.obolibrary.org/obo/chebi#3_STAR
chebi#has_parent_hydride
http://purl.obolibrary.org/obo/CHEBI_35509
listing_expiration_date
20241231
route
ORAL
marketing_start_date
19991021
spl_id
eaf1169e-fe89-4e83-9124-02f6c36fc7b3
package_ndc
49386-026-01
rdf-schema#range
https://w3id.org/def/predibionto#has_drug_113802