Discuss This Drug

Dacarbazine

CHEBI:CHEBI_4305

Definition

A monocarboxylic acid amide that is 1H-imidazole-4-carboxamide which is substituted at position 5 by a 3,3-dimethyltriaz-1-en-1-yl group. It is used for the treatment of metastatic malignant melanoma, and in combination with other drugs for the treatment of Hodgkin's disease and soft-tissue sarcoma.

Chemical Information

Molecular Formula
C6H10N6O
Molecular Mass
182.183
Charge
0
SMILES
C=1NC(=C(N1)C(=O)N)N=NN(C)C
InChI
InChI=1S/C6H10N6O/c1-12(2)11-10-6-4(5(7)13)8-3-9-6/h3H,1-2H3,(H2,7,13)(H,8,9)
InChIKey
FDKXTQMXEQVLRF-UHFFFAOYSA-N

Alternative Names

  • 4-(3,3-dimethyl-1-triazeno)imidazole-5-carboxamide
  • 4-(5)-(3,3-dimethyl-1-triazeno)imidazole-5(4)-carboxamide
  • 4-(dimethyltriazeno)imidazole-5-carboxamide
  • 5-(3,3-dimethyl-1-triazeno)imidazole-4-carboxamide
  • 5-(3,3-Dimethyl-1-triazeno)imidazole-4-carboxamide
  • 5-(3,3-dimethyltriaz-1-en-1-yl)-1H-imidazole-4-carboxamide
  • 5-(3,3-dimethyltriazeno)imidazole-4-carboxamide
  • 5-(dimethyltriazeno)imidazole-4-carboxamide
  • dacarbazina
  • dacarbazine
  • dacarbazinum
  • deticene
  • Di-me-triazenoimidazolecarboxamide
  • DIC
  • DTIC
  • Dtic-Dome (TN)
  • HSDB 3219
  • ICDMT
  • Imidazole-4-carboxamide, 5-(3,3-dimethyl-1-triazeno)-
  • NCI-C04717
  • NSC 45388
  • NSC-45388

Treatment Applications

Drug Classification

Important Medical Information

⚕️ This information is sourced from ChEBI (Chemical Entities of Biological Interest) database and is intended for educational purposes only.

  • Always consult with a healthcare professional before starting, stopping, or modifying any medication.
  • Side effects may vary and this list may not be comprehensive.
  • Drug interactions may occur with other medications.

Additional Identifiers

DRON_00010000
3098
oboInOwl#hasDbXref
Wikipedia:Dacarbazine
core#notation
CHEBI:4305

Additional References

Wikipedia:Dacarbazine

🔍 Click on any linked disease name to learn more about the conditions this medication is used to treat, or explore related drug classifications for more information about similar medications.

Additional Attributes

oboInOwl#hasOBONamespace
chebi_ontology
DRON_00010000
3098
oboInOwl#hasDbXref
Wikipedia:Dacarbazine
oboInOwl#id
CHEBI:4305
generic_name
DACARBAZINE
brand_name
Dacarbazine
brand_name_base
Dacarbazine
product_type
BULK INGREDIENT
listing_expiration_date
20251231
marketing_category
BULK INGREDIENT
dosage_form
INJECTION, POWDER, FOR SOLUTION
labeler_name
Heraeus Precious Metals GmbH & Co. KG
marketing_start_date
20010808
product_ndc
54875-0003
application_number
ANDA075812
spl_id
0bda6589-3bdb-5678-e063-6294a90ac035
RO_0000087
http://purl.obolibrary.org/obo/CHEBI_22333
oboInOwl#inSubset
http://purl.obolibrary.org/obo/chebi#3_STAR
core#notation
CHEBI:4305
rxcui
1731340
manufacturer_name
Fresenius Kabi USA, LLC
active_ingredient_strength
1 kg/kg
route
INTRAVENOUS
package_marketing_start_date
20010808
pharm_class_moa
Alkylating Activity [MoA]
pharm_class
Alkylating Drug [EPC]
pharm_class_epc
Alkylating Drug [EPC]
nui
N0000175558
active_ingredient_name
DACARBAZINE
package_ndc
54875-0003-1
package_description
1 BOTTLE, PLASTIC in 1 BAG (54875-0003-1) / 2000 g in 1 BOTTLE, PLASTIC
unii
7GR28W0FJI
spl_set_id
0d81315c-7021-4091-b703-ad135390c936
upc
0363323127008
22-rdf-syntax-ns#type
http://www.w3.org/2002/07/owl#Class
rdf-schema#range
https://w3id.org/def/predibionto#has_drug_113247
owl#annotatedSource
t218052
has_treatment
http://purl.obolibrary.org/obo/DOID_8567
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t2991577